- Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing
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Park S, Im SA, Kim KH, Lee CK
- KMID: 2150728
- Immune Netw.
- 2011 Dec;11(6):412-415.
- doi: 10.4110/in.2011.11.6.412
Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation... -
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- Polarization of T helper Cells Depends on the Presence of Antigen Presentation
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Kim JG, Hahn YS
- KMID: 1550784
- Korean J Immunol.
- 1999 Jun;21(2):137-145.
There are strong evidences suggesting that Thl and Th2 lymphocytes develop from the same Thlymphocyte precursor under the influence of environmental or genetic factors acting at the level of antigen... -
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- Metformin Suppresses MHC-Restricted Antigen Presentation by Inhibiting Co-Stimulatory Factors and MHC Molecules in APCs
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Shin S, Hyun B, Lee A, Kong H, Han S, Lee CK, Ha NJ, Kim K
- KMID: 2170683
- Biomol Ther.
- 2013 Jan;21(1):35-41.
Metformin is widely used for T2D therapy but its cellular mechanism of action is undefined. Recent studies on the mechanism of metformin in T2D have demonstrated involvement of the immune... -
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- Lectins Isolated from Mushroom Fomitella fraxinea Enhance MHC-restricted Exogenous Antigen Presentation
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Kim H, Cho KM, Gerelchuluun T, Lee JS, Chung KS, Lee CK
- KMID: 2150637
- Immune Netw.
- 2007 Dec;7(4):197-202.
- doi: 10.4110/in.2007.7.4.197
BACKGROUND: Immunomodulators enhancing MHC-restricted antigen presentation would affect many cellular immune reactions mediated by T cells or T cell products. However, modulation of MHC-restricted antigen presentation has received little attention... -
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- Evidence for Direct Inhibition of MHC-Restricted Antigen Processing by Dexamethasone
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Im SA, Gerelchuluun T, Lee CK
- KMID: 2150823
- Immune Netw.
- 2014 Dec;14(6):328-332.
- doi: 10.4110/in.2014.14.6.328
Dexamethasone (Dex) was shown to inhibit the differentiation, maturation, and antigen-presenting function of dendritic cells (DC) when added during DC generation or maturation stages. Here, we examined the direct effects... -
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- Cordyceps militaris Enhances MHC-restricted Antigen Presentation via the Induced Expression of MHC Molecules and Production of Cytokines
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Shin S, Park Y, Kim S, Oh HE, Ko YW, Han S, Lee S, Lee CK, Cho K, Kim K
- KMID: 2150672
- Immune Netw.
- 2010 Aug;10(4):135-143.
- doi: 10.4110/in.2010.10.4.135
BACKGROUND: Cordyceps militarys water extract (CME) has been reported to exert antitumor and immunomodulatory activities in vivo and in vitro. However, the therapeutic mechanism has not yet been elucidated. In... -
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- Current Understanding of Dendritic Cells in Atherosclerosis
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Choi JH
- KMID: 2168221
- Hanyang Med Rev.
- 2013 Feb;33(1):52-58.
- doi: 10.7599/hmr.2013.33.1.52
Dendritic cells (DCs), first identified in 1973, have been shown to be the principal cells involved in antigen presentation to T cells, and are more potent in the presentation of... -
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- Effect of Lipofectin on Antigen-presenting Function and Anti-tumor Activity of Dendritic Cells
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Noh YW, Lim JS
- KMID: 2150620
- Immune Netw.
- 2006 Jun;6(2):102-111.
- doi: 10.4110/in.2006.6.2.102
BACKGROUND: Dendritic cells (DC) are professional antigen-presenting cells in the immune system and can induce T cell response against virus infections, microbial pathogens, and tumors. Therefore, immunization using DC loaded... -
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- Inhibition of Major Histocompatibility Complex (MHC)- Restricted Presentation of Exogenous Antigen in Dendritic Cells by Korean Propolis Components
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Han S, Cho K, Lee S, Lee CK, Song Y, Ha N, Kim K
- KMID: 2150610
- Immune Netw.
- 2005 Sep;5(3):150-156.
- doi: 10.4110/in.2005.5.3.150
BACKGROUND: Dendritic cells (DCs) play a critical role not only in the initiation of immune responses, but also in the induction of immune tolerance. In an effort to regulate immune... -
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- Autophagy in Innate Recognition of Pathogens and Adaptive Immunity
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Oh JE, Lee HK
- KMID: 1120188
- Yonsei Med J.
- 2012 Mar;53(2):241-247.
- doi: 10.3349/ymj.2012.53.2.241
Autophagy is a specialized cellular pathway involved in maintaining homeostasis by degrading long-lived cellular proteins and organelles. Recent studies have demonstrated that autophagy is utilized by immune systems to protect... -
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- Vanilloid Receptor 1 Agonists, Capsaicin and Resiniferatoxin, Enhance MHC Class I-restricted Viral Antigen Presentation in Virus-infected Dendritic Cells
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Lee YH, Im SA, Kim JW, Lee CK
- KMID: 2349884
- Immune Netw.
- 2016 Aug;16(4):233-241.
- doi: 10.4110/in.2016.16.4.233
DCs, like the sensory neurons, express vanilloid receptor 1 (VR1). Here we demonstrate that the VR1 agonists, capsaicin (CP) and resiniferatoxin (RTX), enhance antiviral CTL responses by increasing MHC class... -
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- Lumazine synthase protein cage nanoparticles as antigen delivery nanoplatforms for dendritic cell-based vaccine development
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Ra JS, Shin HH, Kang S, Do Y
- KMID: 1730628
- Clin Exp Vaccine Res.
- 2014 Jul;3(2):227-234.
- doi: 10.7774/cevr.2014.3.2.227
PURPOSE: Protein cages are promising nanoplatform candidates for efficient delivery systems due to their homogenous size and structure with high biocompatibility and biodegradability. In this study, we investigate the potential... -
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- Enhancement of Proliferation and Antigen Presentation of Human B Cells in Vitro by K562 Cells Expressing CD40L
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Park JY, Yoon SH, Kim EK, Yun SO, Sohn HJ, Kim TG
- KMID: 2150630
- Immune Netw.
- 2007 Jun;7(2):80-86.
- doi: 10.4110/in.2007.7.2.80
BACKGROUND: CD40-activated B (CD40-B) cells might be an attractive source of autologous antigen-presenting cells (APCs) for immunotherapy due to the convenience to obtain from peripheral blood and expand in vitro.... -
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- A Case of Generalized Lichen Planus Treated with Topical Pimecrolimus
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Lee YK, Ku BS, Kim YH, Lee CW, Kim KH
- KMID: 1931126
- Korean J Dermatol.
- 2007 Apr;45(4):397-400.
Lichen planus is a chronic papulosquamous disease chracterized by various clinical manifestations of the skin and mucous membrane. Although its etiology is not fully understood, lichen planus has been associated... -
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- Cyclooxygenase Inhibitors, Aspirin and Ibuprofen, Inhibit MHC-restricted Antigen Presentation in Dendritic Cells
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Kim HJ, Lee YH, Im SA, Kim K, Lee CK
- KMID: 2150665
- Immune Netw.
- 2010 Jun;10(3):92-98.
- doi: 10.4110/in.2010.10.3.92
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain, reduce fever and inhibit inflammation. NSAIDs function mainly through inhibition of cyclooxygenase (COX). Growing evidence suggests that NSAIDs also... -
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- Efficient amplification of melanoma-specific CD8+ T cells using artificial antigen presenting complex
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Chang J
- KMID: 1115936
- Exp Mol Med.
- 2006 Dec;38(6):591-598.
In vitro large amplification of tumor-specific cytotoxic T lymphocytes (CTLs) and adoptive transfer of these cells is one of the most promising approaches to treat malignant diseases in which an... -
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- Subdominant H60 antigen-specific CD8 T-cell response precedes dominant H4 antigen-specific response during the initial phase of allogenic skin graft rejection
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Yoo KI, Jeon JY, Ryu SJ, Nam G, Youn H, Choi EY
- KMID: 2155405
- Exp Mol Med.
- 2015 Feb;47(2):e140.
- doi: 10.1038/emm.2014.107
In allogeneic transplantation, including the B6 anti-BALB.B settings, H60 and H4 are two representative dominant minor histocompatibility antigens that induce strong CD8 T-cell responses. With different distribution patterns, H60 expression... -
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- Improvement of DNA vaccination by adjuvants and sophisticated delivery devices: vaccine-platforms for the battle against infectious diseases
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Grunwald T, Ulbert S
- KMID: 2049102
- Clin Exp Vaccine Res.
- 2015 Jan;4(1):1-10.
- doi: 10.7774/cevr.2015.4.1.1
Advantages of DNA vaccination against infectious diseases over more classical immunization methods include the possibilities for rapid manufacture, fast adaptation to newly emerging pathogens and high stability at ambient temperatures.... -
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- Differences in Antigen-presenting Cells in Dermatitis Due to Skin Contact and Ingestion of Lacquer Tree
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Kim KJ, Lee SY, Choi KC, Chung BS
- KMID: 2250973
- Korean J Dermatol.
- 2001 Nov;39(11):1238-1245.
Cutaneous hypersensitivity reaction due to Rhus can develop against antigens delivered through the epidermis(allergic contact dermatitis: ACD) or through the blood vessels(systemic contact dermatitis: SCD). Although the role of Langerhans... -
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- Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination
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Lim S, Koo JH, Choi JM
- KMID: 2154809
- Immune Netw.
- 2016 Feb;16(1):33-43.
- doi: 10.4110/in.2016.16.1.33
Cell-penetrating peptides (CPPs) are short amino acids that have been widely used to deliver macromolecules such as proteins, peptides, DNA, or RNA, to control cellular behavior for therapeutic purposes. CPPs... -
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