Yonsei Med J.  1981 Jun;22(1):26-32. 10.3349/ymj.1981.22.1.26.

Auto-immune Response in Degenerated Lumbar Disk

• Kim NH
• Kang ES
• Han CD
• Kim JD
• Kim CH

• KMID: 692912
• DOI: http://doi.org/10.3349/ymj.1981.22.1.26

Abstract

The serum level of Ig G, Ig M, Ig A, Ig D and C3 were determined by a Hyland Immunodiffusion plate in 60 patients and 29 normal healthy controls. Immunoglobulin G level was increased only in patient's with herniated nucleus pulposus. We also could demonstrate high levels of Ig G in group I, the ruptured nucleus cases, but there were no differences in the levels of other immunoglobulins and C3 in other groups. In the Ochterlony gel diffusion test for the detection of humoral antibody for the nucleus pulposus, only 4 cases gave precipitation lines using antigen excised from nucleus pulposus. In 2 cases high levels of Ig G were observed. All 89 patients gave negative precipitation lines using proteoglycan as antigen.

Keyword

Disk; Autoimmunity

MeSH Terms

Adolescent
Adult
Autoimmune Diseases/complications*
Back Pain/etiology
Back Pain/immunology*
Child
Female
Human
Immunoglobulins/analysis
Intervertebral Disk*
Male
Middle Age
Spinal Diseases/immunology*