- Pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity
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Chung WB, Youn HJ
- KMID: 2327736
- Korean J Intern Med.
- 2016 Jul;31(4):625-633.
- doi: 10.3904/kjim.2016.017
Cardiotoxicity is a well-known complication following treatment with anthracyclines. However, they are still widely used in chemotherapy for breast cancer, lymphoma, leukemia, and sarcoma, among others. Patient clinical characteristics, such... -
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- Long-term cardiac composite risk following adjuvant treatment in breast cancer patients
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Choi HB, Yun S, Cho SW, Lee MH, Lee J, Park S
- KMID: 2432607
- Korean J Clin Oncol.
- 2018 Dec;14(2):102-107.
- doi: 10.14216/kjco.18018
PURPOSE: Cardiotoxicity is a serious late complication of breast cancer treatment. Individual treatment risk of specific drugs has been investigated. However, studies on the evaluation of the composite risk of... -
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- Comparision of doxorubicin-induced cardiotoxicity in the ICR mice of different sources
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Kim SH, Kim KJ, Kim JH, Kwak JH, Song H, Cho JY, Hwang DY, Kim KS, Jung YS
- KMID: 2407431
- Lab Anim Res.
- 2017 Jun;33(2):165-170.
- doi: 10.5625/lar.2017.33.2.165
Doxorubicin is a widely used chemotherapeutic agents and is now part of standard therapeutic regimens for a variety of cancers (eg, hematopoietic malignancies and advanced solid tumors of the breast,... -
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- Correlation of UGT2B7 Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy
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Li H, Hu B, Guo Z, Jiang X, Su X, Zhang X
- KMID: 2428275
- Yonsei Med J.
- 2019 Jan;60(1):30-37.
- doi: 10.3349/ymj.2019.60.1.30
PURPOSE: The present study aimed to investigate correlations between uridine glucuronosyltransferase 2B7 (UGT2B7) -161 single nucleotide polymorphism C to T (C>T) and the occurrence of cardiotoxicity in Chinese breast cancer... -
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- Loss of endogenous estrogen increases cardiac toxicity by doxorubicin
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Lee YH, Lee SR, Kwon SW, Lee SY, Park BK, Hong EJ
- KMID: 2405359
- J Biomed Transl Res.
- 2017 Dec;18(4):146-150.
- doi: 10.12729/jbtr.2017.18.4.146
Breast cancer is of enormous concern worldwide and linked with age, sex, hormonal factors, and family history. The treatment of early breast cancer includes treating the disease locally with surgery,... -
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- A Fatal Case of Colchicine Poisoning
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Ko SH, Lee GW
- KMID: 2386866
- J Korean Soc Clin Toxicol.
- 2017 Jun;15(1):51-55.
- doi: 10.22537/jksct.2017.15.1.51
Colchicine is a drug that has long been used to treat a variety of illnesses; however, it reportedly has adverse effects at apparent toxic doses as well as at lower... -
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- Fatal Peripartum Cardiomyopathy after Bupivacaine Local Injection in Elective Cesarean Section: A Case Report
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Park JY, Kang HR, Kim JH, Kim HW, Kim SM, Chang YJ, Choe KH, Lee KM, An JY
- KMID: 2164253
- J Korean Soc Emerg Med.
- 2016 Apr;27(2):214-218.
- doi: 10.0000/jksem.2016.27.2.214
Bupivacaine is frequently used for pain control and local anesthesia. However, it is associated with certain acute and fatal side effects, although rare, including cardiac and central nervous system toxicities.... -
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- A Case of Aconite Poisoning Successfully Recovered after Intravenous Fat Emulsion Therapy
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Shin HJ, Lim H
- KMID: 2328241
- J Korean Soc Clin Toxicol.
- 2016 Jun;14(1):60-65.
Aconitum is a genus of various species of flowering plants that belongs to the Family Ranunculaceae. Most Aconitum sp. have extremely toxic alkaloid substances such as aconitine, mesaconitine and hypaconitine.... -
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- Introduction to in silico model for proarrhythmic risk assessment under the CiPA initiative
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Park JS, Jeon JY, Yang JH, Kim MG
- KMID: 2442241
- Transl Clin Pharmacol.
- 2019 Mar;27(1):12-18.
- doi: 10.12793/tcp.2019.27.1.12
In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human... -
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- Clinical Characteristics and Treatment of Immune-Related Adverse Events of Immune Checkpoint Inhibitors
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Choi J, Lee SY
- KMID: 2471049
- Immune Netw.
- 2020 Feb;20(1):e9.
- doi: 10.4110/in.2020.20.e9
Immune checkpoint inhibitors (ICIs) have been changing the paradigm of cancer treatment. However, immune-related adverse effects (irAEs) have also increased with the exponential increase in the use of ICIs. ICIs... -
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- Diagnosis, Treatment, and Prevention of Cardiovascular Toxicity Related to Anti-Cancer Treatment in Clinical Practice: An Opinion Paper from the Working Group on Cardio-Oncology of the Korean Society of Echocardiography
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Kim H, Chung WB, Cho KI, Kim BJ, Seo JS, Park SM, Kim HJ, Lee JH, Kim EK, Youn HJ
- KMID: 2407677
- J Cardiovasc Ultrasound.
- 2018 Mar;26(1):1-25.
