- Effect of Nitric Oxide on ADP-ribose Pyrophosphatase Activity
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Kim JH
- KMID: 1846706
- Immune Netw.
- 2005 Dec;5(4):199-204.
- doi: 10.4110/in.2005.5.4.199
BACKGROUND: ADP-ribosyl pyrophosphatases (ADPRase) has been known to catalyze the hydrolysis of ADP-ribose to ribose-5-phosphate and AMP. The role of ADPRase has been suggested to sanitize the cell by removing... -
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- A Nudix Hydrolase Protein, Ysa1, Regulates Oxidative Stress Response and Antifungal Drug Susceptibility in Cryptococcus neoformans
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Lee KT, Kwon H, Lee D, Bahn YS
- KMID: 2312723
- Mycobiology.
- 2014 Mar;42(1):52-58.
A nucleoside diphosphate-linked moiety X (Nudix) hydrolase-like gene, YSA1, has been identified as one of the gromwell plant extract-responsive genes in Cryptococcus neoformans. Ysa1 is known to control intracellular concentrations... -
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- Enzymatic characterization of Mycobacterium smegmatis ADP-ribosyltransferase
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Song EK, Lee SY, Cho JK, Han MK, Lee HH
- KMID: 2054972
- J Bacteriol Virol.
- 2003 Dec;33(4):293-300.
ADP-ribosyltransferase (ADPRT) catalyzes the reaction in which the ADP-ribose moiety of beta-NAD+ is transferred to specific amino acid residues in target proteins. The ADPRT of Mycobacterium smegmatis has been known... -
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- The Anti-fibrotic Effect of Nilotinib on Tenon's Capsule Fibroblasts in Vitro
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Kang JW, Jeong JH, Moon NJ
- KMID: 2413818
- J Korean Ophthalmol Soc.
- 2018 Jun;59(6):549-555.
- doi: 10.3341/jkos.2018.59.6.549
PURPOSE: To evaluate the anti-fibrotic effects of nilotinib on the survival of cultured human Tenon's capsule fibroblasts (HTFs). METHODS: HTF primary cultures were obtained from samples following glaucoma surgery. Primarily cultured... -
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- Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells
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Lee HM, Moon A
- KMID: 2170542
- Biomol Ther.
- 2016 Jan;24(1):62-66.
- doi: 10.4062/biomolther.2015.172
Amygdalin, D-mandelonitrile-beta-D-glucoside-6-beta-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor... -
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- Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1
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Hasan MA, Sultan MT, Ahn WG, Kim YJ, Jang JH, Hong CW, Song DK
- KMID: 2285552
- Korean J Physiol Pharmacol.
- 2014 Dec;18(6):497-502.
- doi: 10.4196/kjpp.2014.18.6.497
Extracellular nicotinamide adenine dinucleotide (NAD) cleaving activity of a particular cell type determines the rate of the degradation of extracellular NAD with formation of metabolites in the vicinity of the... -
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- Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity
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Yoon SP, Kim J
- KMID: 2353341
- Anat Cell Biol.
- 2016 Sep;49(3):165-176.
- doi: 10.5115/acb.2016.49.3.165
Enhanced oxidative stress is a hallmark of cisplatin nephrotoxicity, and inhibition of poly(ADP-ribose) polymerase 1 (PARP1) attenuates oxidative stress during cisplatin nephrotoxicity; however, the precise mechanisms behind its action remain... -
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- Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells
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Song H, Yoon SP, Kim J
- KMID: 2308914
- Anat Cell Biol.
- 2016 Jun;49(2):79-87.
- doi: 10.5115/acb.2016.49.2.79
After renal injury, selective damage occurs in the proximal tubules as a result of inhibition of glycolysis. The molecular mechanism of damage is not known. Poly(ADP-ribose) polymerase (PARP) activation plays... -
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- Current state and outlook for drug repositioning anticipated in the field of ovarian cancer
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Kobayashi , Banno K, Kunitomi H, Tominaga E, Aoki D
- KMID: 2429579
- J Gynecol Oncol.
- 2019 Jan;30(1):e10.
- doi: 10.3802/jgo.2019.30.e10
Ovarian cancer is the seventh most common cancer and the eighth most common cause of cancer mortality in women. Although standard chemotherapy is the established treatment for ovarian cancer, the... -
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- Cisplatin-Induced Apoptosis by Cisplatin in Human Glioblastoma Cell Line
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Park JT, Kim TY
- KMID: 2018577
- J Korean Neurosurg Soc.
- 2002 Jun;31(6):574-584.
OBJECTIVE: This study is designed to evaluate the apoptotic signaling pathway of anticancer agent (cisplatin) on human malignant glioblastoma A172 and T98G cells, bearing wild type p53 and mutated p53,... -
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- 15-Lipoxygenase-1 Induced by Interleukin-4 Mediates Apoptosis in Oral Cavity Cancer Cells
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Kim JH, Lee JG, Yoon JH, Lee KW, Seo HS, Kim KS
- KMID: 2115502
- Korean J Otolaryngol-Head Neck Surg.
- 2005 Dec;48(12):1512-1518.
BACKGROUND AND OBJECTIVES: In oral cavity cancer (OCC) cells, the effects of interleukin-4 (IL-4) are various according to the cell specificity. However, if IL-4 induces apoptosis on OCC cells, the... -
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- Increased Poly (ADP-ribose) Polymerase Activation in the 6-Hydroxydopamine Induced Dopaminergic Neuronal Cell Death
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Kang JH, Kang SY, Park SY, Kang HK, Park DB, Lee YK, Koh JY
- KMID: 2343084
- J Korean Neurol Assoc.
- 2004 Aug;22(4):352-359.
BACKGROUND: The pathological hallmark of Parkinson's disease (PD) is dopaminergic cell death in the substantia nigra (SN), but the cause of cell death is unknown. 6-Hydroxydopamine (6-OHDA) is one of... -
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- Effects of the Specific COX-2 Inhibitor, Celecoxib, on Paclitaxel-Induced Apoptosis in SK-OV-3 Epithelial Ovarian Cancer Cell Line
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Ahn YG, Kim SS, Chun WJ, Hwang BC, Song YJ, Soh EJ, Hwang JY, Cho JS, Lee DH
- KMID: 2272626
- Korean J Obstet Gynecol.
- 2005 Jul;48(7):1673-1685.
OBJECTIVE: In vitro studies have revealed that treatment of various human cancer cell lines with specific cyclooxygenase 2 (COX-2) inhibitors induces apoptotic cell death. The goal of this article is... -
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- In Vitro Responses of SK-OV-3 Ovarian Cancer Cell Lines to Tamoxifen and Celecoxib
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Ahn YG, Kim SS, Chun WJ, Cheong IY, Song YJ, Soh EJ, Hwang JY, Cho JS, Lee DH
- KMID: 2272651
- Korean J Obstet Gynecol.
- 2005 Aug;48(8):1905-1916.
OBJECTIVE: There are some evidences that some epithelial ovarian cancer cells respond to hormonal therapy. And in vitro studies have revealed that treatment of various human cancer cell lines with... -
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- Synergistic Effect of COX-2 Inhibitor on Paclitaxel-Induced Apoptosis in the Human Ovarian Cancer Cell Line OVCAR-3
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Kim HJ, Yim GW, Nam EJ, Kim YT
- KMID: 2167661
- Cancer Res Treat.
- 2014 Jan;46(1):81-92.
PURPOSE: Celecoxib, a highly selective cyclooxygenase-2 inhibitor, regulates apoptosis of several types of human cancer cells. The purpose of this study was to investigate whether celecoxib in combination with paclitaxel... -
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- Methanol Extracts of Codium fragile Induces Apoptosis through G1/S Cell Cycle Arrest in FaDu Human Hypopharynx Squamous Carcinoma Cells
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Lee SA, Park BR, Moon SM, Kim DK, Kim CS
- KMID: 2437356
- Int J Oral Biol.
- 2018 Jun;43(2):61-68.
- doi: 10.11620/IJOB.2018.43.2.061
Codium fragile (Suringar) Hariot is an edible green seaweed that belong to the Codiaceae family and has been used in Oriental medicine for the treatment of enterobiasis, dropsy, and dysuria.... -
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- Mycophenolic acid mediated mitochondrial membrane potential transition change lead to T lymphocyte apoptosis
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Choi SJ, Lee HK, Kim NH, Chung SY
- KMID: 1445743
- J Korean Surg Soc.
- 2011 Oct;81(4):235-241.
- doi: 10.4174/jkss.2011.81.4.235
PURPOSE: This study demonstrated that apoptosis induced by mycophenolic acid (MPA) is mediated by mitochondrial membrane potential transition (MPT) changes in Jurkat cells. METHODS: Cell viability and MPT changes were measured... -
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- The Role of Poly(ADP-ribose) Polymerase-1 in Ventilator-Induced Lung Injury
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Kim JH, Yoon DW, Hur GY, Jung KH, Lee SY, Lee SY, Shin C, Shim JJ, In KH, Yoo SH, Kang KH
- KMID: 1719370
- Tuberc Respir Dis.
- 2006 Apr;60(4):451-463.
- doi: 10.4046/trd.2006.60.4.451
BACKGROUND: Reactive oxygen species (ROS) take center stage as executers in ventilator-induced lung injury (VILI). The protein with DNA-damage scanning activity, poly (ADP-ribose) polymerase-1 (PARP1), signals DNA rupture and participates... -
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- Neuroprotective Effect of N-acetylcysteine in an Asphyxial Cardiac Arrest Model of Rats
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Park SH, Choi CR, Oh DR, Choi SM, Kim SK
- KMID: 2331322
- J Korean Soc Emerg Med.
- 2001 Dec;12(4):447-456.
BACKGROUND: A major pathway leading toward neuronal injury following ischemia-reperfusion of the brain involves elevation of extracellular glutamate and activation of glutamate receptors, with a subsequent increase in intracellular calcium,... -
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- Protective effects of perilla oil and alpha linolenic acid on SH-SY5Y neuronal cell death induced by hydrogen peroxide
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Lee AY, Choi JM, Lee MH, Lee J, Lee S, Cho EJ
- KMID: 2407805
- Nutr Res Pract.
- 2018 Apr;12(2):93-100.
- doi: 10.4162/nrp.2018.12.2.93
BACKGROUND/OBJECTIVE: Oxidative stress plays a key role in neuronal cell damage, which is associated with neurodegenerative disease. The aim of present study was to investigate the neuroprotective effects of perilla... -
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