- How Can We Treat Cancer Disease Not Cancer Cells?
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Kim KW, Lee SJ, Kim WY, Seo JH, Lee HY
- KMID: 2367497
- Cancer Res Treat.
- 2017 Jan;49(1):1-9.
- doi: 10.4143/crt.2016.606
Since molecular biology studies began, researches in biological science have centered on proteins and genes at molecular level of a single cell. Cancer research has also focused on various functions... -
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- Analysis of the Clinicopathological Characteristics of Gastric Cancer in Extremely Old Patients
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Sohn IW, Jung DH, Kim JH, Chung HS, Park JC, Shin SK, Lee SK, Lee YC
- KMID: 2367518
- Cancer Res Treat.
- 2017 Jan;49(1):204-212.
- doi: 10.4143/crt.2016.163
PURPOSE: Gastric cancer is the third-leading cause of cancer-related death in Korea. As the Korean population is ageing, the number of extremely old patients with this disease is increasing. This... -
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- Risk Factors for Thyroid Cancer: A Hospital-Based Case-Control Study in Korean Adults
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Myung SK, Lee CW, Lee J, Kim J, Kim HS
- KMID: 2367505
- Cancer Res Treat.
- 2017 Jan;49(1):70-78.
- doi: 10.4143/crt.2015.310
PURPOSE: Although the incidence of thyroid cancer in Korea has rapidly increased over the past decade, few studies have investigated its risk factors. This study examined the risk factors for... -
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- Use of a Combined Gene Expression Profile in Implementing a Drug Sensitivity Predictive Model for Breast Cancer
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Zhang X, Cha IH, Kim KY
- KMID: 2367509
- Cancer Res Treat.
- 2017 Jan;49(1):116-128.
- doi: 10.4143/crt.2016.085
PURPOSE: Chemotherapy targets all rapidly growing cells, not only cancer cells, and thus is often associated with unpleasant side effects. Therefore, examination of the chemosensitivity based on genotypes is needed... -
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- Association between Metformin Use and Survival in Nonmetastatic Rectal Cancer Treated with a Curative Resection: A Nationwide Population Study
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Ki YJ, Kim HJ, Kim MS, Park CM, Ko MJ, Seo YS, Moon SM, Choi JA
- KMID: 2367500
- Cancer Res Treat.
- 2017 Jan;49(1):29-36.
- doi: 10.4143/crt.2016.128
PURPOSE: Metformin is associated with an anticancer effect. However, the effects of metformin in rectal cancer are controversial. This study investigated the impact of metformin on the survival of patients... -
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- Gastric Carcinogenesis in the miR-222/221 Transgenic Mouse Model
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Choi B, Yu J, Han TS, Kim YK, Hur K, Kang BC, Kim WH, Kim DY, Lee HJ, Kim VN, Yang HK
- KMID: 2367512
- Cancer Res Treat.
- 2017 Jan;49(1):150-160.
- doi: 10.4143/crt.2015.462
PURPOSE: MicroRNAs (miRNAs) regulate various cellular functions, including development, cell proliferation, apoptosis, and tumorigenesis. Different signatures associated with various tissue types, diagnosis, progression, prognosis, staging, and treatment response have been... -
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- Irinotecan Monotherapy Versus Irinotecan-Based Combination as Second-Line Chemotherapy in Advanced Gastric Cancer: A Meta-Analysis
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Cho YH, Yoon SY, Kim SN
- KMID: 2367523
- Cancer Res Treat.
- 2017 Jan;49(1):255-262.
- doi: 10.4143/crt.2015.452
PURPOSE: A meta-analysis was conducted to examine the question of whether combination regimens are more effective than monotherapy as a second-line chemotherapy in advanced gastric cancer. MATERIALS AND METHODS: The MEDLINE... -
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- Human Herpesvirus 8–Unrelated Primary Effusion Lymphoma–Like Lymphoma in an Elderly Korean Patient with a Good Response to Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone
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Shin J, Lee JO, Choe JY, Bang SM, Lee JS
- KMID: 2367525
- Cancer Res Treat.
- 2017 Jan;49(1):274-278.
- doi: 10.4143/crt.2016.076
Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin’s lymphoma arising from a B-cell lineage characterized by the formation of malignant effusion in body cavities without evidence of a... -
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- Treatment of Pulmonary Tumor Embolism from Choriocarcinoma: Extracorporeal Membrane Oxygenation as a Bridge through Chemotherapy
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Chung JH, Yeo HJ, Cho HM, Jang JO, Ye BM, Yoon G, Shin DH, Kim D, Cho WH
- KMID: 2367526
- Cancer Res Treat.
- 2017 Jan;49(1):279-282.
- doi: 10.4143/crt.2016.125
A 22-year-old woman with a 1-month history of shortness of breath that was treated as a case of tuberculosis and pulmonary embolism was referred to the authors’ hospital. Because of... -
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- Use of a High-Throughput Genotyping Platform (OncoMap) for RAS Mutational Analysis to Predict Cetuximab Efficacy in Patients with Metastatic Colorectal Cancer
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Kim D, Hong YS, Kim JE, Kim KP, Lee JL, Chun SM, Kim J, Jang SJ, Kim TW
- KMID: 2367501
- Cancer Res Treat.
- 2017 Jan;49(1):37-43.
- doi: 10.4143/crt.2016.069
PURPOSE: Cetuximab demonstrates improved efficacy outcomes in patients with metastatic colorectal cancer (mCRC) harboring wild-type KRAS exon 2. Resistance to cetuximab is mediated by activating less frequent mutations in the... -
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- Clinical Practice Patterns of Radiotherapy in Patients with Hepatocellular Carcinoma: A Korean Radiation Oncology Group Study (KROG 14-07)
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Cha H, Park HC, Yu JI, Kim TH, Nam TK, Yoon SM, Yoon WS, Kim JW, Kim MS, Jang HS, Choi Y, Kim JH, Kay CS, Jung I, Seong J
- KMID: 2367504
- Cancer Res Treat.
- 2017 Jan;49(1):61-69.
- doi: 10.4143/crt.2016.097
PURPOSE: The aim of this study was to examine patterns of radiotherapy (RT) in Korean patients with hepatocellular carcinoma (HCC) according to the evolving guideline for HCC established by the... -
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- Optimal Adjuvant Treatment for Curatively Resected Thoracic Esophageal Squamous Cell Carcinoma: A Radiotherapy Perspective
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Kim KH, Chang JS, Cha JH, Lee IJ, Kim DJ, Cho BC, Park KR, Lee CG
- KMID: 2367514
- Cancer Res Treat.
- 2017 Jan;49(1):168-177.
- doi: 10.4143/crt.2016.142
PURPOSE: The purpose of this study was to evaluate the benefits of adjuvant treatment for curatively resected thoracic esophageal squamous cell carcinoma (ESCC) and determine the optimal adjuvant treatments. MATERIALS AND... -
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- Minimally Invasive Stereotactical Radio-ablation of Adrenal Metastases as an Alternative to Surgery
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Franzese C, Franceschini D, Cozzi L, D’Agostino G, Comito T, De Rose F, Navarria P, Mancosu P, Tomatis S, Fogliata A, Scorsetti
- KMID: 2367499
- Cancer Res Treat.
- 2017 Jan;49(1):20-28.
- doi: 10.4143/crt.2016.057
PURPOSE: The purpose of this study was to study the clinical outcome for patients with metastases of the adrenal gland treated with stereotactic body radiation therapy. MATERIALS AND METHODS: Forty-six patients... -
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- Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma
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Choi J, Kim SH, Koh YW, Choi EC, Lee CG, Keum KC
- KMID: 2367515
- Cancer Res Treat.
- 2017 Jan;49(1):178-184.
