Psychiatry Investig.
2022 Mar;19(3):197-206. 10.30773/pi.2021.0328.
Development of the Korea-Polyenvironmental Risk Score for Psychosis
- Jeon EJ
1 - Kang SH2
- Piao YH3
- Kim SW4
- Kim JJ5
- Lee BJ6
- Yu JC7
- Lee KY8
- Won SH9
- Lee SH10
- Kim SH11
- Kim ET12
- Kim CT13
- Oliver D14,15
- Fusar-Poli P14,15,16
- Rami FZ3
- Chung YC1,3,17
- Affiliations
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- 1Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Republic of Korea
- 2Department of Social Psychiatry and Rehabilitation, National Center for Mental Health, Seoul, Republic of Korea
- 3Department of Psychiatry, Jeonbuk National University Medical School, Jeonju, Republic of Korea
- 4Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea
- 5Department of Psychiatry, The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul, Republic of Korea
- 6Department of Psychiatry, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea
- 7Department of Psychiatry, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Republic of Korea
- 8Department of Psychiatry, Nowon Eulji Medical Center, Eulji University, Seoul, Republic of Korea
- 9Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
- 10Department of Psychiatry, Inje University Ilsan Paik Hospital, Goyang, Republic of Korea
- 11Department of Psychiatry, Korea University College of Medicine, Guro Hospital, Seoul, Republic of Korea
- 12Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
- 13Institute of Life and Death Studies, Hallym University, Chuncheon, Republic of Korea
- 14Early Psychosis: Interventions and Clinical Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
- 15OASIS Service, South London and the Maudsley NHS Foundation Trust, London, United Kingdom
- 16Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy
- 17Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea
- KMID: 2527415
- DOI: http://doi.org/10.30773/pi.2021.0328
Abstract
Objective
Comprehensive understanding of polyenvironmental risk factors for the development of psychosis is important. Based on a review of related evidence, we developed the Korea Polyenvironmental Risk Score (K-PERS) for psychosis. We investigated whether the K-PERS can differentiate patients with schizophrenia spectrum disorders (SSDs) from healthy controls (HCs).
Methods
We reviewed existing tools for measuring polyenvironmental risk factors for psychosis, including the Maudsley Environmental Risk Score (ERS), polyenviromic risk score (PERS), and Psychosis Polyrisk Score (PPS). Using odds ratios and relative risks for Western studies and the “population proportion” (PP) of risk factors for Korean data, we developed the K-PERS, and compared the scores thereon between patients with SSDs and HCs. In addition, correlation was performed between the K-PERS and Positive and Negative Syndrome Scale (PANSS).
Results
We first constructed the “K-PERS-I,” comprising five factors based on the PPS, and then the “K-PERS-II” comprising six factors based on the ERS. The instruments accurately predicted participants’ status (case vs. control). In addition, the K-PERS-I and -II scores exhibited significant negative correlations with the negative symptom factor score of the PANSS.
Conclusion
The K-PERS is the first comprehensive tool developed based on PP data obtained from Korean studies that measures polyenvironmental risk factors for psychosis. Using pilot data, the K-PERS predicted patient status (SSD vs. HC). Further research is warranted to examine the relationship of K-PERS scores with clinical outcomes of psychosis and schizophrenia.
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