- (E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone displays suppression of inflammatory responses via inhibition of Src, Syk, and NF-kappaB
-
Kim Y, Jeong EJ, Han Lee IS, Kim MY, Cho JY
- KMID: 2150478
- Korean J Physiol Pharmacol.
- 2016 Jan;20(1):91-99.
- doi: 10.4196/kjpp.2016.20.1.91
(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone (MPP) is an aldol condensation product resulting from pyrrole-2-carbaldehyde and m- and p- substituted acetophenones. However, its biological activity has not yet been evaluated. Since it has been reported... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of Apocynin on Acute Lung Injury in Rats Given Interleukin-1alpha Intratracheally
-
Lee YM
- KMID: 2319532
- Tuberc Respir Dis.
- 2011 Jun;70(6):482-489.
BACKGROUND: Based on the assertion that apocynin diminishes acute lung injury (ALI) by inhibition of NADPH oxidase, the effect of apocynin was tested in interleukin-1alpha (IL-1)-induced ALI in rats. METHODS: IL-1... -
- CITED
-
- Close
- SHARE
-
- Close
- Cilostazol Attenuates 4-hydroxynonenal-enhanced CD36 Expression on Murine Macrophages via Inhibition of NADPH Oxidase-derived Reactive Oxygen Species Production
-
Yun MR, Park HM, Seo KW, Kim CE, Yoon JW, Kim CD
- KMID: 2071658
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):99-106.
- doi: 10.4196/kjpp.2009.13.2.99
Although anti-atherogenic effects of cilostazol have been suggested, its effects on the expression of SR in macrophages are unclear. This study investigated the role of cilostazol on CD36 expression... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of ATP and LTC4 on hypoxic pulmonary vasoconstriction in isolated rat lungs
-
Rho JY, Shin HY, Kim HC, Lee JW, Kim SD
- KMID: 1765452
- Korean J Anesthesiol.
- 2009 Oct;57(4):472-482.
- doi: 10.4097/kjae.2009.57.4.472
BACKGROUND: Hypoxic pulmonary vasoconstriction (HPV) is unique to pulmonary circulation but the mechanism remains elusive. Red blood cells (RBCs) are known to augment HPV and to release more ATP as... -
- CITED
-
- Close
- SHARE
-
- Close
- Arachidonic Acid Activates K+-Cl--cotransport in HepG2 Human Hepatoblastoma Cells
-
Lee YS
- KMID: 1982575
- Korean J Physiol Pharmacol.
- 2009 Oct;13(5):401-408.
- doi: 10.4196/kjpp.2009.13.5.401
K+-Cl--cotransport (KCC) has been reported to have various cellular functions, including proliferation and apoptosis of human cancer cells. However, the signal transduction pathways that control the activity of KCC are... -
- CITED
-
- Close
- SHARE
-
- Close
- Migration of Vascular Smooth Muscle Cells by High Glucose is Reactive Oxygen Dependent
-
An YS, Kwon JH, Kang YH, Kim IJ, Kim YK, Son SM
- KMID: 2298089
- Korean Diabetes J.
- 2008 Jun;32(3):185-195.
- doi: 10.4093/kdj.2008.32.3.185
BACKGROUND: Oxidative stress contributes to vascular diseases in patients with diabetes. As the mechanism of development and progression of diabetic vascular complications is poorly understood, this study was aimed to... -
- CITED
-
- Close
- SHARE
-
- Close
- Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCdelta and p38 in Human Airway Epithelial Cells
-
Bae CH, Kim HS, Song SY, Kim YD
- KMID: 2134600
- Clin Exp Otorhinolaryngol.
- 2012 Sep;5(3):161-169.
- doi: 10.3342/ceo.2012.5.3.161
OBJECTIVES: Phorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins. MUC16, one of the membrane-bound mucins, is... -
- CITED
-
- Close
- SHARE
-
- Close
- Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cdelta and epsilon
-
Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee J, Kim C, Min SS
- KMID: 1432763
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):51-56.
- doi: 10.4196/kjpp.2013.17.1.51
Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression of NAD(P)H Oxidase Subunits and Their Contribution to Cardiovascular Damage in Aldosterone/Salt-Induced Hypertensive Rat
-
Park YM, Lim BH, Touyz RM, Park JB
- KMID: 1107531
- J Korean Med Sci.
- 2008 Dec;23(6):1039-1045.
- doi: 10.3346/jkms.2008.23.6.1039
NAD(P)H oxidase plays an important role in hypertension and its complication in aldosterone-salt rat. We questioned whether NAD(P)H oxidase subunit expression and activity are modulated by aldosterone and whether this... -
- CITED
-
- Close
- SHARE
-
- Close
- Rottlerin enhances IL-1beta-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells
-
Park EJ, Kwon TK
- KMID: 1058704
- Exp Mol Med.
- 2011 Dec;43(12):669-675.
- doi: 10.3858/emm.2011.43.12.077
Cyclooxygenase-2 (COX-2) is an important enzyme in inflammation. In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231... -
- CITED
-
- Close
- SHARE
-
- Close
- Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase
-
Byun HS, Won M, Park KA, Kim YR, Choi BL, Lee H, Hong JH, Piao L, Park J, Kim JM, Kweon GR, Kang SH, Han J, Hur GM
- KMID: 1052941
- Exp Mol Med.
- 2008 Apr;40(2):186-195.
- doi: 10.3858/emm.2008.40.2.186
Previous studies have demonstrated that rottlerin, a specific PKCdelta inhibitor, potentiates death receptor- mediated apoptosis through a cytochrome c-dependent or -independent pathway. However, its ability to regulate necrotic cell death,... -
- CITED
-
- Close
- SHARE
-
- Close
