Korean J Gastroenterol.
2005 May;45(5):369-373.
A Case of Hemolysis in ABO-unmatched Liver Transplantation: Use of Washed Group O Red Blood Cells and Steroids
- Affiliations
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- 1Departments of Internal Medicine, Kangnam St. Marys Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. yoonsk@catholic.ac.kr
- 2Departments of Clinical Pathology, Kangnam St. Marys Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 3Departments of General Surgery, Kangnam St. Marys Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 4Kangnam St. Marys Hospital, The Catholic University of Korea College of Medicine, WHO Collaborating Center of Viral Hepatitis, Seoul, Korea.
Abstract
- Liver transplantation is the only curative therapy for patients with end-stage liver disease. The high success rate and the increasing demand for the transplantation sometimes calls for ABO-compatible but nonidentical blood group orthotopic liver transplantation (OLT), which affords the opportunity to the production of antibody to red blood cells. Hemolytic anemia usually occurs 1 to 2 weeks after transplantation. Although mild in most patients, it can be life-threatening. Until now, a few cases showing hemolytic anemia due to donor ABO antibody formation after ABO-nonidentical OLT have been reported. In the reported cases of hemolytic anemia, most ABO-nonidentical OLT cases were O-to-A, but few reports are available on this subject with O-to-B ABO- nonidentical OLT. Herein, we report the experience with hemolysis after ABO-nonidentical OLT in a group O donor into a group B recipient and the successful treatment with transfusion of washed group O red blood cells and 60 mg dose of prednisolone for 3 days.
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