J Yeungnam Med Sci.  2023 Apr;40(2):115-122. 10.12701/jyms.2022.00017.

Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review

• Choi EK
• Lim DG

• KMID: 2541937
• DOI: http://doi.org/10.12701/jyms.2022.00017

Abstract

Hepatic ischemia-reperfusion injury is a major complication of liver transplantation, trauma, and shock. This pathological condition can lead to graft dysfunction and rejection in the field of liver transplantation and clinical hepatic dysfunction with increased mortality. Although the pathological mechanisms of hepatic ischemia-reperfusion injury are very complex, and several intermediators and cells are involved in this phenomenon, oxidative stress and inflammatory responses are the key processes that aggravate hepatic injury. This review summarizes the current understanding of oxidative stress and inflammatory responses and, in that respect, addresses the therapeutic approaches to attenuate hepatic ischemia-reperfusion injury.

Keyword

Inflammation; Ischemia; Liver; Oxidative stress; Reperfusion injury

Figure

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  Fig. 1. Pathologic cascade contributing to ischemia and reperfusion injury. Adapted from Kalogeris et al. [2] with permission of Elsevier. ATP, adenosine 5′-triphosphate; ROS, reactive oxygen species; MPT, mitochondrial permeability transition.

Reference

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