Int J Oral Biol.
2022 Dec;47(4):55-62. 10.11620/IJOB.2022.47.4.55.
Naringin enhances the migration and osteogenic differentiation of human dental pulp stem cells
- Affiliations
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- 1Department of Oral Physiology, Pusan National University, Yangsan 50612, Republic of Korea
- 2Periodontal Disease Signaling Network Research Center (MRC), Pusan National University, Yangsan 50612, Republic of Korea
- 3Dental and Life Science Institute, Pusan National University, Yangsan 50612, Republic of Korea
- 4Department of Orthodontics, Pusan National University, Yangsan 50612, Republic of Korea
- 5Department of Dental Pharmacology, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea
- KMID: 2538495
- DOI: http://doi.org/10.11620/IJOB.2022.47.4.55
Abstract
- Bioactive flavonoids have been shown to improve the biological activity of stem cells derived from different sources in tissue regeneration. The goal of this study was to see how naringin, a natural flavonoid discovered in citrus fruits, affected the biological properties of human dental pulp stem cells (HDPSCs). In this study, we found that naringin increases the migratory ability of HDPSCs. Naringin increased matrix metalloproteinase-2 (MMP-2) and C-X-C chemokine receptor type 4 (CXCR4) mRNA and protein expression in HDPSCs. ARP100, a selective MMP-2 inhibitor, and AMD3100, a CXCR4 antagonist, both inhibited the naringin-induced migration of HDPSCs. Furthermore, naringin increased osteogenic differentiation of HDPSCs and the expression of the osteogenic-related marker, alkaline phosphatase in HDPSCs. Taken together, our findings suggest that naringin may be beneficial on dental tissue or bone regeneration by increasing the biological activities of HDPSCs.
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