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Zolpidem-Induced Complex Sleep-Related Behavior

Lee J, Chang SM

  • KMID: 2517217
  • J Korean Soc Biol Ther Psychiatry.
  • 2021 Jun;27(2):89-96.
Zolpidem is a non-benzodiazepine hypnotic agent as an agonist of the GABA A benzodiazepine receptor. Zolpidem is considered to have lower abuse and dependence potential than benzodiazepines, and is widely...
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‘Z-trip’? A Comprehensive Overview and a Case-series of Zolpidem Misuse

Orsolini L, Chiappini S, Grandinetti P, Bruschi A, Testa R, Provenzano A, Berardis DD, Volpe U

Although believed safer compared to short-acting benzodiazepines (BZD), in the past few years a growing concern has developed relating to the abuse of Z-drugs, and specifically of zolpidem. Here we...
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Paradoxical Motor and Cognitive Function Recovery in Response to Zolpidem in a Patient with Hypoxic-ischemic Brain Injury: A Case Report

Hahm MH, Woo J

We report an extremely rare case of a patient with hypoxic-ischemic brain injury who recovered consciousness and motor and cognitive functions due to paradoxical response after zolpidem administration. A 32-year-old...
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Effects of zolpidem on sleep parameters in patients with cirrhosis and sleep disturbances: A randomized, placebo-controlled trial

Sharma MK, Kainth S, Kumar S, Bhardwaj A, Agarwal HK, Maiwall R, Jamwal KD, Shasthry S, Jindal A, Choudhary , Anand L, Dhamija RM, Kumar G, Sharma BC, Sarin SK

BACKGROUND/AIMS: The aim of this study was to study the efficacy and safety of zolpidem for sleep disturbances in patients with cirrhosis. METHODS: Fifty-two Child-Turcotte-Pugh (CTP) class A or B cirrhotics...
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Comorbid Zolpidem Dependence and Over-the-Counter Compound Analgesic Abuse

Kim H, Shin C, Ko YH, Han C

Zolpidem is a commonly prescribed hypnotic used to treat insomnia. However, its potential for abuse and dependence has recently become controversial. Although over-the-counter (OTC) medications are widely used, their abuse...
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Development of Safety Usage Guidelines for Sedative Hypnotics Using the Delphi Technique

Nam YJ, Cho CH, Lee Y, Lee HJ

OBJECTIVES: The objective of this study was to develop evidence- and consensus-based clinical safety usage guidelines for sedative hypnotics using the Delphi technique. METHODS: A group of 15 sleep experts from...
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Zolpidem Detection and Blood Level in Acute Poisoning-suspected Patients in Emergency Departments: Review of 229 Cases

Yu J, Chang H, Won S, Yeom J, Lee A, Park NY, Oh BJ

PURPOSE: Non-benzodiazepine hypnotic drugs (including zolpidem) are associated with an increased risk of suicide and suicidal ideation. Considering the wide usage of zolpidem, this drug should be considered a possible...
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Transient Global Amnesia Developed after Zolpidem Intake

Kim JH, Hwang Y, Kim BS, Kim JS

We report two patients who complained of transient anterograde amnesia and repetitive questioning, that developed after taking zolpidem and lasted for several hours. The clinical manifestations of these patients fulfill...
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Zolpidem Induced Sleep-related Eating and Complex Behaviors in a Patient with Obstructive Sleep Apnea and Restless Legs Syndrome

Park YM, Shin HW

Zolpidem-induced sleep-related complex behaviors (SRCB) with anterograde amnesia have been reported. We describe herein a case in which the development of zolpidem-induced sleep-related eating disorder (SRED) and SRCB was strongly...
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Acute Kidney Injury due to Rbadomyolysis Complicated with Zolpidem Overdose

