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Benzodiazepine Use and Long-Term Mortality in South Korean Adult Population: A Cohort Study

Oh TK, Park HY, Song IA

Purpose: Studies have reported mixed results on the association between benzodiazepine use and mortality. Here, we investigated whether benzodiazepine use is associated with a higher risk of 5-year all-cause mortality,...
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Assessment and Treatment of Alcohol Withdrawal Syndrome

Choi HY, Seo JS, Lee SK

Alcohol withdrawal syndrome (AWS) is the most common and well-known condition occurring after intentional or unintentionalcessation or decreasing heavy drinking. Approximately 5-10% of these people are suffering from serious medical...
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Benzodiazepine-Related Cognitive Impairment or Dementia: A Signal Detection Study Using a Case/Non-Case Approach

Baek YH, Kim HJ, Bae JH, Lee H, Oh IS, Kim WJ, Shin JY

Objective The association between benzodiazepine use and the risk of cognitive impairment or dementia has been controversial. Our study aims to detect this association through a case/non-case method using the...
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A Durable Minimal Intervention Strategy to Reduce Benzodiazepine Use in a Primary Care Population

Davidson S, Thomson C, Prescott G

Background: Benzodiazepines are commonly prescribed drugs with approximately 10% of adults having used them in the past year. These drugs are clearly addictive, yet many patients are prescribed these for...
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Midazolam use in pediatric dentistry: a review

Jain SA, Rathi N, Thosar N, Baliga S

Behaviour management and dental procedures performed in very young, pre-cooperative, highly anxious, or medically disabled children are challenging tasks. Various drugs and methods have, however, been introduced to facilitate treatment...
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Development of Safety Usage Guidelines for Sedative Hypnotics Using the Delphi Technique

Nam YJ, Cho CH, Lee Y, Lee HJ

OBJECTIVES: The objective of this study was to develop evidence- and consensus-based clinical safety usage guidelines for sedative hypnotics using the Delphi technique. METHODS: A group of 15 sleep experts from...
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Risk of Dementia in Long-Term Benzodiazepine Users: Evidence from a Meta-Analysis of Observational Studies

He Q, Chen X, Wu T, Li L, Fei X

BACKGROUND AND PURPOSE: There is conflicting evidence in the literature on the association between benzodiazepines (BDZs) and the risk of dementia. This meta-analysis aimed to determine the relationship between the...
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Benzodiazepine-Associated Carcinogenesis: Focus on Lorazepam-Associated Cancer Biomarker Changes in Overweight Individuals

Ku SC, Ho PS, Tseng YT, Yeh TC, Cheng SL, Liang CS

OBJECTIVE: Cellular, animal, and human epidemiological studies suggested that benzodiazepines increase the risk of cancer and cancer mortality. Obesity is also clearly linked to carcinogenesis. However, no human studies have...
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Assessment of Switching to Suvorexant versus the Use of Add-on Suvorexant in Combination with Benzodiazepine Receptor Agonists in Insomnia Patients: A Retrospective Study

Hatano M, Kamei H, Inagaki R, Matsuzaki , Hanya M, Yamada S, Iwata N

OBJECTIVE: Suvorexant is a novel hypnotic drug that does not interact with the conventional γ-aminobutyric acid (GABA)-A receptor. We investigated the method by which suvorexant was introduced in insomnia patients...
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The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia

Pyeon T, Chung S, Kim I, Lee S, Jeong S

BACKGROUND: Benzodiazepines have been used preoperatively as part of an anesthesia regimen to attenuate the anxiety of patients. In this study, we aimed to examine the effect of oral triazolam,...
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Demographic Characteristics, Medication Profile and Treatment Outcome of Patients with Very Early-Onset Schizophrenia in One Hospital

Choi S, Cho HK, Lee MK

OBJECTIVES: Very early-onset schizophrenia (VEOS) is a type of psychosis having a low frequency, insidious onset, and devastating clinical outcome. In this study, the demographic features, information on medication, clinical...
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Benzodiazepine Use among Patients with Schizophrenia in Korea: Analysis of Database of Health Insurance Review Agency

