Immune Netw.
2024 Feb;24(1):e2. 10.4110/in.2024.24.e2.
IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials
- Affiliations
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- 1Laboratory of Immune Regulation, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea
- 2Division of Life Sciences, College of Life Science and Bioengineering, Incheon National University, Incheon 22012, Korea
- 3Research & Development Center, Cellid Co., Ltd., Seoul 08826, Korea
- 4Laboratory of Cell & Gene Therapy, Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea
- KMID: 2557916
- DOI: http://doi.org/10.4110/in.2024.24.e2
Abstract
- Studies over the last 2 decades have identified IL-17 and IL-21 as key cytokines in the modulation of a wide range of immune responses. IL-17 serves as a critical defender against bacterial and fungal pathogens, while maintaining symbiotic relationships with commensal microbiota. However, alterations in its levels can lead to chronic inflammation and autoimmunity. IL-21, on the other hand, bridges the adaptive and innate immune responses, and its imbalance is implicated in autoimmune diseases and cancer, highlighting its important role in both health and disease. Delving into the intricacies of these cytokines not only opens new avenues for understanding the immune system, but also promises innovative advances in the development of therapeutic strategies for numerous diseases. In this review, we will discuss an updated view of the immunobiology and therapeutic potential of IL-17 and IL-21.
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