Clin Psychopharmacol Neurosci.
2022 Aug;20(3):462-473. 10.9758/cpn.2022.20.3.462.
Methylome-wide Association Study of Patients with Recent-onset Psychosis
- Affiliations
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- 1Department of Psychiatry, Jeonbuk National University Medical School, Jeonju, Korea
- 2Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea
- 3Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
- 4Department of Social Psychiatry and Rehabilitation, National Center for Mental Health, Seoul, Korea
- 5Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea
- 6Department of Psychiatry, The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul, Korea
- 7Department of Psychiatry, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
- KMID: 2532808
- DOI: http://doi.org/10.9758/cpn.2022.20.3.462
Abstract
Objective
Dysregulation of gene expression through epigenetic mechanisms may have a vital role in the pathogenesis of schizophrenia (SZ). In this study, we investigated the association of altered methylation patterns with SZ symptoms and early trauma in patients and healthy controls.
Methods
The present study was conducted to identify methylation changes in CpG sites in peripheral blood associated with recent-onset (RO) psychosis using methylome-wide analysis. Lifestyle factors, such as smoking, alcohol, exercise, and diet, were controlled.
Results
We identified 2,912 differentially methylated CpG sites in patients with RO psychosis compared to controls. Most of the genes associated with the top 20 differentially methylated sites had not been reported in previous methylation studies and were involved in apoptosis, autophagy, axonal growth, neuroinflammation, protein folding, etc. The top 15 significantly enriched Kyoto Encyclopedia of Genes and Genomes pathways included the oxytocin signaling pathway, long-term depression pathway, axon guidance, endometrial cancer, long-term potentiation, mitogen-activated protein kinase signaling pathway, and glutamatergic pathway, among others. In the patient group, significant associations of novel methylated genes with early trauma and psychopathology were observed.
Conclusion
Our results suggest an association of differential DNA methylation with the pathophysiology of psychosis and early trauma. Blood DNA methylation signatures show promise as biomarkers of future psychosis.
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