- Troglitazone and tumor inhibition: an evolving concept in the management of systemic malignancies
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Kapoor S
- KMID: 2316723
- Radiat Oncol J.
- 2012 Dec;30(4):226-227.
No abstract available. -
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- Effects of Gamma-Tocopherol (GT) Supplementation on Vitamin E Concentration in Cigarette Smoke (CS) Exposed Mice
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Lim Y
- KMID: 2261309
- Korean J Nutr.
- 2008 Mar;41(2):135-140.
Cigarette smoke (CS) induces oxidative and nitrosative stress to the respiratory tract (RT) via both oxidants contained in CS and by CS-induced activation of RT inflammatory-immune pro-oxidant processes. CS exposure... -
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- Over-expression of PTEN Involved in Troglitazone-induced Apoptosis in Human Osteosarcoma Cells
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Yoon SJ, Zhou L, Kim JR
- KMID: 2137040
- J Korean Bone Joint Tumor Soc.
- 2011 Jun;17(1):23-29.
- doi: 10.5292/jkbjts.2011.17.1.23
PURPOSE: We investigated the effects of phosphatase and tensin homologue deleted on chromosome 10 gene phosphatase and tensin homologue deleted on chromosome 10 gene (PTEN) expression on the cell proliferation... -
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- Effects of Co-treatment with Dexamethasone and Troglitazone on Transcription and Secretion of IL-8 in the A549 Airway Epithelial Cells
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- KMID: 2234553
- Korean J Asthma Allergy Clin Immunol.
- 2008 Dec;28(4):292-297.
BACKGROUND: Glucocorticoid is a widely used anti-inflammatory agent in a variety of diseases. Recently, peroxisome proliferator activated receptor gamma (PPAR gamma) ligand has been shown to exert a potential anti-inflammatory... -
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- The Effect of Troglitazone on Thermal Sensitivity in Uterine Cervix Cancer Cells
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Lee JH, Kim WD, Yu JR, Park WY
- KMID: 1460157
- J Korean Soc Ther Radiol Oncol.
- 2010 Jun;28(2):91-98.
- doi: 10.3857/jkstro.2010.28.2.91
PURPOSE: Troglitazone (TRO), a PPAR-gamma agonist, can reduce heat shock protein (HSP) 70 and increase the antioxidant enzymes, such as superoxide dismutase (SOD) and catalase, which might affect thermal sensitivity.... -
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- Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy
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Park H, Ko SH, Lee JM, Park JH, Choi YH
- KMID: 2427170
- Yonsei Med J.
- 2016 Nov;57(6):1494-1499.
- doi: 10.3349/ymj.2016.57.6.1494
PURPOSE: The aim of this study was to investigate whether the peroxisomal proliferator-activated receptor gamma (PPARγ) ligand troglitazone in combination with photodynamic therapy (PDT) enhances the apoptotic response of DLD-1... -
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- Optimized mixture of hops rho iso-alpha acids-rich extract and acacia proanthocyanidins-rich extract reduces insulin resistance in 3T3-L1 adipocytes and improves glucose and insulin control in db/db mice
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Tripp ML, Darland G, Konda VR, Pacioretty LM, Chang JL, Bland JS, Babish JG
- KMID: 2313622
- Nutr Res Pract.
- 2012 Oct;6(5):405-413.
Rho iso-alpha acids-rich extract (RIAA) from Humulus lupulus (hops) and proanthocyanidins-rich extracts (PAC) from Acacia nilotica exert anti-inflammatory and anti-diabetic activity in vitro and in vivo. We hypothesized that a... -
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- Effect of troglitazone on radiation sensitivity in cervix cancer cells
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An Z, Liu X, Song H, Choi C, Kim WD, Yu JR, Park WY
- KMID: 1494298
- Radiat Oncol J.
- 2012 Jun;30(2):78-87.
- doi: 10.3857/roj.2012.30.2.78
PURPOSE: Troglitazone (TRO) is a peroxisome proliferator-activated receptor gamma (PPARgamma) agonist. TRO has antiproliferative activity on many kinds of cancer cells via G1 arrest. TRO also increases Cu2+/Zn2+-superoxide dismutase (CuZnSOD)... -
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- DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappa B Activity in LPS-treated Human Umbilical Vein Endothelial Cells
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Lee SA, Kim HJ, Chang KC, Baek JC, Park JK, Shin JK, Choi WJ, Lee JH, Paik WY
- KMID: 2071685
- Korean J Physiol Pharmacol.
- 2009 Aug;13(4):301-307.
- doi: 10.4196/kjpp.2009.13.4.301
Inflammatory processes of vascular endothelial cells play a key role in the development ofatherosclerosis. We determined the anti-inflammatory effects and mechanisms of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on... -
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- The Antiproliferative and Redifferentiative Effects of Na-4-Phenylbutyrate in Human Thyroid Cancer Cell Lines
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Choi YJ, Park JW, Jang LC, Choi JW, Clark OH
- KMID: 1476278
- J Korean Surg Soc.
- 2008 Sep;75(3):162-170.
PURPOSE: Sodium-4-phenylbutyrate (Na-4-PB) is an analogue of phenylacetate, which is a well-known redifferentiating agent. In vitro and in vivo studies on this agent have been done and the clinical relevance... -
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- Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus
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Lee YM, Gweon OC, Seo YJ, Im J, Kang MJ, Kim MJ, Kim JI
- KMID: 2313392
- Nutr Res Pract.
- 2009 Jun;3(2):156-161.
