Korean J Psychosom Med.  2022 Dec;30(2):112-118. 10.22722/KJPM.2022.30.2.112.

Risk Factors for Zolpidem Induced Sleep-Related Behavior in Inpatients

• Kim HI
• Lee JS
• Kim WH
• Kim HY
• Maeng Sr
• Bae JN

• KMID: 2538672
• DOI: http://doi.org/10.22722/KJPM.2022.30.2.112

Abstract

Objectives
：Zolpidem is a common drug used in insomnia. However, there are several reports of side effects of the central nervous system or sleep related behavior in patients who took zolpidem. This study was conducted to investigate risk factors affecting sleep related behavior after taking zolpidem in inpatients.
Methods
：From January 1, 2019 to December 31, 2019, medical records of patients who took zolpidem hospitalized at Inha University Hospital were reviewed retrospectively.
Results
：907 patients who took Zolpidem, 102 (11.2%) showed sleep related behavior, and if they were 65years of age or older, men, taking antipsychotics, and taking antipsychotics and benzodiazepines at the same time, they were significantly more likely to show sleep related behavior.
Conclusions
：Risk factors for sleep-related behavior after use of zolpidem are estimated gender, elderly, antipsychotics, and combination of antipsychotics and benzodiazepines.

Keyword

Zolpidem; Insomnia; Sleep related behavior; Antipsychotics; Benzodiazepine