Ann Dermatol.
2010 Nov;22(4):468-471. 10.5021/ad.2010.22.4.468.
Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease
- Affiliations
-
- 1Department of Dermatology, Seoul National University Boramae Hospital, 425 Shindaebang 2-dong, Dongjak-gu, Seoul 156-707, Korea. sycho@snu.ac.kr
- KMID: 2266191
- DOI: http://doi.org/10.5021/ad.2010.22.4.468
Abstract
- Elastosis perforans serpiginosa (EPS) is a rare reactive perforating dermatosis that is characterized by the transepidermal elimination of abnormal elastic fibers. Penicillamine, which is one of the clear triggers for EPS, is a heavy metal chelator that is primarily used for disorders such as cystinuria and Wilson's disease. It may cause alterations in the dermal elastic tissue such as pseudo-pseudoxanthoma elasticum, acquired cutis laxa, EPS and anetoderma. Herein we present a case of cutis laxa and EPS in a 34-year-old man who was previously on a long-term, high-dose of penicillamine for Wilson's disease. The combination of EPS and cutis laxa induced by penicillamine has rarely been reported and we report the first such case in Korea.
