- TT Virus Detection Using Different PCR Primer Sets in Healthy and Infected Individuals with Hepatitis B or C Viruses
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Kim HS, Kim JS, Song W, Kang HJ, Lee KM
- KMID: 2224732
- Korean J Clin Microbiol.
- 2007 Apr;10(1):14-18.
BACKGROUND: TT virus (TTV) infection is highly prevalent in the general population and in the patients infected with hepatitis B virus (HBV) or hepatitis C vius (HCV). The aim of... -
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- Structure and Expression Analyses of SVA Elements in Relation to Functional Genes
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Kwon YJ, Choi Y, Eo J, Noh YN, Gim JA, Jung YD, Lee JR, Kim HS
- KMID: 2009107
- Genomics Inform.
- 2013 Sep;11(3):142-148.
- doi: 10.5808/GI.2013.11.3.142
SINE-VNTR-Alu (SVA) elements are present in hominoid primates and are divided into 6 subfamilies (SVA-A to SVA-F) and active in the human population. Using a bioinformatic tool, 22 SVA element-associated... -
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- High Correlation between Alu Elements and the Conversion of 3' UTR of mRNAs Processed Pseudogenes
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An HJ, Na D, Lee D, Lee KH, Bhak J
- KMID: 2166170
- Genomics Inform.
- 2004 Jun;2(2):86-91.
Even though it represents 6 13% of human genomic DNA, Alu sequences are rarely found in coding regions. When in exon region, over 80 % of them are found in... -
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- Mechanisms of Myotonic Dystrophies 1 and 2
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Lubov T
- KMID: 2285303
- Korean J Physiol Pharmacol.
- 2005 Feb;9(1):1-8.
Myotonic Dystrophies type 1 and 2 (DM1/2) are neuromuscular disorders which belong to a group of genetic diseases caused by unstable CTG triplet repeat (DM1) and CCTG tetranucleotide repeat (DM2)... -
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- Complete Nucleotide Sequence of Genomic RNA of a Large-Plaque Forming Porcine Reproductive and Respiratory Syndrome Virus PL97-1/LP1
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Lee YM
- KMID: 2055039
- J Bacteriol Virol.
- 2006 Dec;36(4):293-303.
- doi: 10.4167/jbv.2006.36.4.293
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important animal pathogens in swine industry worldwide. In this study, we isolated the large-plaque forming variant virus designated... -
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- miR-526b targets 3' UTR of MMP1 mRNA
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Kim KH, Jung JY, Son ED, Shin DW, Noh M, Lee TR
- KMID: 2155432
- Exp Mol Med.
- 2015 Aug;47(8):e178.
- doi: 10.1038/emm.2015.52
Regulation of matrix metalloproteinases (MMPs) is important for many physiological processes involving cancers, inflammation, tissue remodeling and skin aging. Here, we report the novel finding that the expression of MMP1... -
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- The Role of MicroRNAs in Regulatory T Cells and in the Immune Response
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Ha TY
- KMID: 2150690
- Immune Netw.
- 2011 Feb;11(1):11-41.
- doi: 10.4110/in.2011.11.1.11
The discovery of microRNA (miRNA) is one of the major scientific breakthroughs in recent years and has revolutionized current cell biology and medical science. miRNAs are small (19~25nt) noncoding RNA... -
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- MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease
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Ha TY
- KMID: 2150701
- Immune Netw.
- 2011 Jun;11(3):135-154.
- doi: 10.4110/in.2011.11.3.135
The great discovery of microRNAs (miRNAs) has revolutionized current cell biology and medical science. miRNAs are small conserved non-coding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3'... -
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- Association between the Genetic Polymorphisms of the Biogenic Amine Transporters and the Antidepressant Responsiveness in Korean Depressed Patients
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Kim DK, Kim EJ, Lim SW, Kim H
- KMID: 2287338
- Korean J Psychopharmacol.
- 2003 Sep;14(3):274-283.
OBJECTIVE: Serotonin transporter (5-HTT) is a key synaptic regulator of serotonergic neurotransmission and a major site of action of most antidepressants. The functional polymorphism of 5-HTT gene is reported to... -
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- Prediction of Mammalian MicroRNA Targets : Comparative Genomics Approach with Longer 3' UTR Databases
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Nam S, Kim YK, Kim P, Kim VN, Shin S, Lee S
- KMID: 1572671
- Genomics Inform.
- 2005 Sep;3(3):53-62.
MicroRNAs play an important role in regulating gene expression, but their target identification is a difficult task due to their short length and imperfect complementarity. Burge and coworkers developed a... -
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- Biochemical properties of full-length hepatitis C virus RNA-dependent RNA polymerase expressed in insect cells
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Choi HB, Kim YG, Oh JW
- KMID: 1119328
- Exp Mol Med.
