Clin Psychopharmacol Neurosci.  2024 May;22(2):387-389. 10.9758/cpn.23.1103.

Mirtazapine Monotherapy for Antipsychotics-refractory Psychosis in a Patient with Very-late-onset Schizophrenia-like Psychosis: A Case Report

Affiliations
  • 1Department of Neuropsychiatry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
  • 2Department of Psychiatry, Jinkei Hospital, Himeji, Japan
  • 3Department of Psychiatry, Takatsuki Hospital, Hachiouji, Japan

Abstract

Very-late-onset schizophrenia-like psychosis (VLOSLP) is a condition in which psychotic symptoms emerge after the age of 60 years. Given its heterogeneous nature, VLOSLP remains a diagnostic and therapeutic dilemma. Here, we report a case of a 68-year-old patient with psychosis refractory to antipsychotics who was successfully treated with mirtazapine monotherapy. This case suggests that mirtazapine monotherapy may be effective for the treatment of patients with antipsychotic-refractory VLOSLP.

Keyword

Mirtazapine; Antipsychotics-refractory psychosis; Late-onset schizophrenia
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