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Recalcitrant Low Back Pain Diagnosed as Hypophosphatemic Osteomalacia Induced by Antiviral Medication

Chae HJ, Won JH, Lee WK, Kim K

We report a rare case of anti-viral agent induced hypophosphatemic osteomalacia presented with localized and radicular pain. A 51-year-old man, who had been taking adefovir for chronic hepatitis, had experienced...
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Infantile hypercalcemia with novel compound heterozygous mutation in SLC34A1 encoding renal sodium-phosphate cotransporter 2a: a case report

Kang SJ, Lee R, Kim HS

Idiopathic infantile hypercalcemia is characterized by hypercalcemia, dehydration, vomiting, and failure to thrive, and it is due to mutations in 24-hydroxylase (CYP24A1). Recently, mutations in sodium-phosphate cotransporter (SLC34A1) expressed in...
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Severe Hypophosphatemia-Induced Acute Toxic-Metabolic Encephalopathy in Continuous Renal Replacement Therapy

Han SA, Park HY, Kim HW, Choi JI, Kang DY, Kim HL, Chung JH, Shin BC

Acute toxic-metabolic encephalopathy (TME) is an acute condition of global cerebral dysfunction in the absence of primary structural brain disease. Severe hypophosphatemia leads to muscle weakness and involves the diaphragm...
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Respiratory failure in a diabetic ketoacidosis patient with severe hypophosphatemia

Choi HS, Kwon A, Chae HW, Suh J, Kim DH, Kim HS

Phosphate is essential in regulating human metabolic processes, and severe hypophosphatemia can induce neurologic and hematological complications and result in respiratory failure and cardiac dysfunction. Therefore, correction of severe hypophosphatemia...
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Late and Insufficient Phosphorus Supplementation is Associated with Early Severe Hypophosphatemia in Extremely Low Birth Weight Infants with Early Amino Acid Administration

Yang SM, Noh OK, Lee JH, Park MS

OBJECTIVE: To investigate the incidence of early severe hypophosphatemia, and examine the associated clinical factors and outcomes, in extremely low birth weight infants (ELBWI) who received early amino acid administration. METHODS:...
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Successful Localization Using ⁶⁸Ga-DOTATOC PET/CT of a Phosphaturic Mesenchymal Tumor Causing Osteomalacia in a Patient with Concurrent Follicular Lymphoma

Ha S, Park S, Kim H, Go H, Lee SH, Choi JY, Hong JY, Ryu JS

Diagnosing tumor-induced osteomalacia is often challenging because conventional imaging modalities may fail to locate the responsible tumor. This report describes the ability of ⁶⁸Ga-DOTATOC PET/CT to successfully distinguish between the...
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The influence of hypophosphatemia on outcomes of low- and high-intensity continuous renal replacement therapy in critically ill patients with acute kidney injury

Kim SY, Kim YN, Shin HS, Jung Y, Rim H

BACKGROUND: The purpose of this study was to assess the role of hypophosphatemia in major clinical outcomes of patients treated with low- or high-intensity continuous renal replacement therapy (CRRT). METHODS: We...
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Oncogenic Osteomalacia with Multiple Insufficiency Fractures: A Case Report

Park YC, Seo JO, Yang KH

Oncogenic osteomalacia is a rare paraneoplastic syndrome, characterized by hypophosphatemia, renal phosphate wasting, osteomalacia, and multiple insufficiency fractures, as a result of the tumor. A wide excision of the causative...
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Dental management of patients with X-linked hypophosphatemia

Lee BN, Jung HY, Chang HS, Hwang YC, Oh WM

X-linked hypophosphatemia (XLH) is a hereditary metabolic disease caused by the loss of phosphate through the renal tubules into the urine, and an associated decrease in serum calcium and potassium...
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Severe Hypophosphatemia in a Girl with Systemic Lupus Erythematosus

Lim TJ, Kim SY, Kim SH

Systemic lupus erythematosus (SLE) is characterized by various symptoms and multi-organ involvement. Hypophosphatemia has been described in several diseases accompanied with systemic inflammation. However, hypophosphatemia has rarely been described in...
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Carpal Spasm in a Patient with Hypophosphatemia