- doi: 10.4143/crt.2016.165
PURPOSE: The purpose of this study was to evaluate the clinical outcomes of patients treated with radiotherapy (RT) for a carcinoma of the external auditory canal (EAC) and middle ear. MATERIALS... -
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- Estimation of the Incidence of Hepatocellular Carcinoma and Cholangiocarcinoma in Songkhla, Thailand, 1989-2013, Using Multiple Imputation Method
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Yeesoonsang S, Bilheem S, McNeil E, Iamsirithaworn S, Jiraphongsa C, Sriplung H
- KMID: 2367503
- Cancer Res Treat.
- 2017 Jan;49(1):54-60.
- doi: 10.4143/crt.2016.045
PURPOSE: Histological specimens are not required for diagnosis of liver and bile duct (LBD) cancer, resulting in a high percentage of unknown histologies. We compared estimates of hepatocellular carcinoma (HCC)... -
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- Rare Incidence of ROS1 Rearrangement in Cholangiocarcinoma
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Lim SM, Yoo JE, Lim KH, Meng Tai D, Cho BC, Park YN
- KMID: 2367516
- Cancer Res Treat.
- 2017 Jan;49(1):185-192.
- doi: 10.4143/crt.2015.497
PURPOSE: The recent discovery and characterization of an oncogenic ROS1 gene rearrangement has raised significant interest because small molecule inhibitors are effective in these tumors. The aim of this study... -
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- Adjuvant Chemotherapy for Advanced Gastric Cancer in Elderly and Non-elderly Patients: Meta-Analysis of Randomized Controlled Trials
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Chang SH, Kim SN, Choi HJ, Park M, Kim RB, Go SI, Lee WS
- KMID: 2367524
- Cancer Res Treat.
- 2017 Jan;49(1):263-273.
- doi: 10.4143/crt.2016.054
PURPOSE: This study evaluated the benefits of adjuvant chemotherapy on elderly patients with advanced gastric cancer (AGC) using meta-analysis of well-designed randomized controlled clinical studies. MATERIALS AND METHODS: PubMed, Embase, and... -
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- Paired Primary and Metastatic Tumor Analysis of Somatic Mutations in Synchronous and Metachronous Colorectal Cancer
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Kim KP, Kim JE, Hong YS, Ahn SM, Chun SM, Hong SM, Jang SJ, Yu CS, Kim JC, Kim TW
- KMID: 2367513
- Cancer Res Treat.
- 2017 Jan;49(1):161-167.
- doi: 10.4143/crt.2015.490
PURPOSE: Although the mutation status of KRAS is highly concordant in primary and metastatic lesions, it has not been generalized to other major pathway genes. MATERIALS AND METHODS: In this study,... -
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- Reactive Oxygen Species Modulator 1 (Romo1) Predicts Poor Outcomes in Advanced Non-small Cell Lung Cancer Patients Treated with Platinum-Based Chemotherapy
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Lee SH, Choi SI, Lee JS, Kim CH, Jung WJ, Lee EJ, Min KH, Hur GY, Lee SH, Lee SY, Kim JH, Lee SY, Shin C, Shim JJ, Kang KH, In KH
- KMID: 2367511
- Cancer Res Treat.
- 2017 Jan;49(1):141-149.
- doi: 10.4143/crt.2016.133
PURPOSE: Reactive oxygen species modulator 1 (Romo1) is a key mediator of intracellular reactive oxygen species production. However, examination of the clinical usefulness of Romo1 in cancers has been limited.... -
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- A Phase II Study of Poziotinib in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma Who Have Acquired Resistance to EGFR–Tyrosine Kinase Inhibitors
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Han JY, Lee KH, Kim SW, Min YJ, Cho E, Lee Y, Lee SH, Kim HY, Lee GK, Nam BH, Han H, Jung J, Lee JS
- KMID: 2367498
- Cancer Res Treat.
- 2017 Jan;49(1):10-19.
- doi: 10.4143/crt.2016.058
PURPOSE: We examined the efficacy of poziotinib, a second-generation epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) in patients with lung adenocarcinoma with activating EGFR mutations, who developed acquired resistance... -
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