Clin Exp Vaccine Res.  2018 Jul;7(2):145-148. 10.7774/cevr.2018.7.2.145.

Organoid as a culture system for viral vaccine strains

• Hong KJ
• Seo SH

• KMID: 2418093
• DOI: http://doi.org/10.7774/cevr.2018.7.2.145

Abstract

Organoid is an in vitro multicellular form mimicking in vivo organ. Its similarity to human organ including cellular organization, molecular expression patterns, as well as genetic signatures enables to study the characteristics of infectious agents and host-pathogen interaction. For the features of organoid, this system also can be potentially used to cultivate currently uncultivable viruses of vaccine candidates. This paper will briefly describe problems in the current culture system for virus production and the possibility of organoid as culture system for viral vaccine and their current limitations that should be solved to meet the goal.

Keyword

Organoids; Viral vaccines; Virus cultivation; Viral gene mutation

MeSH Terms

Host-Pathogen Interactions
Humans
In Vitro Techniques
Organoids*
Viral Vaccines
Virus Cultivation
Viral Vaccines

Figure

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  Fig. 1 Sources, types, and application of currently established organoids.

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