J Korean Assoc Oral Maxillofac Surg.  2022 Oct;48(5):259-266. 10.5125/jkaoms.2022.48.5.259.

Associations between obstructive sleep apnea and painful temporomandibular disorder: a systematic review

Affiliations
  • 1Clinic of Oral Medicine and Orofacial Pain, Ajou University School of Medicine, Suwon, Korea
  • 2Department of Oral and Maxillofacial Surgery, Institute of Oral Health Science, Ajou University School of Medicine, Suwon, Korea

Abstract

The relationship between obstructive sleep apnea (OSA) and diverse types of pain conditions have been proposed. However, no consensus on the relationship between OSA and painful temporomandibular disorders (TMDs) has been established. Therefore, this systematic review has been conducted to review the existing literatures and provide comprehensive synthesis of such literatures about OSA and painful TMDs using the evidence-based methodology. A literature search was conducted using two electronic databases, Scopus, and PubMed. Risk of bias was assessed using the risk-ofbias assessment tool for non-randomized study version 2.0. A total of 158 articles were screened from the initial search and eventually, 5 articles were included in this systematic review. One study adopted both the longitudinal prospective cohort and case-control designs and other 4 articles adopted the cross-sectional design. Two studies employed polysomnography (PSG) for the diagnosis of OSA and mentioned the results from the PSG. All crosssectional studies demonstrated higher OSA prevalence among patients with TMD, and one cohort study suggested OSA as a risk factor for TMD. OSA appears to have potential influences on the development of TMD; however, the role of TMD in the development of OSA remains to be unknown owing to the lack of high-quality evidences.

Keyword

Obstructive sleep apnea; Temporomandibular disorder; Pain; Inflammation; Sleep fragmentation

Figure

  • Fig. 1 The PRISMA (Preferred Reporting Items for Systemic Review and Meta-Analysis) flow chart.

  • Fig. 2 RoBANS (risk-of-bias assessment tool for non-randomized study) graph.

  • Fig. 3 RoBANS (risk-of-bias assessment tool for non-randomized study) summary. Green: low risk of bias, Yellow: unclear risk of bias, Red: high risk of bias.


Reference

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