Cancer Res Treat.  2022 Oct;54(4):1130-1137. 10.4143/crt.2021.1103.

Real-World Evidence of Trastuzumab, Pertuzumab, and Docetaxel Combination as a First-Line Treatment for Korean Patients with HER2-Positive Metastatic Breast Cancer

• Lee YP
• Lee MS
• Kim H
• Kim JY
• Ahn JS
• Im YH
• Park YH

• KMID: 2534192
• DOI: http://doi.org/10.4143/crt.2021.1103

Abstract

Purpose
Trastuzumab has markedly improved the survival outcomes of patients with human epidermal growth factor receptor 2 (HER2)–positive breast cancer, and dual blockade of HER2 using trastuzumab and pertuzumab in combination with taxanes (THP) has become a standard of care for HER2-positive metastatic breast cancer (MBC) worldwide since the CLEOPATRA trial. We assessed the outcomes of THP as a first-line treatment for Korean HER2-positive MBC patients in the real-world setting.
Materials and Methods
Between August 2008 and October 2020, we identified 228 HER2-positive MBC patients who received THP as a first-line palliative chemotherapy. We analyzed survival outcomes, efficacy, and adverse events of THP retrospectively.
Results
After a median follow-up duration of 28.7 months, median overall survival and progression-free survival were 58.3 months (95% confidence interval [CI], 36.6 to 80.0) and 19.1 months (95% CI, 16.2 to 21.9), respectively. Better survival outcomes were observed in patient who received docetaxel for more than six cycles. Patients exposed to anti-HER2 directed therapies in a perioperative setting had poor survival outcomes. The overall response rate was 86.8% with a complete response (CR) rate of 17.7%. Among responders, 16.7% of patients sustained THP over 35 months and showed better survivals and higher CR rates. Adverse events were comparable to those reported in previous studies.
Conclusion
In a real-world context, clinical outcomes of Korean HER2-positive MBC patients treated with THP were similar to those of patients in the CLEOPATRA trial. Much longer follow-up results would be warranted.

Keyword

Metastatic breast cancer; HER2 positive; Trastuzumab; Pertuzumab; Docetaxel

Figure

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  Fig. 1 OS (A) and PFS (B) after THP treatment. OS according to the number of docetaxel administrations (C) and exposure to trastuzumab prior to THP treatment (D). CI, confidence interval; OS, overall survival; PFS, progression-free survival; THP, docetaxel, trastuzumab, pertuzumab.

• 

  Fig. 2 Overall survival according to long-term responses (A). Comparison of response rates (B) and trastuzumab exposure (C) between long-term responders and non–long-term responders.

Reference

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