Ann Liver Transplant.  2023 May;3(1):1-5. 10.52604/alt.23.0006.

De novo gastric cancer after liver transplantation: A review of the Asian experience

• Park CS
• Chung YK

• KMID: 2560914
• DOI: http://doi.org/10.52604/alt.23.0006

Abstract

While the long-term survival outcome following liver transplantation (LT) has improved, hepatocellular carcinoma recurrence and de novo malignancy remain the major causes of patient death. Gastric cancer is one of the most frequent malignancies in Asian countries, thus this study reviewed the incidence of de novo gastric cancer following LT in Asian countries. Four Korean single-center studies revealed that de novo gastric cancer is the most common de novo malignancy after LT. The standard incidence ratio of gastric cancer in LT recipients was 1,036 per 100,000 persons in males and 318.9 per 100,000 in females. Annual or biannual endoscopic screening for gastric cancer after LT is recommended. Open gastrectomy was the standard procedure, and endoscopic resection and laparoscopic surgery were also performed. A Japanese national survey revealed that de novo gastric cancer was the third common malignancy after organ transplantation. Two Chinese studies also revealed that de novo gastric cancer was one of the common de novo malignancies after organ transplantation. In conclusion, LT recipients should be checked periodically for de novo malignancy throughout their lives, especially for cancers common in the general population. Aggressive surgical treatment contributes to the improvement of post-treatment survival outcomes.

Keyword

Stomach neoplasms; De novo malignancy; Resection; Immunosuppression therapy; Endoscopic screening