- 2003 Dec;35(6):475-485.
The hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B protein, is the key viral enzyme responsible for replication of the HCV viral RNA genome. Although several full-length and truncated forms... -
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- Transient Complete Atrioventricular Block in a Preterm Neonate with Congenital Myotonic Dystrophy: Case Report
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Kim HN, Cho YK, Cho JH, Yang EM, Song ES, Choi YY
- KMID: 1796955
- J Korean Med Sci.
- 2014 Jun;29(6):879-883.
- doi: 10.3346/jkms.2014.29.6.879
Congenital myotonic dystrophy (CMD) is an inherited neuromuscular disorder with cardiac rhythm abnormalities that may occur as a child grows. No report has described complete atrioventricular (AV) block detected in... -
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- Polymorphisms in the STAT-6 Gene and SLE
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Rho YH, Kim HJ, Choi SJ, Ji JD, Lee YH, Song GG
- KMID: 1585322
- J Korean Rheum Assoc.
- 2005 Mar;12(1):26-29.
OBJECTIVES: To investigate whether the new polymorphism at position 2964 (G/A) in the 3' untranslated region of the STAT-6 gene is associated with susceptibility to systemic lupus erythematosus (SLE) and... -
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- miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes
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Makki MS, Haqqi TM
- KMID: 2160620
- Exp Mol Med.
- 2015 Oct;47(10):e189.
- doi: 10.1038/emm.2015.66
IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3' untranslated region (UTR) of... -
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- Effect of Modulation of hnRNP L Levels on the Decay of bcl-2 mRNA in MCF-7 Cells
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Lim MH, Lee DH, Jung SE, Youn DY, Park CS, Lee JH
- KMID: 1457696
- Korean J Physiol Pharmacol.
- 2010 Feb;14(1):15-20.
- doi: 10.4196/kjpp.2010.14.1.15
It has been shown that CA repeats in the 3'-untranslated region (UTR) of bcl-2 mRNA contribute the constitutive decay of bcl-2 mRNA and that hnRNP L (heterogenous nuclear ribonucleoprotein L)... -
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- miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor
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Tak H, Kim J, Jayabalan , Lee H, Kang H, Cho DH, Ohn T, Nam SW, Kim W, Lee EK
- KMID: 2155388
- Exp Mol Med.
- 2014 Nov;46(11):e123.
- doi: 10.1038/emm.2014.73
Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial... -
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- Alpha-Synuclein Expression in Patients with Parkinson's Disease: A Clinician's Perspective
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Kim HJ
- KMID: 1427105
- Exp Neurobiol.
- 2013 Jun;22(2):77-83.
- doi: 10.5607/en.2013.22.2.77
Although physiological function of alpha-synuclein is not yet clearly understood, accumulating evidence strongly suggests it plays a crucial role in the pathogenesis of Parkinson disease. Pathologically, alpha-synuclein is a major... -
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- Mutational Analysis of p53, p21WAF1 and p16INK4a in Human Cervical Carcinomas
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Suh SI, Choi EJ, Baek WK, Suh MH, Cho CH, Lee TS, Cha SD
- KMID: 2146932
- J Korean Soc Microbiol.
- 1998 Aug;33(4):415-423.
Human papillomavirus (HPV) infection has been implicated to be an important causative factor for the development of cervical carcinoma. p53 gene mutation is common in human malignancies, and it is... -
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- Alterations of p15INK4B, p16INK4A and Methylthioadenosine Phosphorylase Gene in Korean Hepatdegrees Cellular Carcinoma
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Pyun HY, Cho JW, Baik WK, Park JW, Park JP, Suh MH, Suh SI
- KMID: 2175020
- J Korean Cancer Assoc.
- 2000 Jun;32(3):553-562.
PURPOSE: We analyzed the gene status of p16INK4A, p15INK4B and MTAP (methylthio adenosine phophorylase) in Korean hepatdegrees Cellular carcinoma (HCC) to investigate whether the inactivation of these genes participated in hepatdegrees Carcinogenesis,... -
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- Correlation Between Primary Tuberculous Pleurisy and NRAMP1 Genetic Polymorphism
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Kim JH, Kim BG, Jung KH, Lee SY, Park SM, Lee SH, Sin C, Cho JY, Shim JJ, In KH, Yoo SH, Kang KH
- KMID: 1877185
- Tuberc Respir Dis.
- 2000 Feb;48(2):155-165.
- doi: 10.4046/trd.2000.48.2.155
BACKGROUND: The phagolysosomal function of alveolar macrophage against M. tuberculosis infection is influenced by Nramp1, which is encoded by the NRAMP1 gene. There are several genetic polymorphisms in NRAMP1, and these polymorphisms affect... -
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