Kim HI, Jo SH, Hong HL, Lee IH, Ahn KS, Kang GW

Zolpidem (Stilnox®, Handok, Seoul, Korea) is a hypnotic imidazopyridine that is often used to treat insomnia because it has less abuse and addiction potential than benzodiazepines. Its side effects include...
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Zolpidem-Induced Arousal by Paradoxical GABAergic Stimulation: A Case Report With F-18 Flumazenil Positron Emission Tomography and Single Photon Emission Computed Tomography Study

Kim C, Kwon BS, Nam KY, Park JW, Lee HJ

Zolpidem is a non-benzodiazepine drug that has selectivity for the gamma-aminobutyric acid (GABA) receptors. We experienced paradoxical effect of zolpidem in a 48-year-old male patient with hypoxic-ischemic brain injury after...
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Multimodal Hallucination (Audio-visual, Kinaesthetic and Scenic) Associated with the Use of Zolpidem

Ram D, Eiman N, Gowdappa B

We are reporting a case of zolpidem induced multimodal hallucinations in a 22 year old female without any history of psychiatric disorders. Zolpidem, by acting on gamma-amino butyric acid type...
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Effect of a Sleep Aid in Analgesia after Arthroscopic Rotator Cuff Repair

Cho CH, Lee SW, Lee YK, Shin HK, Hwang I

PURPOSE: The aim of this study was to evaluate the effects and safety of a sleep aid for postoperative analgesia in patients undergoing arthroscopic rotator cuff repair. MATERIALS AND METHODS: Seventy-eight...
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The Effects of Zolpidem on Akinesia in a Parkinson Disease Patient: A Case Report

Kim MJ

Zolpidem, an imidazopyridine drug that affects the gamma-aminobutyric acid receptor, is typically used as a hypnotic sedative. It has been reported that this drug improves motor symptoms in patients with...
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Incidence of and Risk Ractors for Zolpidem-Induced Delirium

Kim YM, Lee S, Jung JY, Shin KH, Kim DH, Kim JH, Jee YK

  • KMID: 2142894
  • Korean J Med.
  • 2013 Jun;84(6):804-809.
BACKGROUND/AIMS: Zolpidem is a safe and effective drug for the treatment of insomnia. However, there are some reports of adverse effects, such as delirium, after administration of zolpidem. The aim...
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Zolpidem, Is it a Safe Drug for Insomnia Management?

Park KH, Lee JH

  • KMID: 2142893
  • Korean J Med.
  • 2013 Jun;84(6):802-803.
Zolpidem is one of commonly prescribed hypnotics in worldwide. Zolpidem is more favored than benzodiazepines because of its efficacy and safety profiles. However there were many reports those concerns about...
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A Case of Seizures after Zolpidem Withdrawal

Moon HJ, Lee JW, Yoo BD

  • KMID: 2203678
  • J Korean Soc Clin Toxicol.
  • 2013 Dec;11(2):127-129.
The imidazopyridine, zolpidem, a non-benzodiazepine hypnotic drug, is widely-prescribed for insomnia. It is regarded as a good alternative to benzodiazepine because of the reduced possibility for abuse and development of...
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Zolpidem Use and Risk of Fracture in Elderly Insomnia Patients

Kang DY, Park S, Rhee CW, Kim YJ, Choi NK, Lee J, Park BJ

OBJECTIVES: To evaluate the risk of fractures related with zolpidem in elderly insomnia patients. METHODS: Health claims data on the entire South Korean elderly population from January 2005 to June 2006...
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High-Dose Zolpidem Dependence and Detoxification from Withdrawal Symptoms Using Diazepam

Rhee SJ, Ko SM, Choi JW, Park H

Zolpidem is a nonbenzodiazepine hypnotic for the treatment of insomnia, and known as a relatively-safe medication. However, there have been several case reports of zolpidem abuse aand dependence these days....
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Sleep-Related Eating Disorder

Park YM

  • KMID: 2317498
  • Sleep Med Psychophysiol.
  • 2011 Jun;18(1):5-9.
Sleep-related eating disorder (SRED) is a newly recognized parasomnia that describes a clinical condition of compulsive eating under an altered level of consciousness during sleep. Recently, it is increasingly recognized...
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