Korean J Intern Med.
2012 Mar;27(1):84-90. 10.3904/kjim.2012.27.1.84.
Effects of Add-On Therapy with NDC-052, an Extract from Magnoliae Flos, in Adult Asthmatic Patients Receiving Inhaled Corticosteroids
- Affiliations
-
- 1Department of Internal Medicine, Heaundae Paik Hospital, Inje University, Busan, Korea.
- 2Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. hbmoon@amc.seoul.kr
- 3Department of Pulmonary, Allergy and Critical Care Medicine, Hallym University College of Medicine, Chuncheon, Korea.
- 4Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
- 5Department of Internal Medicine, Research Center for Pulmonary Disorders, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea.
- 6Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea.
- 7Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
- KMID: 1776570
- DOI: http://doi.org/10.3904/kjim.2012.27.1.84
Abstract
- BACKGROUND/AIMS
There is a need for new anti-asthmatic medications with fewer side effects. NDC-052, an extract of the medicinal herb Magnoliae flos, which has a long history of clinical use, was recently found to have anti-inflammatory effects. Herein, we evaluated the effects of NDC-052 as an add-on therapy in patients with mild to moderate asthma using inhaled corticosteroids (ICS).
METHODS
In a non-comparative, multi-center trial, 148 patients taking ICS received NDC-052 for eight weeks. We evaluated their forced expiratory volume in one second (FEV1), morning and evening peak expiratory flow rate (AM and PM PEFR), AM/PM asthma symptom scores, visual analogue symptom (VAS) scores, night-time wakening, frequency of short-acting beta2-agonist usage, and adverse events.
RESULTS
After eight weeks, both AM and PM PEFRs were significantly improved. Asthma symptom scores, VAS scores, the frequency of nights without awakening, and the frequency of beta2-agonist use were also reduced. Most of the adverse drug reactions were mild and resolved spontaneously.
CONCLUSIONS
The addition of NDC-052 to ICS had a beneficial effect on asthma control in patients with mild to moderate asthma, with good tolerability and fewer side effects. Further studies are necessary to evaluate the effects of NDC-052 in patients with severe and/or refractory asthma.
Keyword
MeSH Terms
-
Administration, Inhalation
Adrenal Cortex Hormones/*administration & dosage
Adrenergic beta-2 Receptor Agonists/therapeutic use
Adult
Anti-Asthmatic Agents/administration & dosage/*therapeutic use
Asthma/diagnosis/*drug therapy/physiopathology
Drug Therapy, Combination
Drugs, Chinese Herbal/*therapeutic use
Female
Forced Expiratory Volume
Humans
Lung/drug effects/physiopathology
*Magnolia
Male
Middle Aged
Peak Expiratory Flow Rate
Prospective Studies
Republic of Korea
Severity of Illness Index
Time Factors
Treatment Outcome
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