Dement Neurocogn Disord.
2024 Apr;23(2):89-94. 10.12779/dnd.2024.23.2.89.
Ventral Anterior Cingulate Atrophy as a Predisposing Factor for Transient Global Amnesia
- Affiliations
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- 1Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea
- 2Department of Neurology, Seoul National University College of Medicine, Seoul, Korea
- 3Department of Neurology, National Medical Center, Seoul, Korea
- 4Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea
- 5Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Korea
- 6Department of Neurology, Wonkwang University School of Medicine and Regional Cardiocerebrovascular Center, Iksan, Korea
- 7Department of Neurology, Veterans Health Service Medical Center, Seoul, Korea
- 8Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea
- 9Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
- KMID: 2555746
- DOI: http://doi.org/10.12779/dnd.2024.23.2.89
Abstract
- Background and Purpose
This study aimed to evaluate the brain magnetic resonance imaging (MRI) of patients with acute transient global amnesia (TGA) using volumetric analysis to verify whether the brains of TGA patients have pre-existing structural abnormalities.
Methods
We evaluated the brain MRI data from 87 TGA patients and 20 age- and sexmatched control subjects. We included brain MRIs obtained from TGA patients within 72 hours of symptom onset to verify the pre-existence of structural change. For voxel-based morphometric analyses, statistical parametric mapping was employed to analyze the structural differences between patients with TGA and control subjects.
Results
TGA patients exhibited significant volume reductions in the bilateral ventral anterior cingulate cortices (corrected p<0.05).
Conclusions
TGA patients might have pre-existing structural changes in bilateral ventral anterior cingulate cortices prior to TGA attacks.
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