- Pharmacogenetics of asthma in children
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Kondo N, Matsui E, Nishimura , Kaneko H
- KMID: 2260414
- Allergy Asthma Immunol Res.
- 2010 Jan;2(1):14-19.
- doi: 10.4168/aair.2010.2.1.14
Allergic diseases such as bronchial asthma and atopic dermatitis develop by a combination of genetic and environmental factors. Several candidate causative genes of asthma and atopy have been reported as... -
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- Phenotype of asthma-chronic obstructive pulmonary disease overlap syndrome
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Rhee CK
- KMID: 2366003
- Korean J Intern Med.
- 2015 Jul;30(4):443-449.
- doi: 10.3904/kjim.2015.30.4.443
Many patients with asthma or chronic obstructive pulmonary disease (COPD) have overlapping characteristics of both diseases. By spirometric definition, patients with both fixed airflow obstruction (AO) and bronchodilator reversibility or... -
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- Anaphylaxis Caused by Benzalkonium in a Nebulizer Solution
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Kim SH, Ahn Y
- KMID: 1733491
- J Korean Med Sci.
- 2004 Apr;19(2):289-290.
- doi: 10.3346/jkms.2004.19.2.289
Benzalkonium chloride (BAC) is commonly used as a bactericidal preservative in nebulizer solutions, and can cause paradoxical onchoconstriction following nebulizing therapy in some asthmatics. We describe a case of anaphylactic... -
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- Single Center Experience of Five Diffuse Panbronchiolitis Patients Clinically Presenting as Severe Asthma
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Park KH, Park HJ, Lee JH, Park JW
- KMID: 2160614
- J Korean Med Sci.
- 2015 Jun;30(6):823-828.
- doi: 10.3346/jkms.2015.30.6.823
Diffuse panbronchiolitis (DPB) is a bronchiolitis affecting the whole lung fields which can be treated by macrolide. Especially East Asian patients are more susceptible to diffuse panbronchiolitis. As asthma and... -
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- Predictors of Asthma Control by Stepwise Treatment in Elderly Asthmatic Patients
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Ban GY, Ye YM, Lee Y, Kim JE, Nam YH, Lee SK, Kim JH, Jung KS, Kim SH, Park HS, the Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group
- KMID: 2164497
- J Korean Med Sci.
- 2015 Aug;30(8):1042-1047.
- doi: 10.3346/jkms.2015.30.8.1042
The geriatric population is increasing, and asthma severity increases with age. We determined the predictors of asthma control, exacerbation, and the factors that affect asthma-specific quality of life (A-QOL) in... -
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- Steroid Response in Refractory Asthmatics
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Jang AS
- KMID: 1776538
- Korean J Intern Med.
- 2012 Jun;27(2):143-148.
- doi: 10.3904/kjim.2012.27.2.143
Inhaled glucocorticosteroids are currently the most effective anti-inflammatory controller medications for treating persistent asthma. The efficacies of glucocorticoids include reducing asthma symptoms, reducing exacerbation frequency, improving quality of life, improving... -
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- An experimental asthma exacerbation following discontinuation of inhaled corticosteroids treatment in patients with controlled asthma
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Choi IS, Koh YI, Jang AS, Chun JH, Lim H
- KMID: 2285973
- J Asthma Allergy Clin Immunol.
- 2001 Feb;21(1):80-89.
BACKGROUND: It has been recognized that cessation of treatment with inhaled corticosteroids evokes a recurrence of symptoms in most asthmatics within a month. OBJECTIVE: To examine whether a useful model of... -
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- Epigenetic regulation in allergic diseases and related studies
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Kuo CH, Hsieh CC, Lee MS, Chang KT, Kuo HF, Hung CH
- KMID: 2397120
- Asia Pac Allergy.
- 2014 Jan;4(1):14-18.
- doi: 10.5415/apallergy.2014.4.1.14
Asthma, a chronic inflammatory disorder of the airway, has features of both heritability as well as environmental influences which can be introduced in utero exposures and modified through aging, and... -
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- Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids
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Postma DS, Dekhuijzen R, van der Molen T, Martin RJ, van Aalderen W, Roche N, Guilbert T, Israel E, van Eickels D, Khalid JM, Herings RM, Overbeek J, Miglio C, Thomas V, Hutton C, Hillyer EV, Price DB
- KMID: 2413385
- Allergy Asthma Immunol Res.
- 2017 Mar;9(2):116-125.
- doi: 10.4168/aair.2017.9.2.116
PURPOSE: Extrafine-particle inhaled corticosteroids (ICS) have greater small airway deposition than standard fine-particle ICS. We sought to compare asthma-related outcomes after patients initiated extrafine-particle ciclesonide or fine-particle ICS (fluticasone propionate... -
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- Addition of Montelukast to Low-Dose Inhaled Corticosteroid Leads to Fewer Exacerbations in Older Patients Than Medium-Dose Inhaled Corticosteroid Monotherapy
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Ye YM, Kim SH, Hur GY, Kim JH, Park JW, Shim JJ, Jung KS, Lee HY, Park HS, PRANA Group
- KMID: 2147952
- Allergy Asthma Immunol Res.
