- Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells
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Wan J, Bae MA, Song BJ
- KMID: 755668
- Exp Mol Med.
- 2004 Feb;36(1):71-77.
Large doses of acetaminophen (APAP) could cause oxidative stress and tissue damage through production of reactive oxygen/nitrogen (ROS/RNS) species and quinone metabolites of APAP. Although ROS/RNS are known to modify... -
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- Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP
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Rho HW, Lee JN, Kim HR, Park BH, Park JW
- KMID: 927128
- Exp Mol Med.
- 2000 Mar;32(1):12-17.
Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian... -
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- A Case Report of Familial Benign Hypocalciuric Hypercalcemia: A Mutation in the Calcium-Sensing Receptor Gene
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Woo SI, Song H, Song KE, Kim DJ, Lee KW, Kim SJ, Chung YS
- KMID: 1110751
- Yonsei Med J.
- 2006 Apr;47(2):255-258.
- doi: 10.3349/ymj.2006.47.2.255
Familial benign hypocalciuric hypercalcemia (FBHH) is an autosomal dominant trait with high penetrance, clinically manifestating a relatively benign, lifelong, persistent hypercalcemia and hypocalciuria without hypercalcemic related complications. The calcium-sensing receptor... -
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- DNA Double Strand Breaks in Gastric Epithelium with Helicobacter pylori Infection
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Chang YJ, Byun SW, Kim HK, Cho YS, Kim SS, Kim JI, Kim JK, Jung ES
- KMID: 1387335
- Korean J Gastroenterol.
- 2012 Aug;60(2):79-85.
- doi: 10.4166/kjg.2012.60.2.79
BACKGROUND/AIMS: DNA double strand breaks (DSB) is one of the critical types of DNA damage. If unrepaired, DSB is accumulated in the nucleus of cells, the cells become apoptotic or... -
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- A Family With a Hemoglobin E Variant Including a Thai Immigrant Woman in Korea
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Jahng J, Yoon KH
- KMID: 2373618
- Ann Lab Med.
- 2017 Jan;37(1):71-73.
- doi: 10.3343/alm.2017.37.1.71
No abstract available. -
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- Disruption of Microtubules Sensitizes the DNA Damage-induced Apoptosis Through Inhibiting Nuclear Factor kappaB (NF-kappaB) DNA-binding Activity
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Lee H, Jeon J, Ryu YS, Jeong JE, Shin S, Zhang T, Kang SW, Hong JH, Hur GM
- KMID: 1779226
- J Korean Med Sci.
- 2010 Nov;25(11):1574-1581.
- doi: 10.3346/jkms.2010.25.11.1574
The massive reorganization of microtubule network involves in transcriptional regulation of several genes by controlling transcriptional factor, nuclear factor-kappa B (NF-kappaB) activity. The exact molecular mechanism by which microtubule rearrangement... -
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- Aldosterone-induced TGF-beta1 Expression is Regulated by Mitogen-Activated Protein Kinases and Activator Protein-1 in Mesangial Cells
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Han JS, Cho BS, Yang CW, Kim YS
- KMID: 1778162
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S195-S203.
- doi: 10.3346/jkms.2009.24.S1.S195
Aldosterone has been shown to stimulate renal TGF-beta1 expression. However, the mechanisms for aldosterone-induced TGF-beta1 expression have not been clearly determined in mesangial cells. We examined the role of extracellular-signal... -
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- Homozygous VN (677C to T) and d/D (2756G to A) variants in the methylenetetrahydrofolate and methionine synthase genes in a case of hyperhomocysteinemia with stroke at young age
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Song KS, Song JW, Choi JR, Kim HK, Shin JS, Kim JH
- KMID: 1085748
- Exp Mol Med.
- 2001 Jun;33(2):106-109.
Hyperhomocysteinemia is known to be associated with an increased risk of myocardial infarction, stroke, peripheral arterial disease, and venous thrombosis. Gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS)... -
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- Factors affecting transformation efficiency of BCG with a Mycobacterium-Escherichia coli shuttle vector pYUB18 by electroporation
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Cho SN, Hwang JH, Park S, Chong Y, Kim SK, Song CY, Kim JD
- KMID: 711538
- Yonsei Med J.
- 1998 Apr;39(2):141-147.
- doi: 10.3349/ymj.1998.39.2.141
BCG has been one of the vehicles for multi-recombinant vaccine. However, low transformation efficiency of BCG with plasmid DNA hampered studies involving expression of foreign antigens in BCG. In an... -
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- Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappa B activation
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Lee KY, Park JS, Jee YK, Rosen GD
- KMID: 1121100
- Exp Mol Med.
