J Korean Acad Nurs.  2016 Feb;46(1):1-18. 10.4040/jkan.2016.46.1.1.

Correlates of Cognitive Impairment of Rheumatic Disease: Systematic Review and Meta-analysis

• Mo J
• Park J
• Oh H

• KMID: 2373158
• DOI: http://doi.org/10.4040/jkan.2016.46.1.1

Abstract

PURPOSE
This study was conducted to synthesis the results of research on relationships of cognitive impairment with multi-dimensional correlates of rheumatic disease through a systematic literature review and meta-analysis.
METHODS
For the study purpose, 23 studies were selected through a systematic process of searching the literature.
RESULTS
The study results showed that among general characteristics, age and education were the variables having a significant relationship with cognitive impairment. Among health risk factors, obesity appeared to have a significant positive relationship with cognitive impairment. For past history, diabetes and hypertension were shown to have a significant positive relationship with cognitive impairment. It was noted also that aPL, one of the physiological factor, had significant association with cognitive impairment. None of the medication related factors had a significant relationship with cognitive impairment. Results showed that among disease related factors, disease activity had the highest relationship with cognitive impairment. Depression, among psychological factors, was the only variable having a significant relationship with cognitive impairment.
CONCLUSION
The findings indicate that the variables strongly impacting on cognitive impairment in rheumatic disease are depression and disease activity.

Keyword

Cognition disorders; Rheumatic diseases; Review; Meta-analysis

MeSH Terms

Anxiety
Cognition
Cognition Disorders/complications/*pathology
Databases, Factual
Depression/complications
Humans
Hypertension/complications
Obesity/complications
Rheumatic Diseases/complications/*pathology
Risk Factors

Figure

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  Figure 1 Flow diagram for study selection.

• 

  Figure 2 Funnel plot for publication bias.

• 

  Figure 3 Forest plot of each correlates of cognitive impairment.

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