Cognitive Impairment and Insomnia in Celiac Disease:
A Systematic Review and Meta-Analysis

Beas, Renato; Godoy, Ambar; Norwood, Dalton A.; Ascencio, Ysaith Orellana; Izquierdo-Veraza, Diego; Montalvan-Sanchez, Eleazar E.; Ramirez, Mirian; Kurada, Satya

Gut Liver. 2024 Nov;18(6):1080-1084. 10.5009/gnl240063.

Cognitive Impairment and Insomnia in Celiac Disease: A Systematic Review and Meta-Analysis

Affiliations

¹Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
²Division of Preventive Medicine, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA
³Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA
⁴Ruth Lilly Medical Library, Indiana University School of Medicine, Indianapolis, IN, USA
⁵Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA

KMID: 2561537
DOI: http://doi.org/10.5009/gnl240063

Abstract

Emerging evidence suggests a broader spectrum of celiac disease (CeD) system involvement, including neurological manifestations. We aimed to conduct a systematic review and meta-analysis of the available evidence from studies assessing the association of cognitive impairment and insomnia with CeD. A total of 259 participants with CeD were included in the studies investigating insomnia and 179 were included in studies investigating cognitive impairment. The overall pooled odds ratio for insomnia in patients with CeD was 1.83 (95% confidence interval, 1.38 to 2.42; I 2 =0.00%). The present study provides valuable insights into the available evidence from studies investigating cognitive impairment in patients with CeD and our systematic review and meta-analysis revealed a significant association between CeD and insomnia.

Keyword

Celiac disease; Insomnia; Cognitive impairment

Cognitive Impairment and Insomnia in Celiac Disease: A Systematic Review and Meta-Analysis

Abstract

Keyword

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