J Korean Med Sci.  1994 Aug;9(4):289-298. 10.3346/jkms.1994.9.4.289.

Oncogenic osteomalacia: a clinicopathologic study of 17 bone lesions

• Park YK
• Unni KK
• Beabout JW
• Hodgson SF

• KMID: 644811
• DOI: http://doi.org/10.3346/jkms.1994.9.4.289

Abstract

Oncogenic osteomalacia is an unusual and rare clinicopathologic syndrome characterized by mesenchymal tumors that apparently produce osteomalacia and biochemical abnormalities consisting of hypophosphatemia, normocalcemia, and increased levels of alkaline phosphatase. We collected from the Mayo Clinic files and from our consultation files the records for 17 cases of osteomalacia associated with bone lesions. There were five cases of fibrous dysplasia, three of hemangiopericytoma, and two of phosphaturic mesenchymal tumor. There was one case each of osteosarcoma, chondroblastoma, chondromyxoid fibroma, malignant fibrous histiocytoma, giant cell tumor, metaphyseal fibrous defect, and hemangioma. In this study we can figure out that the most common characteristic histologic features of our cases were hemangiopericytomatous vascular proliferation, fine lace-like stromal calcification, and stromal giant cells. In most of the cases, the clinical and biochemical symptoms and signs resolved soon after complete resection of the lesion. When the lesion recurred or metastasized, the symptoms and signs also recurred.

Keyword

osteomalacia; hypophosphatemia; hemangiopericytoma; calcification; giant cells

MeSH Terms

Adolescent
Adult
Aged
Bone Neoplasms/classification/*complications/diagnosis
Child
Child, Preschool
Female
Fibrous Dysplasia of Bone/classification/*complications/diagnosis
Follow-Up Studies
Human
Male
Middle Age
Osteomalacia/*etiology/pathology