- Risperidone Induced DNA Methylation Changes in Dopamine Receptor and Stathmin Genes in Mice Exposed to Social Defeat Stress
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Rami FZ, Nguyen TB, Oh YE, Karamikheirabad M, Le TH, Chung YC
- KMID: 2530472
- Clin Psychopharmacol Neurosci.
- 2022 May;20(2):373-388.
- doi: 10.9758/cpn.2022.20.2.373
Objective: Understanding complex epigenetic mechanisms is necessary to fully elucidate the effects of antipsychotic drug. This study investigated DNA methylation and mRNA expression levels of dopamine D2 and D1 receptor... -
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- Impact of Social Defeat Stress on DNA Methylation in Drd2, Nr3c1, and Stmn1 in Wild-type and Stmn1 Knock-out Mice
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Oh YE, Nguyen TB, Rami FZ, Karamikheirabad M, Chung YC
- KMID: 2526847
- Clin Psychopharmacol Neurosci.
- 2022 Feb;20(1):51-60.
- doi: 10.9758/cpn.2022.20.1.51
Objective: Epigenetic profiles can be modified by stress. Dopamine receptor D2 (Drd2), glucocorticoid receptor gene (Nr3c1) and Stathmin 1 (Stmn1) genes are all implicated in adaptation to stress. The aim... -
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- Methylome-wide Association Study of Patients with Recent-onset Psychosis
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Piao YH, Cui Y, Rami FZ, Li L, Karamikheirabad M, Kang SH, Kim SW, Kim JJ, Lee BJ, Chung YC
- KMID: 2532808
- Clin Psychopharmacol Neurosci.
- 2022 Aug;20(3):462-473.
- doi: 10.9758/cpn.2022.20.3.462
Objective: Dysregulation of gene expression through epigenetic mechanisms may have a vital role in the pathogenesis of schizophrenia (SZ). In this study, we investigated the association of altered methylation patterns... -
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- Development of the Korea-Polyenvironmental Risk Score for Psychosis
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Jeon EJ, Kang SH, Piao YH, Kim SW, Kim JJ, Lee BJ, Yu JC, Lee KY, Won SH, Lee SH, Kim SH, Kim ET, Kim CT, Oliver D, Fusar-Poli P, Rami FZ, Chung YC
- KMID: 2527415
- Psychiatry Investig.
- 2022 Mar;19(3):197-206.
- doi: 10.30773/pi.2021.0328
Objective Comprehensive understanding of polyenvironmental risk factors for the development of psychosis is important. Based on a review of related evidence, we developed the Korea Polyenvironmental Risk Score (K-PERS) for... -
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