Lee SH, Shim YJ, Choi JH, Kim HS

Phosphate is an essential ion and plays a vital role in many physiological processes. Carpopedal spasm is known as a symptom of hypocalcemia, or rarely, hypomagnesemia. We present an unusual...
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Three Cases of Osteomalacia with Fractures Induced by Adefovir in Chronic Hepatitis B

Kim AR, Choi YJ, Chung YS

Adefovir dipivoxil is used antiviral agent in the treatment of chronic hepatitis B virus infection. This drug is recommended for patients infected with lamivudine-refractory hepatitis B. Many studies of low-dose...
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Diagnostic Modalities for FGF23-Producing Tumors in Patients with Tumor-Induced Osteomalacia

Fukumoto S

Fibroblast growth factor 23 (FGF23) is a hormone that is produced by osteocytes and regulates phosphate and vitamin D metabolism through binding to the Klotho-FGF receptor complex. Excessive actions of...
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Association between Hypophosphatemia and Cardiac Arrhythmias in the Early Stage of Sepsis: Could Phosphorus Replacement Treatment Reduce the Incidence of Arrhythmias?

Schwartz A, Brotfain E, Koyfman L, Kutz R, Gruenbaum , Klein M, Zlotnik A

It is well known that new-onset arrhythmias are common in septic patients. It is thought that hypophosphatemia in the early stages of sepsis may contribute to the development of new...
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Two Cases of Hypophosphatemic Osteomalacia After Long-term Low Dose Adefovir Therapy in Chronic Hepatitis B and Literature Review

Jeong HJ, Lee JM, Lee TH, Lee JY, Kim HB, Heo MH, Choi G, Chae JN, Kim JM, Kim SH, Kwon KY

  • KMID: 2391956
  • J Bone Metab.
  • 2014 Feb;21(1):76-83.
Adefovir dipivoxil (ADV) is a nucleotide used as long-term therapy of chronic hepatitis B. Many published reports have shown that long-term high-dose therapy with adefovir can be associated with proximal...
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A FGF23-Positive Maxillary Sinus Tumor Associated with Oncogenic Osteomalacia

Kim NH, Kim JH, Kwon JH, Kim KS

  • KMID: 2297584
  • J Rhinol.
  • 2012 May;19(1):70-73.
Oncogenic osteomalacia is a rare acquired paraneoplastic syndrome caused by excessive renal phosphate wasting that causes hypophosphatemia and osteomalacia. Fibroblast growth factor 23 (FGF23) has been identified as the causative...
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Case of Thyrotoxic Periodic Paralysis Accompanied by Atrioventricular Block Associated with Hypokalemia and Hypophosphatemia

Kim HS, Wi JK, So JI, Choi MC, Chon S, Oh S, Woo JT, Kim SW, Kim JW, Kim YS

  • KMID: 2332992
  • J Korean Soc Emerg Med.
  • 2011 Oct;22(5):570-574.
Thyrotoxic periodic paralysis (TPP) occurs in 2% of the asian patients with hyperthyroidism and is characterized by bilateral flaccid paralysis of the extremity, especially lower limbs. It is well-known that...
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A Case of Osteomalacia Related to Adefovir in a Patient with Chronic Hepatitis B

Ahn SY, Ko SY, Jang YM, Choi YH, Kim BK, Choe WH, Lee CH, Kwon SY

Adefovir dipivoxil, an acyclic nucleoside analogue, has been approved for the treatment of patients with chronic hepatitis B. This agent is efficacious particularly in those who have developed lamivudine resistance....
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A case of hypophosphatemic osteomalacia associated with low-dose adefovir dipivoxil treatment

Yoo KD, Jeong JH, Cho SK, Kim GH, Choi HS, Kim DS, Jun JB

  • KMID: 2142948
  • Korean J Med.
  • 2010 Feb;78(2):261-265.
Adefovir dipivoxil (ADV) effectively inhibits lamivudine-resistant hepatitis B virus replication. Hypophosphatemia and elevated serum creatinine are ADV-related nephrotoxicity caused by high-dose ADV. Hypophosphatemic osteomalacia is very rare and is induced...
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Fluid and Electrolyte Disturbances in Critically Ill Patients

Lee JW

  • KMID: 2406197
  • Electrolyte Blood Press.
  • 2010 Dec;8(2):72-81.
Disturbances in fluid and electrolytes are among the most common clinical problems encountered in the intensive care unit (ICU). Recent studies have reported that fluid and electrolyte imbalances are associated...
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