Ann Lab Med.  2017 Jan;37(1):71-73. 10.3343/alm.2017.37.1.71.

A Family With a Hemoglobin E Variant Including a Thai Immigrant Woman in Korea

Affiliations
  • 1Department of Gastroenterology, Wonkwang University Sanbon Hospital, Gunpo, Korea.
  • 2Department of Laboratory Medicine, Wonkwang University Sanbon Hospital, Gunpo, Korea. wooju67@paran.com
  • 3Institute of Wonkwang Medical Center, Iksan, Korea.

Abstract

No abstract available.


MeSH Terms

Base Sequence
DNA/metabolism
Emigration and Immigration
Female
Hemoglobin E/*genetics
Homozygote
Humans
Polymerase Chain Reaction
Republic of Korea
Sequence Analysis, DNA
Thailand
DNA
Hemoglobin E

Figure

  • Fig. 1 Sanger sequencing of the HBB gene, alkaline Hb electrophoresis (see Table 1) and peripheral blood smear (Wright stain, ×1,000) in the Hb E family. (A) Normal findings. (B) Homozygous Hb E (c.79G>A; p.Glu27Lys) variant, increased Hb F and Hb A2 fractions, and many target cells. (C) Heterozygous Hb E, increased Hb A2 and some target cells. (D) Heterozygous Hb E, increased Hb F and Hb A2, and some target cells.


Cited by  1 articles

Recent progress in laboratory diagnosis of thalassemia and hemoglobinopathy: a study by the Korean Red Blood Cell Disorder Working Party of the Korean Society of Hematology
Young Kyung Lee, Hee-Jin Kim, Kyunghoon Lee, Sang Hyuk Park, Sang Hoon Song, Moon-Woo Seong, Myungshin Kim, Jin Yeong Han
Blood Res. 2019;54(1):17-22.    doi: 10.5045/br.2019.54.1.17.


Reference

1. Kohne E. Hemoglobinopathies: clinical manifestations, diagnosis, and treatment. Dtsch Arztebl Int. 2011; 108:532–540. PMID: 21886666.
2. Weatherall DJ. Hemoglobinopathies worldwide: present and future. Curr Mol Med. 2008; 8:592–599. PMID: 18991645.
3. Fucharoen S, Winichagoon P. Thalassemia in Southeast Asia: problems and strategy for prevention and control. Southeast Asian J Trop Med Public Health. 1992; 23:647–655. PMID: 1298071.
4. Katsanis E, Luke KH, Hsu E, Yates JR. Hemoglobin E: a common hemoglobinopathy among children of Southeast Asian origin. CMAJ. 1987; 137:39–42. PMID: 3594333.
5. Park ES, Jung HL, Kim HJ, Park SS, Bae SH, Shin HY, et al. Hereditary hemolytic anemia in Korea from 2007 to 2011: A study by the Korean Hereditary Hemolytic Anemia Working Party of the Korean Society of Hematology. Blood Res. 2013; 48:211–216. PMID: 24086942.
6. Park SS, Lee YJ, Kim JY, Joo SI, Hattori Y, Ohba Y, et al. Beta-thalassemia in the Korean population. Hemoglobin. 2002; 26:135–145. PMID: 12144056.
Full Text Links
  • ALM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr