J Korean Soc Transplant.  2010 Jun;24(2):73-79. 10.4285/jkstn.2010.24.2.73.

Prophylaxis for Hepatitis B Core Antibody-Positive Donors after Liver Transplantation

• Kim HY
• Choi JY

• KMID: 1457123
• DOI: http://doi.org/10.4285/jkstn.2010.24.2.73

Abstract

The growing shortage of organs for orthotopic liver transplantation (OLT) has led to an expanded donor pool with the use of marginal grafts. Recipients who receive liver grafts from HBsAg-negative, anti-HBc positive donors have an increased risk of developing de novo hepatitis B infection. This review covers several issues in liver transplantation using hepatitis B core antibody-positive donors: (1) the mechanism of de novo hepatitis B infection, (2) high risk groups, (3) prophylactic regimens and (4) clinical significance and a proposal for patients in Korea.

Keyword

Hepatitis B core antibody positive donor; Prophylaxis; De novo hepatitis B; Liver transplantation

MeSH Terms

Hepatitis
Hepatitis B
Humans
Korea
Liver
Liver Transplantation
Tissue Donors
Transplants

Figure

• 

  Fig. 1. Risk of de novo hepatitis B infection in HBsAg-negative recipients after liver transplantation using anti-HBc positive liver graft without HBV prophylaxis in relation to pretransplant HBV serology of recipient. Abbreviations: HBsAg, hepatitis B surface antigen; anti-HBc, hepatitis B core antibody; HBV, hepatitis B virus; LT, liver transplantation. Reprinted from Fig. 1 of reference [10].

Reference

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