- doi: 10.4250/jcu.2018.26.1.1
Cardiovascular (CV) toxicity associated with anti-cancer treatment is commonly encountered and raises critical problems that often result in serious morbidity or mortality. Most cardiac toxicities are related to the cumulative... -
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- A Case of Successfully Treated Severe Heart Failure due to Cyclophosphamide Induced Cardiomyopathy
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Park JM, Hahn SM, Han JW, Lyu CJ
- KMID: 2435428
- Clin Pediatr Hematol Oncol.
- 2018 Apr;25(1):71-75.
- doi: 10.15264/cpho.2018.25.1.71
Cyclophosphamide-induced cardiotoxicity is an uncommon complication especially in patients who have never undergone mediastinal irradiation or cardiotoxic chemotherapy and do not have underlying cardiac diseases. Here, we describe the case... -
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- Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart
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Okada JI, Washio T, Sugiura S, Hisada T
- KMID: 2455805
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):295-303.
- doi: 10.4196/kjpp.2019.23.5.295
A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and... -
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- Early Decline in Left Ventricular Ejection Fraction Can Predict Trastuzumab-Related Cardiotoxicity in Patients with Breast Cancer: A Study Using 13 Years of Registry Data
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Kim EK, Cho J, Kim JY, Chang SA, Park SJ, Choi JO, Lee SC, Ahn JS, Park SW, Im YH, Jeon ES, Park YH
- KMID: 2464418
- Cancer Res Treat.
- 2019 Apr;51(2):727-736.
- doi: 10.4143/crt.2018.262
PURPOSE: While concerns regarding trastuzumab-related cardiac dysfunction (TRCD) in patients with breast cancer are increasing, there is a lack of evidence supporting the current recommendations for TRCD monitoring. We aimed... -
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- Ginsenoside Rb1 Inhibits Doxorubicin-Triggered H9C2 Cell Apoptosis via Aryl Hydrocarbon Receptor
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Zhang Y, Wang Y, Ma Z, Liang Q, Tang X, Tan H, Xiao C, Gao Y
- KMID: 2375041
- Biomol Ther.
- 2017 Mar;25(2):202-212.
- doi: 10.4062/biomolther.2016.066
Doxorubicin (DOX) is a highly effective chemotherapeutic agent; however, the dose-dependent cardiotoxicity associated with DOX significantly limits its clinical application. In the present study, we investigated whether Rb1 could prevent... -
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- Which Patients with Left Breast Cancer Should be Candidates for Heart-Sparing Radiotherapy?
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Cho WK, Park W, Choi DH, Cha H, Nam SJ, Kim SW, Lee JE, Yu J, Im YH, Ahn JS, Park YH, Kim JY
- KMID: 2413940
- J Breast Cancer.
- 2018 Jun;21(2):206-212.
- doi: 10.4048/jbc.2018.21.2.206
PURPOSE: This study aimed to identify risk factors that have significant interaction with radiation exposure to the heart, and thus to determine candidates for heart-sparing radiotherapy (RT) among women with... -
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- Chemotherapy-Induced Left Ventricular Dysfunction in Patients with Breast Cancer
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Yoon HJ, Kim KH, Kim JY, Park HJ, Cho JY, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC
- KMID: 2362926
- J Breast Cancer.
- 2016 Dec;19(4):402-409.
- doi: 10.4048/jbc.2016.19.4.402
PURPOSE: As the numbers of cancer cases and survivors increase, the incidence and natural history of chemotherapy-induced cardiotoxicities in patients with breast cancer may also be expected to change. The... -
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- Antitumor profiles and cardiac electrophysiological effects of aurora kinase inhibitor ZM447439
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Lee HA, Kwon M, Kim HA, Kim KS
- KMID: 2455815
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):393-402.
- doi: 10.4196/kjpp.2019.23.5.393
Aurora kinases inhibitors, including ZM447439 (ZM), which suppress cell division, have attracted a great deal of attention as potential novel anti-cancer drugs. Several recent studies have confirmed the anti-cancer effects... -
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- Cardioprotective Effect of Dexrazoxane in Patients with HER2-Positive Breast Cancer Who Receive Anthracycline Based Adjuvant Chemotherapy Followed by Trastuzumab
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Kim IH, Lee JE, Youn HJ, Song BJ, Chae BJ
- KMID: 2379402
- J Breast Cancer.
- 2017 Mar;20(1):82-90.
- doi: 10.4048/jbc.2017.20.1.82
PURPOSE: We intended to determine whether dexrazoxane (DZR) is cardioprotective during administration of adjuvant anthracycline-based chemotherapy followed by a 1-year trastuzumab treatment. METHODS: The medical records of 228 patients who underwent... -
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- The Relation between Acute Adriamycin induced Cardiomyopathy and Apoptosis in rat : Study using 15 MHz High Frequency Transducer
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Choi YS, Park CS, Cho EJ, Jung HO, Jeon HK, Kang JH, Lee JH, Youn HJ, Chae JS, Kim JH, Cho KB, Hong SJ
- KMID: 2408609
- J Korean Soc Echocardiogr.
- 2002 Dec;10(2):35-43.
BACKGROUND: Anthracyclines, such as daunorubicin or doxorubicin that are one of the most widely used as chemotherapeutic agents in oncology clinics have the limitation of its usage because of severe... -
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