- Induction Mechanism of PD-L1 (Programmed Cell Death-ligand 1) in Sepsis
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Lee SM
- KMID: 2319096
- Tuberc Respir Dis.
- 2008 Oct;65(4):343-350.
PD-L1 is expressed in a variety of antigen-presenting cells and provides T cell tolerance via ligation with its receptor PD-1 and B7-1 on T cells. Stimulation with lipopolysaccharide (LPS) can... -
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- Occupational Cancer Update
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Ahn YS
- KMID: 2141473
- Korean J Occup Environ Med.
- 2011 Sep;23(3):235-252.
This article reviews newly available knowledge regarding occupational cancer based on an assessment of International Agency for Research on Cancer (IARC) Monograph program from 2006 to 2010. The IARC reviewed the... -
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- Blockade of ERK Phosphorylation in the Nucleus Accumbens Inhibits the Expression of Cocaine-induced Behavioral Sensitization in Rats
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Kim S, Shin JK, Yoon HS, Kim JH
- KMID: 2285426
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):389-395.
- doi: 10.4196/kjpp.2011.15.6.389
Repeated administration of psychostimulants such as cocaine leads to the development of behavioral sensitization. Extracellular signal-Regulated Kinase (ERK), an enzyme important for long-term neuronal plasticity, has been implicated in such... -
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- Effect of retinoic acid and delta-like 1 homologue (DLK1) on differentiation in neuroblastoma
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Kim Y
- KMID: 2313455
- Nutr Res Pract.
- 2010 Aug;4(4):276-282.
The principal objective of this study was to evaluate the chemopreventive and therapeutic effects of a combination of all-trans-retinoic acid (RA) and knockdown of delta-like 1 homologue (Drosophila) (DLK1) on... -
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- Roles of ERK and NF-kappa B in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells
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Kang SH, Lee JH, Choi KH, Rhim BY, Kim K
- KMID: 1838355
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):171-176.
- doi: 10.4196/kjpp.2008.12.4.171
Heat shock proteins (HSPs) serve as molecular chaperones and play a role in cell protection from damage in response to stress stimuli. The aim of this article is to investigate... -
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- Effect of Cholesterol Depletion on Interleukin-8 Production in Human Respiratory Epithelial Cells
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Kim MJ, Hong JY, Lee KE, Kim KW, Sohn MH, Kim KE
- KMID: 2260285
- Allergy Asthma Immunol Res.
- 2013 Nov;5(6):402-408.
- doi: 10.4168/aair.2013.5.6.402
PURPOSE: The lipid entities of cell membranes are components of the immune system and important mediators of inflammation. Despite increasing interest in the function of epithelial cells in inflammation, the... -
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- Role of Extracellular Signal-Regulated Kinase 1/2 and Reactive Oxygen Species in Toll-Like Receptor 2-Mediated Dual-Specificity Phosphatase 4 Expression
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Kim SY, Baek SH
- KMID: 2320038
- Yeungnam Univ J Med.
- 2013 Jun;30(1):10-16.
BACKGROUND: Toll-like receptors (TLRs) are well-known pattern recognition receptors. Among the 13 TLRs, TLR2 is the most known receptor for immune response. It activates mitogen-activated protein kinases (MAPKs), which are... -
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- Work Environments and Exposure to Hazardous Substances in Korean Tire Manufacturing
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Lee N, Lee BK, Jeong S, Yi GY, Shin J
- KMID: 2317056
- Saf Health Work.
- 2012 Jun;3(2):130-139.
OBJECTIVES: The purpose of this study is to evaluate the tire manufacturing work environments extensively and to identify workers' exposure to hazardous substances in various work processes. METHODS: Personal air sampling... -
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- Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1beta in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages
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Won K, Kim SM, Lee SA, Rhim BY, Eo SK, Kim K
- KMID: 2285454
- Korean J Physiol Pharmacol.
- 2012 Dec;16(6):447-453.
- doi: 10.4196/kjpp.2012.16.6.447
TLR6 forms a heterodimer with TLR2 and TLR4. While proinflammatory roles of TLR2 and TLR4 are well documented, the role of TLR6 in inflammation is poorly understood. In order to... -
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- Insulin Like Growth Factor Binding Protein-5 Regulates Excessive Vascular Smooth Muscle Cell Proliferation in Spontaneously Hypertensive Rats via ERK 1/2 Phosphorylation
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Lee DH, Kim JE, Kang YJ
- KMID: 1429387
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):157-162.
- doi: 10.4196/kjpp.2013.17.2.157
Insulin-like growth factor binding proteins (IGFBPs) are important components of insulin growth factor (IGF) signaling pathways. One of the binding proteins, IGFBP-5, enhances the actions of IGF-1, which include the... -
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- Extracellular Nucleotides Can Induce Chemokine (C-C motif) Ligand 2 Expression in Human Vascular Smooth Muscle Cells
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Kim JI, Kim HY, Kim SM, Lee SA, Son YH, Eo SK, Rhim BY, Kim K
- KMID: 2389106
- Korean J Physiol Pharmacol.
- 2011 Feb;15(1):31-36.
