J Korean Med Sci.  2010 Oct;25(10):1438-1442. 10.3346/jkms.2010.25.10.1438.

Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma

• Chen L
• Yuan D
• Wang GL
• Wang Y
• Wu YY
• Zhu J

• KMID: 2157846
• DOI: http://doi.org/10.3346/jkms.2010.25.10.1438

Abstract

The aim of this study was to investigate the expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma (HCC) and their clinicopathological significance. The expression of Tspan-1, Jab1 and p27 was detected in HCC tissues, the tissues around cancer (76 cases), and the normal tissues around the liver hemangiomas (10 cases). The overexpression of Tspan-1 and Jab1 was found in HCC tissues, positively correlated with clinical stage and negatively correlated with survival rate. The expression of p27 was found inversely linked to which of Tspan-1 and Jab1. In conclusion, the expression of Tspan-1, Jab1 and p27 is significantly associated with development of HCC. Overexpression of Tspan-1 and Jab1 suggests poor prognosis but overexpression of p27 may expect good prognosis for patients with HCC.

Keyword

Carcinoma, Hepatocellular; Tspan-1; Jab1; p27; Prognosis

MeSH Terms

Adult
Aged
Carcinoma, Hepatocellular/metabolism/mortality/*pathology
Cyclin-Dependent Kinase Inhibitor p27/*metabolism
Female
Humans
Intracellular Signaling Peptides and Proteins/*metabolism
Liver Neoplasms/metabolism/mortality/*pathology
Male
Membrane Proteins/*metabolism
Middle Aged
Peptide Hydrolases/*metabolism
Prognosis
Survival Rate

Figure

• 

  Fig. 1 Immunostaining of Tspan-1, Jab1 and p27 in HCC. (A) Tspan-1 expression, indicated by yellowish granules, varies from cytoplasm to membrane, or mixed. (B) Jab1 and (C) p27 expression, indicated by brownish yellow granules, are mainly in nuclear, but also can be found in cytoplasm. Magnification ×200.

• 

  Fig. 2 Kapalan-Meier survival curves of patients with HCC. (A) Overall survival rate is significantly lower in patients with Tspan-1 overexpression. (B) Overall survival rate is significantly lower in patients with Jab1 overexpression. (C) Overall survival rate is significantly higher in patients with p27 overexpression.

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