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Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing

Park BM, Roh JI, Lee J, Lee HW

Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers....
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p16(INK4a) Expression in Porokeratosis

Uryu M, Furue M

No abstract available.
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Human Papillomavirus Genotyping and p16INK4a Expression in Cervical Lesions: A Combined Test to Avoid Cervical Cancer Progression

Zouheir Y, Fechtali T, Elgnaoui N

Cervical cancer is a major public health problem in Morocco. The cervical cancer has a long precancerous period that provides an opportunity for the screening and treatment. Improving screening tests...
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p16 Hypermethylation and KRAS Mutation Are Independent Predictors of Cetuximab Plus FOLFIRI Chemotherapy in Patients with Metastatic Colorectal Cancer

Kim SH, Park KH, Shin SJ, Lee KY, Kim TI, Kim NK, Rha SY, Roh JK, Ahn JB

PURPOSE: Hypermethylation of the CpG island of p16(INK4a) occurs in a significant proportion of colorectal cancer (CRC). We aimed to investigate its predictive role in CRC patients treated with 5-fluorouracil,...
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Clinical Relevance of High-Resolution Single Nucleotide Polymorphism Array in Patients with Relapsed Acute Lymphoblastic Leukemia with Normal Karyotype: A Report of Three Cases

Park SH, Lee SH, Kim SY, Lee SM, Yi J, Kim IS, Kim HH, Chang CL, Lee EY

We report three patients with normal karyotype (NK) ALL, who showed genetic aberrations as determined by high-resolution single nucleotide polymorphism array (SNP-A) analysis at both diagnosis and relapse. We evaluated...
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Distribution of Human Papillomavirus 52 and 58 Genotypes, and Their Expression of p16 and p53 in Cervical Neoplasia

Kim TE, Kim HW, Lee KE

  • KMID: 1875754
  • Korean J Pathol.
  • 2014 Feb;48(1):24-29.
BACKGROUND: This study investigates the prevalence of human papillomavirus (HPV) 52 and 58 genotypes among women residing in Busan, and the expression of p16 and p53 proteins in cervical neoplasia...
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Cervical preneoplasia biomarkers: a conundrum for the community based gynecologic surgical pathologist

van Bogaert LJ

The integration of high-risk (HR) human papillomavirus (HPV) in the cell genome is an essential step in the oncogenic pathway of lower ano-genital HPV-related squamous preinvasive and invasive lesions. The...
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Human Papillomavirus Prevalence and Cell Cycle Related Protein Expression in Tonsillar Squamous Cell Carcinomas of Korean Patients with Clinicopathologic Analysis

Lee M, Kim SB, Lee SW, Roh JL, Choi SH, Nam SY, Kim SY, Cho KJ

  • KMID: 2277459
  • Korean J Pathol.
  • 2013 Apr;47(2):148-157.
BACKGROUND: Human papillomavirus (HPV)-related tonsillar squamous cell carcinoma (TSCC) has recently been characterized as a distinct subset with a favorable prognosis. The prevalence and clinicopathologic significance of HPV-related TSCC in...
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Prevalence of p16 Methylation and Prognostic Factors in Plasma Cell Myeloma at a Single Institution in Korea

Kim H, Jekarl DW, Kim M, Kim Y, Lim J, Han K, Min CK

BACKGROUND: The primary purpose of this study was to investigate the prevalence and characteristics of p16 methylation and determine the prognostic implications of the clinical data, hematologic data, and p16...
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Effect of Helicobacter pylori Infection on p16, p53, CEA, EGFR Expression in Gastric Neoplasia

Won CS, Cho MY, Kim HS, Suk KT, Kim JW, Park HJ, Jeon HK, Baik SK, Kwon SO

BACKGROUND/AIMS: Gastric cancer is one of the most widespread cancers and the second leading cause of cancer-related death worldwide. Although Helicobacter pylori (H. pylori) has been classified as a type...
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Overexpressions of Cyclin B1, cdc2, p16 and p53 in Human Breast Cancer: The Clinicopathologic Correlations and Prognostic Implications

Chae SW, Sohn JH, Kim DH, Choi YJ, Park YL, Kim K, Cho YH, Pyo JS, Kim JH

PURPOSE: The molecular mechanisms that are responsible for the initiation and progression of breast cancers are largely unknown. This study was to analyze the cyclin B1, cdc2, p53 and p16...
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Blastoid Mantle Cell Lymphoma: A Case Report

Shin JW, Yang JH, Lee SY, Lee JS, Park YL, Cho MK, Cho HD

  • KMID: 2301848
  • Korean J Dermatol.
  • 2010 Aug;48(8):684-688.
Mantle cell lymphoma (MCL) is a low-grade malignant lymphoma derived from a subset of B-cells localized in the mantle zone of the lymphoid follicle. MCL commonly involves extranodal sites, usually...
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The Keratin-14 Expression in Actinic Keratosis and Squamous Cell Carcinoma: Is This a Prognostic Factor for Tumor Progression?

