Korean J Intern Med.  2010 Dec;25(4):422-428. 10.3904/kjim.2010.25.4.422.

Association of the Superoxide Dismutase (V16A) and Catalase (C262T) Genetic Polymorphisms with the Clinical Outcome of Patients with Acute Paraquat Intoxication

• Hong JR
• Seok SJ
• Jeong DS
• Lee SG
• Gil HW
• Yang JO
• Lee EY
• Hong SY

• KMID: 964724
• DOI: http://doi.org/10.3904/kjim.2010.25.4.422

Abstract

BACKGROUND/AIMS
Many patients with acute paraquat (PQ) intoxication die even at low PQ concentrations, whereas others with similar concentrations recover. Therefore, it is possible that individual differences in antioxidant capacity are responsible for the variable clinical outcome in patients with acute PQ intoxication.
METHODS
We investigated whether there was a relationship between the genetic polymorphisms of SOD (V16A), catalase (C262T), and GPX1 (C593T) in 62 patients with acute PQ intoxication and the clinical outcomes of these patients.
RESULTS
The frequency of the Mn-SOD V/V, V/A, and A/A genotypes were 56.3, 43.5, and 0% in survivors and 86.9, 13.1, and 0% in non-survivors (p > 0.05). The GPX1 C/C, C/T, and T/T genotypes were present in 100, 0, and 0% of all subjects. The catalase C/C, C/T, and T/T genotypes were present in 100, 0, and 0% of survivors, and in 82.6, 17.4, and 0% of non-survivors. Neither erythrocyte SOD activity nor catalase activity were significantly different between survivors and non-survivors.
CONCLUSIONS
No association was found between clinical outcome of acute PQ intoxication and the genetic polymorphism of GPX1 (C593T) or the genetic polymorphisms or enzyme activity of superoxide dismutase (V16A) or catalase (C262T).

Keyword

Polymorphism, genetic; Superoxide dismutase; Catalase; Paraquat; Glutathione peroxidase GPX1

MeSH Terms

Acute Disease
Adult
Aged
Catalase/*genetics
Female
Genotype
Glutathione Peroxidase/genetics
Humans
Male
Middle Aged
Paraquat/*poisoning
Poisoning/mortality
*Polymorphism, Genetic
Superoxide Dismutase/*genetics