- Changes in the Histone Acetylation Patterns during the Development of the Nervous System
-
Cho B, Kim HJ, Kim H, Sun W
- KMID: 2052819
- Exp Neurobiol.
- 2011 Jun;20(2):81-84.
- doi: 10.5607/en.2011.20.2.81
Epigenetic modification such as DNA methylation and histone acetylation plays essential roles in many aspects of cellular function and development of animals. There is an increasing amounts of evidence for... -
- CITED
-
- Close
- SHARE
-
- Close
- Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men
-
Kim JH, Jee BC, Lee JM, Suh CS, Kim SH
- KMID: 1799499
- Yonsei Med J.
- 2014 Sep;55(5):1333-1340.
- doi: 10.3349/ymj.2014.55.5.1333
PURPOSE: The aim of this work was to evaluate nuclear histone acetylation level and total histone acetyltransferase (HAT) and deacetylase (HDAC) activity in ejaculated sperm and their relevance to conventional... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells
-
Kim D, Kim Y, Kim Y
- KMID: 2468812
- J Cancer Prev.
- 2019 Dec;24(4):224-232.
- doi: 10.15430/JCP.2019.24.4.224
BACKGROUND: Beta-carotene (BC) is a carotenoid which exerts anti-cancer effects in several types of cancer, including colorectal cancer. Epigenetic modifications of genes, such as histone deacetylation and DNA hypermethylation, have... -
- CITED
-
- Close
- SHARE
-
- Close
- The Role of N-Acetyl Transferases on Isoniazid Resistance from Mycobacterium tuberculosis and Human: An In Silico Approach
-
Unissa AN, Sukumar S, Hanna LE
- KMID: 2385040
- Tuberc Respir Dis.
- 2017 Jul;80(3):255-264.
- doi: 10.4046/trd.2017.80.3.255
BACKGROUND: N-acetyl transferase (NAT) inactivates the pro-drug isoniazid (INH) to N-acetyl INH through a process of acetylation, and confers low-level resistance to INH in Mycobacterium tuberculosis (MTB). Similar to NAT... -
- CITED
-
- Close
- SHARE
-
- Close
- Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells
-
Chung S, Hwang JT, Park JH, Choi HK
- KMID: 2453283
- Nutr Res Pract.
- 2019 Jun;13(3):196-204.
- doi: 10.4162/nrp.2019.13.3.196
BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease triggered by epigenetic alterations, including lysine acetylation at histone or non-histone proteins, affecting the stability or transcription of lipogenic... -
- CITED
-
- Close
- SHARE
-
- Close
- Partial Hepatectomy in Acetylation-Deficient BubR1 Mice Corroborates that Chromosome Missegregation Initiates Tumorigenesis
-
Lee YK, Park I, Lee H
- KMID: 2384255
- Endocrinol Metab.
- 2014 Dec;29(4):561-566.
- doi: 10.3803/EnM.2014.29.4.561
BACKGROUND: Aneuploidy has been suggested as one of the major causes of cancer from the time of Boveri. In support of this notion, many studies have shown that cancer cells... -
- CITED
-
- Close
- SHARE
-
- Close
- Modulation of gene expression dynamics by co-transcriptional histone methylations
-
Woo H, Ha SD, Lee SB, Buratowski S, Kim T
- KMID: 2382717
- Exp Mol Med.
- 2017 Apr;49(4):e326.
- doi: 10.1038/emm.2017.19
Co-transcriptional methylations of histone H3 at lysines 4 and 36, highly conserved methyl marks from yeast to humans, have profound roles in regulation of histone acetylation. These modifications function to... -
- CITED
-
- Close
- SHARE
-
- Close
- Differential Histone Acetylation in Sub-Regions of Bed Nucleus of the Stria Terminalis Underlies Fear Consolidation and Extinction
-
Ranjan V, Singh S, Siddiqui S, Tripathi S, Khan MY, Prakash A
- KMID: 2378651
- Psychiatry Investig.
- 2017 May;14(3):350-359.
- doi: 10.4306/pi.2017.14.3.350
OBJECTIVE: The hallmark of anxiety disorders is excessive fear. Previous studies have suggested that selective neural projections from Basal nucleus of stria terminalis (BNST) to amygdala and vice-versa precisely control... -
- CITED
-
- Close
- SHARE
-
- Close
- HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice
-
Kim T, Song S, Park Y, Kang S, Seo H
- KMID: 2458548
- Exp Neurobiol.
- 2019 Aug;28(4):504-515.
- doi: 10.5607/en.2019.28.4.504
Parkinson’s disease (PD) is one of the late-onset neurodegenerative movement disorder. Major pathological markers of PD include progressive loss of dopaminergic neurons, Lewy body formation, genetic mutations, and environmental factors.... -
- CITED
-
- Close
- SHARE
-
- Close
- Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity
-
Yoon SP, Kim J
- KMID: 2353341
- Anat Cell Biol.
- 2016 Sep;49(3):165-176.
- doi: 10.5115/acb.2016.49.3.165
Enhanced oxidative stress is a hallmark of cisplatin nephrotoxicity, and inhibition of poly(ADP-ribose) polymerase 1 (PARP1) attenuates oxidative stress during cisplatin nephrotoxicity; however, the precise mechanisms behind its action remain... -
- CITED
-
- Close
- SHARE
-
- Close
- Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
-
Park S, Park JA, Jeon JH, Lee Y
- KMID: 2456216
- Biomol Ther.
- 2019 Sep;27(5):423-434.
- doi: 10.4062/biomolther.2019.051
HSP90 is a molecular chaperone that increases the stability of client proteins. Cancer cells show higher HSP90 expression than normal cells because many client proteins play an important role in... -
- CITED
-
- Close
- SHARE
-
- Close
- Epigenetic Regulation of BDNF Gene in Response to Stress
-
Fuchikami , Yamamoto S, Morinobu S, Takei S, Yamawaki S
- KMID: 2315911
- Psychiatry Investig.
- 2010 Dec;7(4):251-256.
Neuronal plasticity induced by changes in synaptic morphology and function is well known to play a pivotal role in leaning and memory as well as adaptation to stress. It is... -
- CITED
-
- Close
- SHARE
-
- Close
- A Novel Osteogenic Activity of Suberoylanilide Hydroxamic Acid is Synergized by BMP-2
-
Lee ZH, Kim HJ, Ryoo HM
- KMID: 2170088
- J Bone Metab.
- 2015 May;22(2):51-56.
- doi: 10.11005/jbm.2015.22.2.51
BACKGROUND: Many histone deacetylase (HDAC) inhibitors are well recognized as potential anti-cancer drugs. Inhibition of HDACs induces temporal transcription or epigenetic control, thus regulating many different biological responses. Here, we... -
- CITED
-
- Close
- SHARE
-
- Close
- Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells
-
Choi BH, Lee DH, Kim J, Kang JH, Park CS
- KMID: 2365710
- Int Neurourol J.
- 2016 Sep;20(3):182-187.
- doi: 10.5213/inj.1632718.359
Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5'-AMP-activated protein kinase (AMPK) activators such... -
- CITED
-
- Close
- SHARE
-
- Close
- Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation
-
Lee S
- KMID: 2317819
- Toxicol Res.
- 2013 Jun;29(2):81-86.
Toxicoproteomics integrates the proteomic knowledge into toxicology by enabling protein quantification in biofluids and tissues, thus taking toxicological research to the next level. Post-translational modification (PTM) alters the three-dimensional (3D)... -
- CITED
-
- Close
- SHARE
-
- Close
- Activation of ATM-dependent DNA Damage Signal Pathway by a Histone Deacetylase Inhibitor, Trichostatin A
-
Lee JS
- KMID: 1522935
- Cancer Res Treat.
- 2007 Sep;39(3):125-130.
PURPOSE: Ataxia-telangiectasia mutated (ATM) kinase regulates diverse cellular DNA damage responses, including genome surveillance, cell growth, and gene expression. While the role of histone acetylation/deacetylation in gene expression is well... -
- CITED
-
- Close
- SHARE
-
- Close
- Histone lysine demethylases in mammalian embryonic development
-
Shen H, Xu W, Lan F
- KMID: 2382716
- Exp Mol Med.
- 2017 Apr;49(4):e325.
- doi: 10.1038/emm.2017.57
Post-translational modifications, such as methylation, acetylation and phosphorylation, of histone proteins play important roles in regulating dynamic chromatin structure. Histone demethylation has become one of the most active research areas... -
- CITED
-
- Close
- SHARE
-
- Close
- The Neuroprotective Effect of Treatment of Valproic Acid in Acute Spinal Cord Injury
-
Yu SH, Cho DC, Kim KT, Nam KH, Cho HJ, Sung JK
- KMID: 2066909
- J Korean Neurosurg Soc.
- 2012 Apr;51(4):191-198.
- doi: 10.3340/jkns.2012.51.4.191
OBJECTIVE: Valproic acid (VPA), as known as histone deacetylase inhibitor, has neuroprotective effects. This study investigated the histological changes and functional recovery from spinal cord injury (SCI) associated with VPA... -
- CITED
-
- Close
- SHARE
-
- Close
- CYP1A2 activity as a risk factor for bladder cancer
-
Lee SW, Jang IJ, Shin SG, Lee KH, Yim DS, Kim SW, Oh SJ, Lee SH
- KMID: 644840
- J Korean Med Sci.
- 1994 Dec;9(6):482-489.
- doi: 10.3346/jkms.1994.9.6.482
CYP1A2, CYP2D6 and N-acetyltransferase activities were estimated in 100 patients with bladder cancer and 84 control subjects from measurements of theophylline, metoprolol and isoniazid and their metabolites in urine, respectively.... -
- CITED
-
- Close
- SHARE
-
- Close
- HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases
-
Yoon S, Eom GH
- KMID: 2152651
- Chonnam Med J.
- 2016 Jan;52(1):1-11.
- doi: 10.4068/cmj.2016.52.1.1
Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also post-transcriptional modifiers that regulate the protein acetylation implicated in... -
- CITED
-
- Close
- SHARE
-
- Close