To understand the roles of purinergic receptors and cellular molecules below the receptors in the vascular inflammatory response, we determined if extracellular nucleotides up-regulated chemokine expression in vascular smooth muscle... -
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- Effect of EGCG on Expression of Neurogenin 3 via the MAP Kinase Signaling Pathway in AR42J Cells, a Rat Pancreatic Tumor Cell Line
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Kim SO, Choe WK
- KMID: 2268508
- Korean J Nutr.
- 2011 Jun;44(3):196-202.
- doi: 10.4163/kjn.2011.44.3.196
Epigallocatechin gallate (EGCG), or epigallocatechin 3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin. EGCG may be therapeutic for many disorders including diabetics and... -
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- Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCdelta and p38 in Human Airway Epithelial Cells
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Bae CH, Kim HS, Song SY, Kim YD
- KMID: 2134600
- Clin Exp Otorhinolaryngol.
- 2012 Sep;5(3):161-169.
- doi: 10.3342/ceo.2012.5.3.161
OBJECTIVES: Phorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins. MUC16, one of the membrane-bound mucins, is... -
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- High Glucose Induces Connective Tissue Growth Factor Expression and Extracellular Matrix Accumulation in Rat Aorta Vascular Smooth Muscle Cells Via Extracellular Signal-Regulated Kinase 1/2
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Ha YM, Lee DH, Kim M, Kang YJ
- KMID: 2285465
- Korean J Physiol Pharmacol.
- 2013 Aug;17(4):307-314.
- doi: 10.4196/kjpp.2013.17.4.307
Connective tissue growth factor (CTGF) is a potent pro-fibrotic factor, which is implicated in fibrosis through extracellular matrix (ECM) induction in diabetic cardiovascular complications. It is an important downstream mediator... -
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- Epigallocatechin-3-gallate Inhibits LPS-Induced NF-kappaB and MAPK Signaling Pathways in Bone Marrow-Derived Macrophages
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Joo SY, Song YA, Park YL, Myung E, Chung CY, Park KJ, Cho SB, Lee WS, Kim HS, Rew JS, Kim NS, Joo YE
- KMID: 2284263
- Gut Liver.
- 2012 Apr;6(2):188-196.
BACKGROUND/AIMS: Epigallocatechin-3-gallate (EGCG), the primary catechin in green tea, has anti-inflammatory and anti-oxidative properties. The aim of the current study was to characterize the impact of EGCG on lipopolysaccharide (LPS)-induced... -
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- Effects of alpha-lipoic Acid on Differentiation of Thyroid Cancer Cells
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Kim WG, Han DH, Choi HJ, Kim EY, Kim TY, Shong YK, Kim WB
- KMID: 2177858
- J Korean Endocr Soc.
- 2010 Mar;25(1):28-36.
- doi: 10.3803/jkes.2010.25.1.28
BACKGROUND: Induction of re-differentiation is necessary for the proper treatment of patients with recurrent or metastatic differentiated thyroid cancer (DTC) because cancer cells show de-differentiation in about 30% of these... -
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- Induction of Vascular Endothelial Growth Factor Protein by Mycoplasma pneumoniae
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Lee KE, Hong JY, Sohn MH, Kim KW, Park ID, Chang MW, Kim KE
- KMID: 1489491
- Pediatr Allergy Respir Dis.
- 2010 Jun;20(2):100-106.
PURPOSE: Mycoplasma pneumoniae is an extracellular pathogen that attaches to and destroys the ciliated epithelial cells of the respiratory tract. The vascular endothelial growth factor (VEGF) is a critical angiogenic... -
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- Triptolide Inhibits the Proliferation of Immortalized HT22 Hippocampal Cells Via Persistent Activation of Extracellular Signal-Regulated Kinase-1/2 by Down-Regulating Mitogen-Activated Protein Kinase Phosphatase-1 Expression
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Koo HS, Kang SD, Lee JH, Kim NH, Chung HT, Pae HO
- KMID: 2066699
- J Korean Neurosurg Soc.
- 2009 Oct;46(4):389-396.
- doi: 10.3340/jkns.2009.46.4.389
OBJECTIVE: Triptolide (TP) has been reported to suppress the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), of which main function is to inactivate the extracellular signal-regulated kinase-1/2 (ERK-1/2), the... -
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- Duration and Magnitude of Extracellular Signal-Regulated Protein Kinase Phosphorylation Determine Adipogenesis or Osteogenesis in Human Bone Marrow-Derived Stem Cells
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Jung HS, Kim YH, Lee JW
- KMID: 1106452
- Yonsei Med J.
- 2011 Jan;52(1):165-172.
- doi: 10.3349/ymj.2011.52.1.165
PURPOSE: Imbalances between osteogenic and adipogenic differentiation leads to diseases such as osteoporosis. The aim of our study was to demonstrate the differences in extracellular signal-regulated kinase (ERK) phosphorylation during... -
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- Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts
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Kim S, Oh JH, Lee Y, Lee J, Cho KH, Chung JH
- KMID: 946668
- Exp Mol Med.
- 2010 Jan;42(1):38-46.
- doi: 10.3858/emm.2010.42.1.004
Cholesterol is one of major components of cell membrane and plays a role in vesicular trafficking and cellular signaling. We investigated the effects of cholesterol on matrix metalloproteinase-2 (MMP-2) activation... -
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