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Organoid as a culture system for viral vaccine strains

Hong KJ, Seo SH

Organoid is an in vitro multicellular form mimicking in vivo organ. Its similarity to human organ including cellular organization, molecular expression patterns, as well as genetic signatures enables to study...
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Strategies to maintain Korea's animal rabies non-occurrence status

Yang DK, Kim HH, Cho IS

Endemic animal rabies causes >99% of all human rabies cases; elimination of animal rabies reduces the rate of human infections. The most recent animal rabies cases in the Gangwon and...
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Recent progress in microneme-based vaccines development against Toxoplasma gondii

Foroutan M, Zaki L, Ghaffarifar F

Toxoplasmosis is a cosmopolitan zoonotic disease, which infect several warm-blooded mammals. More than one-third of the human population are seropositive worldwide. Due to the high seroprevalence of Toxoplasma gondii infection...
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Genetic identification and serological evaluation of commercial inactivated foot-and-mouth disease virus vaccine in pigs

Je SH, Kwon T, Yoo SJ, Lee DU, Seo SW, Byun JJ, Shin JY, Lyoo YS

Vaccination is considered a frequently used tool to prevent and control foot-and-mouth disease (FMD). However, the effectiveness of conventional FMD virus (FMDV) vaccines in pigs has been controversial because the...
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Evaluation of EZplex MTBC/NTM Real-Time PCR kit: diagnostic accuracy and efficacy in vaccination

Lee S, Hwang KA, Ahn JH, Nam JH

PURPOSE: Tuberculosis (TB) is mainly caused by Mycobacterium tuberculosis, which is a pathogenic mycobacterial species grouped under Mycobacterium tuberculosis complex (MTBC) with four other pathogenic mycobacterial species. The mycobacteria not...
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Development of dual reporter imaging system for Francisella tularensis to monitor the spatio-temporal pathogenesis and vaccine efficacy

Kim YH, Park PG, Seo SH, Hong KJ, Youn H

PURPOSE: Study on the pathogen and the pathogen-related disease require the information at both cellular and organism level. However, lack of appropriate high-quality antibodies and the difference between the experimental...
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Immunogenicity of a bivalent killed thimerosal-free oral cholera vaccine, Euvichol, in an animal model

Lee EY, Lee S, Rho S, Kim JO, Choi SK, Lee YJ, Park JY, Song M, Yang JS

PURPOSE: An oral cholera vaccine (OCV), Euvichol, with thimerosal (TM) as preservative, was prequalified by the World Health Organization (WHO) in 2015. In recent years, public health services and regulatory...
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Purification and characterization of monoclonal IgG antibodies recognizing Ebola virus glycoprotein

Han BS, Jang HY, Racine T, Qiu X, Sin JI

PURPOSE: The goal of this study was to purify and characterize Ebola virus glycoprotein (GP)-specific IgG antibodies from hybridoma clones. MATERIALS AND METHODS: For hybridoma production, mice were injected by intramuscular-electroporation...
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