Hyperglycemia in the diabetic state increases oxidative stress and antioxidant therapy can be strongly correlated with decreased risks for diabetic complications. The purpose of this study is to determine antioxidant... -
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- A Carbohydrate Fraction, AIP1, from Artemisia Iwayomogi Reduces the Action Potential Duration by Activation of Rapidly Activating Delayed Rectifier K+ Channels in Rabbit Ventricular Myocytes
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Park WS, Son YK, Ko EA, Choi SW, Kim N, Choi TH, Youn HJ, Jo SH, Hong DH, Han J
- KMID: 2285391
- Korean J Physiol Pharmacol.
- 2010 Jun;14(3):119-125.
- doi: 10.4196/kjpp.2010.14.3.119
We investigated the effects of a hot-water extract of Artemisia iwayomogi, a plant belonging to family Compositae, on cardiac ventricular delayed rectifier K+ current (I(K)) using the patch clamp technique.... -
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- Peroxisome proliferator-activated receptor gamma ligands exert antineoplastic effects in hepatocellular carcinoma cells
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Chae MJ, Shim J, Kim BH, Hwangbo Y, Lee YJ, Ha SH, Jang JY, Dong SH, Kim HJ, Chang YW, Chang R
- KMID: 2258779
- Korean J Med.
- 2008 Sep;75(3):288-299.
BACKGROUND/AIMS: Thiazolidinediones, which are synthetic insulin sensitizers, are known activators of peroxisome proliferator-activated receptor gamma (PPARgamma). PPARgamma ligands, including endogenous 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2), are thought to elicit antineoplastic effects in... -
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- The Effects of Combined Treatment with an HMG-CoA Reductase Inhibitor and PPARgamma Agonist on the Activation of Rat Pancreatic Stellate Cells
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Lee BJ, Lee HS, Kim CD, Jung SW, Seo YS, Kim YS, Jeen YT, Chun HJ, Um SH, Lee SW, Choi JH, Ryu HS
- KMID: 2284274
- Gut Liver.
- 2012 Apr;6(2):262-269.
BACKGROUND/AIMS: Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) and peroxisome proliferator-activated receptor gamma (PPARgamma) ligands can modulate cellular differentiation, proliferation, and apoptosis through various pathways. It has been shown that HMG-CoA... -
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- EFFECTS OF HYDROQUINONE ON NEOPLASTIC TRANSFORMATION OF HUMAN EPITHELIAL CELLS IN CULTURE
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Sohn JH, Kim CS
- KMID: 2186578
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2010 May;32(3):218-228.
Components of dental resin-based restorative materials are reported to leach from the filling materials even after polymerization. Hydroquinone (HQ) is one of the major monomers used in the dental resin... -
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- Anti-oxidative neuroprotection by estrogens in mouse cortical cultures
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Bae YH, Hwang JY, Kim YH, Koh JY
- KMID: 1128633
- J Korean Med Sci.
- 2000 Jun;15(3):327-336.
- doi: 10.3346/jkms.2000.15.3.327
Estrogen replacement therapy in postmenopausal women may reduce the risk of Alzheimer's disease, possibly by ameliorating neuronal degeneration. In the present study, we examined the neuroprotective spectrum of estrogen against... -
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- Duration and Magnitude of Extracellular Signal-Regulated Protein Kinase Phosphorylation Determine Adipogenesis or Osteogenesis in Human Bone Marrow-Derived Stem Cells
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Jung HS, Kim YH, Lee JW
- KMID: 1106452
- Yonsei Med J.
- 2011 Jan;52(1):165-172.
- doi: 10.3349/ymj.2011.52.1.165
PURPOSE: Imbalances between osteogenic and adipogenic differentiation leads to diseases such as osteoporosis. The aim of our study was to demonstrate the differences in extracellular signal-regulated kinase (ERK) phosphorylation during... -
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- Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-gamma
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Lee KJ, Kim HA, Kim PH, Lee HS, Ma KR, Park JH, Kim DJ, Hahn JH
- KMID: 1103320
- Exp Mol Med.
- 2004 Dec;36(6):534-544.
During chronic inflammatory response, mono- cytes/macrophages produce 92-kDa matrix metalloproteinase-9 (MMP-9), which may contribute to their extravasation, migration and tissue remodeling. Activation of peroxisome proliferator- activated factor receptor-gamma (PPAR-gamma) has... -
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- 15-Deoxy-delta12,14-PGJ2inhibits IL-6-induced Stat3 phosphorylation in lymphocytes
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Kim HJ, Rho YH, Choi SJ, Lee YH, Cheon HJ, Um JW, Sohn J, Song GG, Ji JD
- KMID: 1056229
- Exp Mol Med.
- 2005 Jun;37(3):179-185.
15-deoxy-delta12,14-PGJ2(15d-PGJ2) is a natural ligand that activates the peroxisome proliferators-activated receptor (PPAR) gamma, a member of nuclear receptor family implicated in regulation of lipid metabolism and adipocyte differentiation. Recent studies... -
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- CD36 signaling inhibits the translation of heat shock protein 70 induced by oxidized low density lipoprotein through activation of peroxisome proliferators-activated receptor gamma
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Lee KJ, Ha ES, Kim MK, Lee SH, Suh JS, Lee SH, Park KH, Park JH, Kim DJ, Kang D, Kim BC, Jeoung D, Kim YK, Kim HD, Hahn JH
- KMID: 1072946
- Exp Mol Med.
- 2008 Dec;40(6):658-668.
- doi: 10.3858/emm.2008.40.6.658
Oxidized LDL (OxLDL), a causal factor in atherosclerosis, induces the expression of heat shock proteins (Hsp) in a variety of cells. In this study, we investigated the role of CD36,... -
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