Choi KH, Kim GM, Kim SY

  • KMID: 2165966
  • Cancer Res Treat.
  • 2010 Jun;42(2):107-114.
PURPOSE: Actinic keratosis (AK) is an incipient form of cutaneous squamous cell carcinoma (SCC). We determined if the pattern of expression of keratin-14 (K14) is a factor for tumor progression...
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p16(INK4A) promoter hypermethylation and expression of p16(INK4A), cyclin D1, and Rb in papillary thyroid carcinoma

Kim YJ, Kim HS, Ha YJ, Lee HY, Park KG, Kim MK, Kwon SY

  • KMID: 2259183
  • Korean J Med.
  • 2010 Mar;78(3):333-340.
BACKGROUND/AIMS: Dysregulation of the cell cycle is believed to be important in human neoplasia. p16(INK4A), a regulator of the retinoblastoma protein, is inactivated by several mechanisms, including hypermethylation of the...
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Evaluation of the HPV ISH Assay in Cervical Cancer

Lee JU, Shin JH, Kim JO, Choi YJ, Lee KY, Park JS, Lee WC, Lee A

  • KMID: 2277560
  • Korean J Pathol.
  • 2010 Oct;44(5):513-520.
BACKGROUND: Human papillomavirus (HPV) infection can be detected by in situ hybridization (ISH), in which a punctate signal pattern indicates integrated HPV DNA and a diffuse pattern denotes the presence...
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Expression of pRb, p53, p16 and Cyclin D1 and Their Clinical Implications in Urothelial Carcinoma

Lee K, Jung ES, Choi YJ, Lee KY, Lee A

The aim of this study was to assess immunohistochemical expression of p53, pRb, p16, and cyclin D1, alone or in combination, as prognostic indicators and to investigate their correlation with...
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The Overexpression of Histone Deacetylase 1 and Its Relationship with p16INK4a Gene Hypermethylation in Pulmonary Squamous Cell Carcinoma and Adenocarcinoma

Park JH, Hong YS, Choi PJ, Kim NY, Lee KE, Roh MS

  • KMID: 2073788
  • Korean J Pathol.
  • 2009 Apr;43(2):107-112.
BACKGROUND: DNA methylation and histone modification are dynamically linked in the epigenetic control of gene silencing and they play an important role in tumorigenesis. METHODS: To evaluate the role of histone...
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Clinical Utility of Fluorescence in-situ Hybridization Profile Test in Detecting Genetic Aberrations in Acute Leukemia

Kim SR, Kim HJ, Kim SH

BACKGROUND: Cytogenetic abnormalities are one of the most reliable prognostic factors in acute leukemia. Combination of conventional chromosome analysis (CCA) and FISH provides higher sensitivity in detecting these genetic abnormalities,...
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Expression of the p16(INK4a) and Ki-67 in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection

Nam EJ, Kim JW, Hong JW, Jang HS, Lee SY, Jang SY, Lee DW, Kim SW, Kim JH, Kim YT, Kim S, Kim JW

OBJECTIVE: The purposes of this study were to evaluate the expression of p16(INK4a) (referred as to p16) and Ki-67 in cervical intraepithelial neoplasia (CIN), and the correlation between high-risk human...
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Cyclin D1 Overexpression, p16 Loss, and pRb Inactivation Play a Key Role in Pulmonary Carcinogenesis and have a Prognostic Implication for the Long-term Survival in Non-small Cell Lung Carcinoma Patients

Myong NH

  • KMID: 2166001
  • Cancer Res Treat.
  • 2008 Jun;40(2):45-52.
PURPOSE: We investigated the immunoexpressions of cyclin D1, cyclin-dependent kinase inhibitor p16 and phosphorylated retinoblastoma (p-pRb) proteins in non- small cell lung carcinoma (NSCLC) to demonstrate their key roles in...
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