Tissue Eng Regen Med.
2023 Oct;20(6):793-809. 10.1007/s13770-023-00557-6.
Using Pre-Clinical Studies to Explore the Potential Clinical Uses of Exosomes Secreted from Induced Pluripotent Stem CellDerived Mesenchymal Stem cells
- Affiliations
-
- 1Addenbrookes Major Trauma Unit, Department of Trauma And Orthopaedics, Cambridge University Hospitals, Cambridge, UK
- 2School Of Clinical Medicine, University Of Cambridge, Cambridge, UK
- 3Department of Life Science, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK
- 4Beijing Rehabilitation Hospital Affiliated to National Research Centre for Rehabilitation Technical Aids, Ministry of Civil Affairs of China, Beijing, China
- 5Watford General Hospital, London, UK
- 6Weifang People’s Hospital, Weifang City, Shandong Province, China
- KMID: 2546834
- DOI: http://doi.org/10.1007/s13770-023-00557-6
Abstract
- Recent studies of exosomes derived from mesenchymal stem cells (MSCs) have indicated high potential clinical applications in many diseases. However, the limited source of MSCs impedes their clinical research and application. Most recently, induced pluripotent stem cells (iPSCs) have become a promising source of MSCs. Exosome therapy based on iPSC-derived MSCs (iMSCs) is a novel technique with much of its therapeutic potential untapped. Compared to MSCs, iMSCs have proved superior in cell proliferation, immunomodulation, generation of exosomes capable of controlling the microenvironment, and bioactive paracrine factor secretion, while also theoretically eliminating the dependence on immunosuppression drugs. The therapeutic effects of iMSC-derived exosomes are explored in many diseases and are best studied in wound healing, cardiovascular disease, and musculoskeletal pathology. It is pertinent clinicians have a strong understanding of stem cell therapy and the latest advances that will eventually translate into clinical practice. In this review, we discuss the various applications of exosomes derived from iMSCs in clinical medicine.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Adipose Tissue - Adequate, Accessible Regenerative Material
- Mesenchymal Stem Cell and MicroRNA Therapy of Musculoskeletal Diseases
- Clinical Applications of Neural Stem Cells for the Treatment of Peripheral Neuropathy
- Mesenchymal Stem Cell Therapy in Pulmonary Disease
- Stem Cell Properties of Therapeutic Potential
