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Two Cases of Ketogenic Diet-Induced Prurigo Pigmentosa and a Literature Review

Yang NG, Kim JY, Eun YS, Lee SY, Chung EH, Lee HJ, Kim JE

  • KMID: 2536321
  • Korean J Dermatol.
  • 2022 Nov;60(9):601-605.
Prurigo pigmentosa (PP) is a rare inflammatory skin disease that commonly affects Asian women. It is characterized by symmetric pruritic eruptions in a reticular pattern, primarily on the back, chest,...
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Dietary Changes Leading to Euglycemic Diabetic Ketoacidosis in Sodium-Glucose Cotransporter-2 Inhibitor Users: A Challenge for Primary Care Physicians?

Somagutta MKR, Uday U, Shama N, Bathula NR, Pendyala S, Mahadevaiah A, Mahmutaj G, Ngardig NN

Background: The use of euglycemic diabetic ketoacidosis (EDKA) related to sodium-glucose cotransporter 2 inhibitors (SGLT2i) use in people with diabetes has been increasingly reported. The causes are multifactorial, and dietary...
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The Effects of Medium-Chain Triglyceride Oil Supplementation on Endurance Performance and Substrate Utilization in Healthy Populations: A Systematic Review

Chapman-Lopez TJ, Koh Y

Background: The use of medium-chain triglyceride (MCT) oil has increased due to its potential for therapeutic and ergogenic properties. Although recent evidence has suggested that MCT oil supplementation may lead...
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Efficacy of the Ketogenic Diet for Pediatric Epilepsy According to the Presence of Detectable Somatic mTOR Pathway Mutations in the Brain

Ko A, Sim NS, Choi HS, Yang D, Kim SH, Lee JS, Kim DS, Lee JH, Kim HD, Kang HC

Background and Purpose A multifactorial antiepileptic mechanism underlies the ketogenic diet (KD), and one of the proposed mechanisms of action is that the KD inhibits the mammalian target of rapamycin...
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Calorie Restriction for Cancer Prevention and Therapy: Mechanisms, Expectations, and Efficacy

Vidoni C, Ferraresi A, Esposito A, Maheshwari 1 C, Dhanasekaran DN, Mollace V, Isidoro C

Cancer is one of the most frequently diagnosed diseases, and despite the continuous efforts in searching for new and more effective treatments, its morbidity and mortality remain a significant health...
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Ketogenic Diet in Infants with Early-Onset Epileptic Encephalopathy and SCN2A Mutation

Tian X, Zhang Y, Zhang J, Lu Y, Men X, Wang X

Research has shown mutations in the voltage-gated sodium channel gene SCN2A to be associated with developmental delays and infantile seizures in patients with early-onset epileptic encephalopathies (EOEEs). Here, we report...
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The Early Response to Dietary Therapy can Predict the Late Outcome in Children with Intractable Epilepsy

Lim Sy, Yum MS, Ahn H, Kim MJ, Jang HN, Ko TS

Background and Purpose Dietary therapy (DT), including the ketogenic diet (KD), is one of the nonpharmacological treatment options for patient with drug-resistant epilepsy. However, maintaining DT in patients without seizure...
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Clinical and Genetic Spectrum of ATP1A3-Related Disorders in a Korean Pediatric Population

Kim WJ, Shim YK, Choi SA, Kim SY, Kim H, Hwang H, Choi J, Kim KJ, Chae JH, Lim BC

BACKGROUND AND PURPOSE: The aim of this study was to expand the understanding of the genotype-phenotype spectrum of ATP1A3-related disorders and to evaluate the therapeutic effect of a ketogenic diet...
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Diagnostic Challenges Associated with GLUT1 Deficiency: Phenotypic Variabilities and Evolving Clinical Features

