J Korean Neurol Assoc.  2022 May;40(2):164-167. 10.17340/jkna.2022.2.11.

An Autopsy Confirmed Case of Amyotrophic Lateral Sclerosis with TDP Pathology

Affiliations
  • 1Department of Neurology and Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea
  • 2Department of Rehabilitation Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea
  • 3Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
  • 4Department of Neurology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea
  • 5Department of Psychiatry , Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea
  • 6Department of Rehabilitation Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea
  • 7Department of Nuclear Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea
  • 8Department of Neurosurgery, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea
  • 9Department of Pathology, Pusan National University School of Medicine, Busan, Korea
  • 10Department of Anatomy, Pusan National University School of Medicine, Busan, Korea
  • 11Department of Forensic Medicine, Pusan National University School of Medicine, Busan, Korea

Abstract

The phosphorylated 43-kDa transactive response DNA-binding protein (TDP-43) was identified as a major disease protein in sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. We present a case with progressive muscle weakness who was diagnosed with sporadic ALS. On postmortem examination, TDP-43 immunoreactive neuronal cytoplasmic inclusions were noted in motor cortex, hippocampus and anterior horns of spinal cord, which was compatible with ALS-TDP, stage 4. This is the first documented autopsy-confirmed ALS case with ALS-TDP pathology in Korea.

Keyword

Amyotrophic lateral sclerosis; TDP; Autopsy
Full Text Links
  • JKNA
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr