Clin Psychopharmacol Neurosci.  2017 Feb;15(1):68-69. 10.9758/cpn.2017.15.1.68.

Disulfiram Induced Psychosis

• Mohapatra
• Rath NR

• KMID: 2367666
• DOI: http://doi.org/10.9758/cpn.2017.15.1.68

Abstract

Disulfiram is the commonly prescribed drug for the treatment of alcohol dependence. It's major metabolite (diethyldithiocarbamate) is an inhibitor of dopamine-betahydroxylase, an enzyme that catalyzes the metabolism of dopamine to norepinephrine resulting in psychosis. We recommend that disulfiram should be used at the lowest effective dose, possibly 250 mg daily and caution should be taken while prescribing disulfiram for patients with personal and familial antecedents of psychosis.

Keyword

Disulfiram; Psychosis; Side effect

MeSH Terms

Alcoholism
Disulfiram*
Dopamine
Humans
Metabolism
Norepinephrine
Psychotic Disorders*
Disulfiram
Dopamine
Norepinephrine