Korean J Intern Med.  2001 Jun;16(2):87-92.

The Effect of Cilostazol on Glucose Tolerance and Insulin Resistance in a Rat Model of Non-insulin Dependent Diabetes Mellitus

• Chang SA
• Cha BY
• Yoo SJ
• Ahn YB
• Song KH
• Han JH
• Lee JM
• Son HS
• Yoon KH
• Kang MI
• Lee KW
• Son HY
• Kang SK

Abstract

BACKGROUND: It has been reported that many peripheral vasodilating drugs might improve insulin resistance. Cilostazol, a antithrombotic agent, increases peripheral blood flow in non-insulin dependent diabetic patients. The effect of cilostazol treatment on insulin resistance in streptozotocin (STZ)-induced non-insulin dependent diabetic Wistar rats was examined. METHODS: About a half of two-day old neonate siblings were injected intraperitoneally with STZ and maintained for six months, at which time they were compared with age-matched control rats for intraperitoneal glucose tolerance test (IPGTT) and for glucose infusion rate (GINF) in a euglycemic hyperinsulinemic glucose-clamp study. After that, these studies were also performed after feeding rat chow containing cilostazol (100 mg/kg/day) to rats with STZ-induced non-insulin dependent diabetes mellitus for four-weeks and compared with those of age-matched control rats. RESULTS: In the intraperitoneal glucose tolerance test studies, plasma glucose levels of STZ-induced non-insulin dependent diabetic rats were significantly higher and plasma insulin levels significantly lower than those of age-matched control rats in the age of six months. Glucose infusion rate was lower in STZ-induced non-insulin dependent diabetic rats than those of age-matched control rats. However, after a four-week cilostazol treatment, glucose infusion rate of STZ-induced non-insulin dependent diabetic rats was not significantly different from that of control rats. CONCLUSION: These findings suggested that cilostazol may improve insulin resistance in STZ-induced non-insulin dependent diabetic rats.

Keyword

Cilostazol; Insulin resistance; Streptozotocin-induced non-insulin dependent diabetic rat; Euglycemic hyperinsulinemic clamp technique; Glucose tolerance test

MeSH Terms

Animal
Animals, Newborn
Blood Glucose/*drug effects
Comparative Study
Diabetes Mellitus, Non-Insulin-Dependent/chemically induced/*drug therapy
Disease Models, Animal
Glucose Tolerance Test
*Insulin Resistance
Male
Probability
Rats
Rats, Wistar
Reference Values
Sensitivity and Specificity
Streptozocin
Tetrazoles/*pharmacology
Vasodilator Agents/*pharmacology