- 2015 Sep;7(5):440-448.
- doi: 10.4168/aair.2015.7.5.440
PURPOSE: There have been few reports regarding the efficacy of antiasthmatics in older patients. To compare the efficacy of the addition of montelukast to low-dose inhaled budesonide (MON-400BUD) versus increasing... -
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- The effects of low dose leukotriene receptor antagonist therapy on airway remodeling and cysteinyl leukotriene expression in a mouse asthma model
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Muz MH, Deveci F, Bulut Y, Ilhan N, Yekeler H, Turgut T
- KMID: 1111403
- Exp Mol Med.
- 2006 Apr;38(2):109-118.
Airway structural changes that occur in patients with asthma in response to persistent inflammation are termed airway remodeling. The cysteinyl leukotrienes (LTC4, D4 and E4) are known to play important... -
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- Effects of Add-On Therapy with NDC-052, an Extract from Magnoliae Flos, in Adult Asthmatic Patients Receiving Inhaled Corticosteroids
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Park CS, Kim TB, Lee JY, Park JY, Lee YC, Jeong SS, Lee YD, Cho YS, Moon HB
- KMID: 1776570
- Korean J Intern Med.
- 2012 Mar;27(1):84-90.
- doi: 10.3904/kjim.2012.27.1.84
BACKGROUND/AIMS: There is a need for new anti-asthmatic medications with fewer side effects. NDC-052, an extract of the medicinal herb Magnoliae flos, which has a long history of clinical use,... -
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- A polymorphism in the histone deacetylase 1 gene is associated with the response to corticosteroids in asthmatics
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Kim MH, Kim SH, Kim YK, Hong SJ, Min KU, Cho SH, Park HW
- KMID: 1780132
- Korean J Intern Med.
- 2013 Nov;28(6):708-714.
- doi: 10.3904/kjim.2013.28.6.708
BACKGROUND/AIMS: Recent investigations suggest that histone deacetylase 1 (HDAC1) and HDAC2 may be target molecules to predict therapeutic responses to corticosteroids. We evaluated the effects of variation in HDAC1 and... -
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- Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
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Lee HY, Rhee CK, Kang JY, Park CK, Lee SY, Kwon SS, Kim YK, Yoon HK
- KMID: 2373777
- Korean J Intern Med.
- 2016 Jan;31(1):89-97.
- doi: 10.3904/kjim.2016.31.1.89
BACKGROUND/AIMS: Asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Peroxisome proliferator-activated receptors have been reported to regulate inflammatory responses in many cells. In this study, we examined the effects... -
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- Addition of Theophylline or Increasing the Dose of Inhaled Corticosteroid in Symptomatic Asthma: A Meta-Analysis of Randomized Controlled Trials
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Wang Y, Lin K, Wang C, Liao X
- KMID: 1779662
- Yonsei Med J.
- 2011 Mar;52(2):268-275.
- doi: 10.3349/ymj.2011.52.2.268
PURPOSE: Low-dose theophylline has anti-inflammatory effects. The aim of this study was to evaluate the effects of adding theophylline compared with increasing the dose of inhaled corticosteroid (ICS) on symptomatic... -
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- The Soluble Tumor Necrosis Factor-Alpha Receptor Suppresses Airway Inflammation in a Murine Model of Acute Asthma
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Nam HS, Lee SY, Kim SJ, Kim JS, Kwon SS, Kim YK, Kim KH, Moon HS, Song JS, Park SH, Kim SC
- KMID: 1758619
- Yonsei Med J.
- 2009 Aug;50(4):569-575.
- doi: 10.3349/ymj.2009.50.4.569
PURPOSE: Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in many aspects of the airway pathology in asthma. TNF-alpha blocking strategies are now being tried in... -
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- The Effect of CpG-Oligodeoxynucleotides with Different Backbone Structures and 3' Hexameric Deoxyriboguanosine Run Conjugation on the Treatment of Asthma in Mice
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Chang YS, Kim YK, Kwon HS, Park HW, Min KU, Kim YY, Cho SH
- KMID: 1782007
- J Korean Med Sci.
- 2009 Oct;24(5):860-866.
- doi: 10.3346/jkms.2009.24.5.860
CpG-Oligodeoxynucleotide (ODN) has two backbones. Phosphorothioate backbone (PS) shows a strong immunostimulating effect while phosphodiester (PE) shows little in vivo. 3' hexameric deoxyriboguanosine-run (3' dG6-run) conjugation to PE CpG-ODN has... -
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