- 2002 Dec;34(6):462-468.
TNF-related apoptosis-inducing ligand (TRAIL/Apo- 2L), a newly identified member of the TNF family promotes apoptosis by binding to the transmembrane receptors (TRAIL-R1/DR4 and TRAIL-R2/ DR5). TRAIL known to activate... -
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- Detection of Aberrant p16INK4A Methylation in Sera of Patients with Liver Cirrhosis and Hepatocellular Carcinoma
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Chu HJ, Heo J, Seo SB, Kim GH, Kang DH, Song GA, Cho M, Yang US
- KMID: 1785699
- J Korean Med Sci.
- 2004 Feb;19(1):83-86.
- doi: 10.3346/jkms.2004.19.1.83
Hepatocellular carcinomas (HCCs) show genomic alterations, including DNA rearrangements associated with HBV DNA integration, loss of heterozygosity, and chromosomal amplification. The genes most frequently involved are those encoding tumor suppressors.... -
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- A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement
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Choi SI, Jang MA, Jeong WJ, Jeon BR, Lee YW, Shin HB, Hong DS, Lee YK
- KMID: 2373620
- Ann Lab Med.
- 2017 Jan;37(1):77-80.
- doi: 10.3343/alm.2017.37.1.77
No abstract available. -
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- X-linked Severe Combined Immunodeficiency Syndrome: The First Korean Case with gamma c Chain Gene Mutation and Subsequent Genetic Counseling
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Jo EK, Kumaki S, Wei D, Tsuchiya S, Kanegane H, Song CH, Noh HY, Kim YO, Kim SY, Chung HY, Kim YH, Kook H
- KMID: 1785705
- J Korean Med Sci.
- 2004 Feb;19(1):123-126.
- doi: 10.3346/jkms.2004.19.1.123
X-linked severe combined immunodeficiency (X-SCID) is a rare, life-threatening immune disorder, caused by mutations in the gamma c chain gene, which encodes an essential component of the cytokine receptors for... -
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- Glutamine on the Luminal Microbial Environment After Massive Small Bowel Resection
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Choi SH, Lee S, Lee MD
- KMID: 648787
- J Korean Med Sci.
- 2002 Dec;17(6):778-783.
- doi: 10.3346/jkms.2002.17.6.778
To evaluate the oral glutamine (GLN) on the luminal microbes and bacterial translocation (BT) in short bowel, 45 Wistar rats were utilized in three groups; A (control), and B... -
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- Association between Alcoholism and the Genetic Polymorphisms of the GABA(A) Receptor Genes on Chromosome 5q33-34 in Korean Population
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Park CS, Park SY, Lee CS, Sohn JW, Hahn GH, Kim BJ
- KMID: 1778440
- J Korean Med Sci.
- 2006 Jun;21(3):533-538.
- doi: 10.3346/jkms.2006.21.3.533
Family, twin, and adoption studies have demonstrated that genes play an important role in the development of alcoholism. We investigated the association between alcoholism and the genetic polymorphisms of the... -
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- Rapid Prenatal Diagnosis of Down Syndrome Using Quantitative Fluorescent PCR in Uncultured Amniocytes
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Lee MH, Ryu HM, Kim DJ, Lee BY, Cho EH, Yang JH, Kim MY, Han JY, Park SY
- KMID: 1786809
- J Korean Med Sci.
- 2004 Jun;19(3):341-344.
- doi: 10.3346/jkms.2004.19.3.341
Rapid prenatal diagnosis of common chromosome aneuploidies have been successful through quantitative fluoresent PCR (QF-PCR) assays and small tandem repeat (STR) markers. The purpose of our study was to investigate... -
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- A Single Nucleotide Polymorphism in the E-cadherin Gene Promoter-160 is Not Associated with Risk of Korean Gastric Cancer
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Park WS, Cho YG, Park JY, Kim CJ, Lee JH, Kim HS, Lee JW, Song YH, Park CH, Park YK, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY
- KMID: 648900
- J Korean Med Sci.
- 2003 Aug;18(4):501-504.
- doi: 10.3346/jkms.2003.18.4.501
Recently, the -160 C/A polymorphism, located within the regulatory region of E-cadherin promoter, has been shown to influence E-cadherin transcription by altering transcription factor binding. We examined the effect of... -
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