Kim H, Lee JS, Lee Y, Kim SY, Lim BC, Kim KJ, Choi M, Chae JH

GLUT1 deficiency is a rare neurometabolic disorder that can be effectively treated with ketogenic diet. However, this condition is underdiagnosed due to its nonspecific, overlapping, and evolving symptoms with age....
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Acute Tubular Necrosis associated with the Ketogenic Diet in a Child with Intractable Epilepsy

Yoo KH, Yim HE

The ketogenic diet (KD) has been used as an effective antiepileptic therapy for intractable childhood epilepsy. However, various adverse effects have been reported with use of the KD. We report...
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Rationale, Feasibility and Acceptability of Ketogenic Diet for Cancer Treatment

Chung HY, Park YK

Ketogenic diet has been used for more than 80 years as a successful dietary regimen for epilepsy. Recently, dietary modulation by carbohydrate depletion via ketogenic diet has been suggested as...
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Protein-Losing Enteropathy as a Complication of the Ketogenic Diet

Ahn WK, Park S, Kim HD

The ketogenic diet is an effective treatment for the patients with intractable epilepsy, however, the diet therapy can sometimes be discontinued by complications. Protein–losing enteropathy is a rarely reported serious...
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Ketogenic Diet for Children with Epilepsy: A Practical Meal Plan in a Hospital

Lee E, Kang HC, Kim HD

A ketogenic diet (KD) is a dietary approach to treat intractable epilepsy. The KD begins with hospitalization and the child and their parents can adapt to the KD for 1-2...
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Efficacy of and Patient Compliance with a Ketogenic Diet in Adults with Intractable Epilepsy: A Meta-Analysis

Ye F, Li XJ, Jiang WL, Sun HB, Liu J

BACKGROUND AND PURPOSE: Despite the successful use of a ketogenic diet in pediatric epilepsy, its application in adults has been limited. The aim of this meta-analysis was to summarize the...
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Lower fat and better quality diet therapy for children with pharmacoresistant epilepsy

Yoon JR, Kim HD, Kang HC

The ketogenic diet (KD) is an established, effective, nonpharmacologic treatment for children with pharmacoresistant epilepsy. Although the KD is the most well-established dietary therapy for epilepsy, it is too restrictive...
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The use of ketogenic diet in special situations: expanding use in intractable epilepsy and other neurologic disorders

Lee M

The ketogenic diet has been widely used and proved to be effective for intractable epilepsy. Although the mechanisms underlying its anti-epileptic effects remain to be proven, there are increasing experimental...
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Effect of beta-Hydroxybutyrate on Flurothyl-Induced Seizure Susceptibility

Shin CG, Kim DW

  • KMID: 2176827
  • J Korean Child Neurol Soc.
  • 2010 Nov;18(2):225-229.
PURPOSE: The ketogenic diet (KD) remains a therapy in search of explanation although it is an established treatment for patients with intractable seizures. It was designed to mimic the biochemical...
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The Ketogenic Diet Suppresses the Cathepsin E Expression Induced by Kainic Acid in the Rat Brain

Jeong HJ, Kim H, Kim YK, Park SK, Kang DW, Yoon D

PURPOSE: The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, we analyzed the changes in gene...
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Renal Stone Associated with the Ketogenic Diet in a 5-Year Old Girl with Intractable Epilepsy

Choi JN, Song JE, Shin JI, Kim HD, Kim MJ, Lee JS

In this paper, we report on a 5-year-old girl who developed a renal stone while following the ketogenic diet to treat refractory seizure disorder. Three months after initiating the ketogenic...
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Adverse Effects of Ketogenic Diet and its Recovery in Rats

Park HD, Kim DW, Kang SH, Kim JM

  • KMID: 2063591
  • J Korean Epilepsy Soc.
  • 2007 Dec;11(2):97-105.
BACKGROUND & OBJECTIVES: We tried to investigate the impact of prolonged KD on liver, and their recovery in rats. METHOD: KD was administered to 25 male Sprague-Dawley rats, while 25 control...
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