J Wound Manag Res.  2024 Jun;20(2):145-153. 10.22467/jwmr.2023.02418.

Comparison between Ketogenic and Diabetic Conventional Diet on Wound Closure in Diabetic Rat Model

• Saputra MD
• Herman H
• Whitiana GD

• KMID: 2557001
• DOI: http://doi.org/10.22467/jwmr.2023.02418

Abstract

Background
Managing diabetic ulcers should be multimodal; nutrition is one of the modalities to improve wound healing. This study therefore aimed to compare ketogenic diet and conventional diabetic diet in closing the wounds of diabetic rat models.
Methods
Diabetes mellitus was induced in 30 rats which were divided equally into three groups. Group I was given a ketogenic diet (60% fat, 24% carbohydrate, and 16% protein). Group II was given a conventional diabetic diet (43% carbohydrate, 15% fat, and 42% protein). Group III was the control group with a normal diet (13% water, 18.5%–20.5% protein, fat ≥4%, fiber ≤6%, ash ≤8%, 0.9% calcium, and 0.7% phosphor). A 1 cm-diameter wound was made with the Mason-Walker model as a guideline. The rate of wound closure was measured on days 1, 7, 14, and 21 to represent each wound healing phase.
Results
On day 7, comparison between wound areas in the ketogenic diet, conventional diet, and normal diet yielded significant differences (mean, 0.664, 0.717, 0.747; P=0.051). There was also a significant difference on day 14 (mean, 0.564, 0.817, 0.647; P<0.001) and day 21 (mean, 0.164, 0.517, 0.447; P<0.001).
Conclusion
Compared to a conventional diabetic diet, a ketogenic diet significantly enhanced the wound closure rate in the diabetic rat model. Further studies are needed to confirm this finding.

Keyword

Ketogenic diet; Conventional diet; Wound healing; Diabetes mellitus; Ulcer