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Activation of Toll-like Receptors 1, 2, 4, 5, and 7 on Human Melanocytes Modulate Pigmentation

Jin SH, Kang HY

Human melanocytes are not simply pigment-producing cells. It may be part of the inflammatory response, during which the pigmentary system may produce more melanin or suppress melanization. Toll-like receptors (TLRs)...
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Vitiligo Coexistent with Nevus Depigmentosus: This Was Treated with Narrow-Band UVB and These Lesions Were Followed Using the Mexameter(R), a Pigment-Measuring Device

Hwang SW, Kang JH, Jung SY, Choi JH, Seo JK, Lee D, Sung HS

Nevus depigmentosus (ND) is a congenital, non-progressive, hypopigmented lesion that is usually stable throughout an affected individual's lifetime. The clinical features of vitiligo are similar to those of ND, but...
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A Case of Sweet's Panniculitis Associated with Spinal Metastasis from Prostate Cancer

Kim J, Choi YJ, Oh SH, Lee KH

Sweet's panniculitis is a rare variant of Sweet's syndrome in which neutrophilic infiltrate can be found either in the subcutaneous fat or in both the dermis and the subcutaneous tissue....
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A Case of Primary Cutaneous Mucinous Carcinoma with Neuroendocrine Differentiation

Kim JB, Choi JH, Kim JH, Park HJ, Lee JS, Joh OJ, Song KY

Primary cutaneous mucinous carcinoma is a rare malignant tumor that originates from the deepest portion of the eccrine sweat duct. Common sites of involvement are the face and scalp. Biopsy...
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Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease

Na SY, Choi M, Kim MJ, Lee JH, Cho S

Elastosis perforans serpiginosa (EPS) is a rare reactive perforating dermatosis that is characterized by the transepidermal elimination of abnormal elastic fibers. Penicillamine, which is one of the clear triggers for...
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Idiopathic Multiple Eruptive Milia Occurred in Unusual Sites

Cho E, Cho SH, Lee JD

Milia are small, white, benign keratinous cysts that are frequently encountered. Multiple eruptive milia are rare, and are characterized by the development of milia that are more extensive in number and...
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Unusual Presentation of Obesity-associated Dermatoses: Acanthosis Nigricans Involving Both Auricles

Lee YB, Lee JD, Cho SH

Acanthosis nigricans is prevalent in the general population and is the most common dermatological manifestation of obesity. It is typically observed in the flexural areas such as the neck, axillae,...
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An Unusual Case of Congenital Dermal Melanocytosis

Lee S, Kim DH, Lee G, Whang KU, Lee JS, Park YL

Dermal melanocytosis is characterized by the presence of ectopic melanocytes in the dermis. The most common forms include the Mongolian spot, blue nevus, nevus of Ota, and nevus of Ito....
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Atrophying Pityriasis Versicolor: Is This a New Variant of Pityriasis Versicolor?

Yang YS, Shin MK, Haw CR

An atypical clinical form of pityriasis versicolor has been infrequently reported, in which cutaneous atrophy is associated with individual pityriasis versicolor lesions. The pathogenesis of this atrophy remains unclear, but...
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Multiple Endocrine Neoplasia Type 2B: Early Diagnosis by Multiple Mucosal Neuroma and Its DNA Analysis

Lee MJ, Chung KH, Park JS, Chung H, Jang HC, Kim JW

Multiple endocrine neoplasia type 2B (MEN 2B) is a rare disease caused by germline mutations in the RET proto-oncogene and is transmitted in an autosomal dominant fashion. It is characterized...
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Lymphomatoid Papulosis Followed by Anaplastic Large Cell Lymphoma in a Pediatric Patient

Min JA, Oh ST, Kim JE, Cho BK, Chung NG, Park HJ

Lymphomatoid papulosis (LyP) is a benign, self-healing, papular eruption that can wax and wane over time. Transformation to T-cell lymphoma has been well documented in 10% to 20% of adults...
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Multiple Epidermal Cysts in Lowe Syndrome

Won JH, Lee MJ, Park JS, Chung H, Kim JK, Shim JS

Lowe syndrome is a rare genetic disease that appears to cause various clinical symptoms involving the eye, nervous system, and kidney. While a mutation of the OCRL1 gene is known...
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Erdheim-Chester Disease

Kim MS, Kim CH, Choi SJ, Won CH, Chang SE, Lee MW, Choi JH, Moon KC

Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis of unknown etiology, characterized by multi-organ involvement. ECD is usually diagnosed on the basis of characteristic radiologic and histopathological findings. Lesions...
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Subcutaneous Sarcoidosis with Plantar Involvement

Celik G, Ciledag A, Akin P, Simsek Y, Kaya A, Numanoglu , Saglik YY, Boyvat A, Erekul S

Sarcoidosis is a multisystem granulomatous disorder of an unknown etiology. Subcutaneous sarcoidosis is a rare manifestation of sarcoidosis, and plantar involvement is extremely rare and there is only one such...
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A Case of Trichogerminoma

Kim M, Choi M, Hong JS, Lee JH, Cho S

Trichogerminoma is a rare neoplasm which was first described in 1992 and there is still controversy over its inclusion into the spectrum of trichoblastoma. A 79-year-old woman presented with a...
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Kasabach-Merritt Syndrome Arising from Tufted Angioma Successfully Treated with Systemic Corticosteroid

Kim T, Roh MR, Cho S, Chung KY

We report a case of Kasabach-Merritt syndrome arising from a tufted angioma successfully treated with systemic corticosteroid. A 2-month-old male infant presented with a palm-sized, erythematous induration on his left...
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A Case of Pyoderma Gangrenosum with Ulcerative Colitis Treated with Mesalazine

Lee JI, Park HJ, Lee JY, Cho BK

Pyoderma gangrenosum (PG) manifests as recurrent deep ulceration of the skin and PG is associated with a variety of disorders. Approximately 30% of the cases of PG develop in patients...
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A Case of Gardner's Syndrome Associated with Desmoid Tumor

Chung J, Namkoong S, Jung KE, Park JW, Park BC, Cinn YW, Kim MH

Desmoid tumors are uncommon benign neoplasm of the fibroblasts. They occur rarely in the general population, but they are comparatively common in patients with familial polyposis coli with or without...
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Chemokine Receptor CCR3 Expression in Malignant Cutaneous Tumors

Lee YJ, Kim DH, Lee SH, Nam HS, Roh MR, Cho MK

BACKGROUND: Chemokines and their receptors are important players in tumorigenesis by facilitating tumor proliferation and metastasis. Little is known about the possible function of chemokine receptors in relation to the...
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Diagnostic Usefulness of the Serum-Specific IgE, the Skin Prick Test and the Atopy Patch Test Compared with That of the Oral Food Challenge Test

Chung BY, Kim HO, Park CW, Lee CH

BACKGROUND: Atopic dermatitis (AD) is frequently associated with food allergies. In addition to the skin prick test (SPT) and serum-specific IgE, the atopy patch test (APT) has been introduced as...
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