Choi S, Lee SU, Hwang TY

OBJECTIVE: This study was designed to examine the pattern of benzodiazepine use in a representative sample of patients with schizophrenia in Korea. METHOD: Data generated by the Health Insurance Review Agency...
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Risk Factors for Aspiration Pneumonia in Acute Benzodiazepine Overdose

Chung WS, Cha KM, Kim HM, Jeong WJ, So BH

  • KMID: 2328236
  • J Korean Soc Clin Toxicol.
  • 2016 Jun;14(1):26-32.
PURPOSE: Aspiration pneumonia is an important complication of drug intoxication with decreased mental status. The purpose of the study is to investigate the risk factors of aspiration pneumonia in the...
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Flumazenil administration in suspected patients with acute hypnotics and sedatives poisoning: risk-benefit re-evaluation

Huh JH, Choi SC, Lim YG, Lampotang , Park EJ

PURPOSE: The use of flumazenil administration in the emergency department is still controversial because of concerns about adverse effects. The present study was conducted to re-evaluate the risk-benefit ratio associated...
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Clinical Analysis of Flumazenil Administration in the Single Emergency Department for Unconscious Patients, Suspected Benzodiazepine Overdose

Kim HJ, Kim YH, Lee JH, Hwang SY, Cho KW, Kang MJ, Lee DW, Lee KY, Lee NK

PURPOSE: Flumazenil is an effective benzodiazepine antagonist. However, serious adverse effects, including seizures, cardiac arrhythmias, and even death, have been reported in patients treated with flumazenil. These adverse effects are...
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Considerations for submucosal midazolam administration in combination with oral and inhaled medications for sedation of pediatric dental patients

Baek K

  • KMID: 2310710
  • J Dent Anesth Pain Med.
  • 2015 Jun;15(2):47-52.
Sedation allows patients to maintain their airway independently and respond appropriately to physical stimulation and verbal command while maintaining a minimum depressed level of consciousness. Drugs commonly used for sedation...
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Quantitative EEG Characteristics of Periodic Lateralized Epileptiform Discharges according to Benzodiazepine Responsiveness

Kim YS, Jung KY, Kim JM, Kim D

BACKGROUND: Periodic lateralized epileptiform discharges (PLEDs) are associated with altered consciousness in 75% of patients. Major controversy about PLEDs is whether they are ictal or interictal phenomenon. Diagnosis of non-convulsive...
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A Case of Pulmonary Thromboembolism Complicating Acute Overdose of Benzodiazepines

Choi JY, Jeong J

  • KMID: 2333825
  • J Korean Soc Emerg Med.
  • 2014 Apr;25(2):199-201.
Acute pulmonary thromboembolism (PTE) is a major medical problem in many hospitalized patients with medical and surgical conditions, and venous thromboembolism is responsible for up to 15% of all in-hospital...
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Incidence and Risk Factors of Intraoperative Floppy Iris Syndrome During Cataract Surgery

Park HG, Choi S

  • KMID: 2338593
  • J Korean Ophthalmol Soc.
  • 2014 Jan;55(1):73-78.
PURPOSE: To determine the incidence and risk factors of intraoperative floppy iris syndrome (IFIS) in patients undergoing cataract surgery. METHODS: The present study included 981 eyes of 655 patients who underwent...
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Incidence of and Risk Ractors for Zolpidem-Induced Delirium

Kim YM, Lee S, Jung JY, Shin KH, Kim DH, Kim JH, Jee YK

  • KMID: 2142894
  • Korean J Med.
  • 2013 Jun;84(6):804-809.
BACKGROUND/AIMS: Zolpidem is a safe and effective drug for the treatment of insomnia. However, there are some reports of adverse effects, such as delirium, after administration of zolpidem. The aim...
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