Gut Liver.
2023 Sep;17(5):731-740. 10.5009/gnl220254.
The Clinicopathological Features of Mixed Carcinoma in 7,215 Patients with Gastric Cancer in a Tertiary Hospital in South Korea
- Jo HH
1,2 - Kim N1,3
- Oh HJ4
- Song DH1
- Choi Y1
- Park J1
- Lee J1
- Yoon H1
- Shin CM1
- Park YS1
- Lee DH1,3
- Lee HS5
- Park YS6
- Ahn SH6
- Suh YS6
- Park DJ6,7
- Kim HH6,7
- Kim JW1
- Kim JW1
- Lee KW1,3
- Chang W8
- Park JH8
- Lee YJ8
- Lee KH8,9
- Kim YH8,9
- Ahn S10
- Affiliations
-
- 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
- 2Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea
- 3Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
- 4Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea
- 5Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
- 6Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea
- 7Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
- 8Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea
- 9Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
- 10Division of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Korea
- KMID: 2546015
- DOI: http://doi.org/10.5009/gnl220254
Abstract
- Background/Aims
There are few reports regarding mixed carcinoma, defined as a mixture of glandular and poorly cohesive components, in patients with gastric cancer (GC). The aim of this study was to evaluate the proportion and characteristics of mixed carcinoma in GC patients.
Methods
A total of 7,215 patients diagnosed with GC at Seoul National University Bundang Hospital were enrolled from March 2011 to February 2020. GC was divided into four groups (wellmoderately differentiated GC, poorly differentiated GC, poorly cohesive carcinoma, and mixed carcinoma). The proportion of each GC type and the clinicopathological features were analyzed and divided into early GC and advanced GC.
Results
The proportion of mixed carcinoma was 10.9% (n=787). In early GC, submucosal invasion was the most common in poorly differentiated (53.7%), and mixed carcinoma ranked second (41.1%). Mixed carcinoma showed the highest proportion of lymph node metastasis in early GC (23.0%) and advanced GC (78.3%). In advanced GC, the rate of distant metastasis was 3.6% and 3.9% in well-moderately differentiated GC and mixed carcinoma, respectively, lower than that in poorly differentiated GC (6.4%) and poorly cohesive carcinoma (5.7%), without statistical significance.
Conclusions
Mixed carcinoma was associated with lymph node metastasis compared to other histological GC subtypes. And it showed relatively common submucosal invasion in early GC, but the rates of venous invasion and distant metastasis were lower in advanced GC. Further research is needed to uncover the mechanism underlying these characteristics of mixed carcinoma (Trial registration number: NCT04973631).
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