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Melatonin modulates nitric oxide-regulated WNK-SPAK/OSR1-NKCC1 signaling in dorsal raphe nucleus of rats

Yang HJ, Kim MJ, Kim SS, Cho YW

The sleep-wake cycle is regulated by the alternating activity of sleep- and wake-promoting neurons. The dorsal raphe nucleus (DRN) secretes 5-hydroxytryptamine (5-HT, serotonin), promoting wakefulness. Melatonin secreted from the pineal...
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Latent Tuberculosis Infection Screening and Treatment in Congregate Settings (TB FREE COREA): Demographic Profiles of InterferonGamma Release Assay Cohort

Kim HW, Min J, Choi JY, Shin AY, Myong JP, Lee Y, Yim HW, Jeong H, Bae S, Shim E, In H, Chun C, Kim G, Kang JY, Lee SS, Park JS, Kim JS

In 2017, the Korean government launched an unprecedentedly large-scaled latent tuberculosis infection (LTBI) screening project which covered more than a million individuals in congregate settings. A total of 1,047,689 participants...
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Altered Gene Expression Profiles in Neural Stem Cells Derived from Duchenne Muscular Dystrophy Patients with Intellectual Disability

Koo J, Park S, Sung SE, Lee J, Kim DS, Lee J, Lee JR, Kim NS, Lee DY

  • KMID: 2519888
  • Exp Neurobiol.
  • 2021 Aug;30(4):263-274.
  • doi: 10.5607/en21008
Intellectual disability (ID) is a neurodevelopmental disorder defined by below-average intelligence (intelligence quotient of
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A Study on the Relationship Between Mental Health Variables and Physical Activity Variables in the Clinical Group of North Korean Defectors: A Pilot Study

Shim SS, Lee SH, Lee JB, Seo YE, Lee HJ

Objectives This study is designed to extract a representative variable that distinguishes psychiatric patients of North Korean Defectors and a control group by using machine learning based on measured mental...
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Treatment of Ankylosing Spondylitis

Kang BJ, Jo SS, Park YS

Ankylosing spondylitis causes ankylosis of the spine due to ossification of the articular cartilage and ligaments around the vertebral body as well as the sacroiliac joint. This pathophysiology limits joint...
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Diverting ileostomy itself may not increase the rate of postoperative readmission related to dehydration after low anterior resection

Park SS, Kim MJ, Lee DE, Park SC, Han KS, Hong CW, Sohn DK, Chang HJ, Oh JH

Purpose: This study was performed to evaluate the risk of readmission in the first year after low anterior resection (LAR) for patients with rectal cancer and to identify the contributing...
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Patient Perspectives and Preferences Regarding Gout and Gout Management: Impact on Adherence

Chung MK, Kim SS, Cheon YH, Hong SJ, Choi HJ, Seo MR, Hwang J, Ahn JK, Lee SH, Min HK, Cha HS, Lee SS, Lee J, Moon KW, Lee CK, Kim HO, Suh YS, Shim SC, Kang SW, Kim J, Choi ST, Song JS, Lee J, Korean Society of Gout Research

Background: Patient-centered management is becoming increasingly important in gout, but there are limited studies exploring patients' perspectives and preferences. We aimed to investigate patients' perspectives and preferences regarding gout and...
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Bath Ankylosing Spondylitis Disease Activity Index is Associated With the Quality of Sleep in Ankylosing Spondylitis Patients

Song BW, Jeong HJ, Kim BY, Cho YW, Son CN, Kim SS, Kim SH

Objective High disease activity of ankylosing spondylitis (AS) is associated with poor sleep quality. The purpose of this study was to identify which of the representative tools for evaluating the...
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Fimasartan-Based Blood Pressure Control after Acute Cerebral Ischemia: The Fimasartan-Based Blood Pressure Control after Acute Cerebral Ischemia Study

Hong KS, Kwon SU, Park JH, Cha JK, Jung JM, Kim YJ, Lee KB, Sohn SI, Lee YS, Rha JH, Kwon JH, Han SW, Kim BJ, Koo J, Choi JC, Sung SM, Lee SJ, Park MS, Ahn SH, Bang OY, Hwang YH, Nam HS, Park JM, Bae HJ, Kim EG, Lee KY, Oh MS

Background and Purpose: Blood pressure (BP) control is strongly recommended, but BP control rate has not been well studied in patients with stroke. We evaluated the BP control rate with...
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Accuracy and Performance Evaluation of Triplet Repeat Primed PCR as an Alternative to Conventional Diagnostic Methods for Fragile X Syndrome

Gu H, Kim MJ, Yang D, Song JY, Cho SI, Park SS, Seong MW

Background: Conventional diagnosis of fragile X syndrome (FXS) is based on a combination of fragment analysis (FA) and Southern blotting (SB); however, this diagnostic approach is time- and labor-intensive and...
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Comparison of patient-reported quality of life and functional outcomes following laparoscopic and transanal total mesorectal excision of rectal cancer

Ha RK, Park SC, Park B, Park SS, Sohn DK, Chang HJ, Oh JH

Purpose: The effect of transanal total mesorectal excision (TaTME) on patients’ quality of life and functional outcomes is not fully understood. This study aimed to compare the quality of life...
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Inhibitory effect of mangosteen peel and propolis ethanol extracts on alveolar bone loss against increased treatment amount of Porphyromonas gingivalis lipopolysaccharide in rat

Lee KH, Yoo SY, Kook JK, Sung SJ, Lee KW, Lim YK, Lee DS, Yu SJ

In previous studies, we introduced that mangosteen extract complex (MEC; ethanol extracts of Garcinia mangostana L. peel and propolis) had inhibitory effects on inflammation and alveolar bone loss in silk-ligature...
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Cell Type-specific Knockout with Gli1-mediated Cre Recombination in the Developing Cerebellum

Choi JM, Acharya R, Marasini S, Narayan B, Lee KW, Hwang WS, Chang DY, Kim SS, Kim HS

  • KMID: 2517473
  • Exp Neurobiol.
  • 2021 Jun;30(3):203-212.
  • doi: 10.5607/en21017
The inducible Cre-loxP system provides a useful tool for inducing the selective deletion of genes that are essential for proper development and enables the study of gene functions in properly...
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Laparoscopic hepatobiliary and pancreatic surgery:my trials and current status in Korea

Yun SS

There has been a dramatic change in surgical care over the past 30 years with the introduction of laparoscopic surgery. It was my great fortune that I could experience laparoscopic...
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The Efficacy of Mycophenolate Mofetil in Remission Maintenance Therapy for Microscopic Polyangiitis and Granulomatosis with Polyangiitis

Pyo JY, Lee LE, Ahn SS, Song JJ, Park YB, Lee SW

Purpose: The present study compared the efficacy of mycophenolate mofetil (MMF) with that of azathioprine (AZA) in Korean patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). Materials and Methods:...
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Pre-transplant Dementia is Associated with Poor Survival After Hematopoietic Stem Cell Transplantation: A Nationwide Cohort Study with Propensity Score Matched Control

Wang SM, Park SS, Park SH, Kim NY, Kang DW, Na HR, Bae YY, Lee JW, Han S, Lim HK

Objective: No previous study examined impact of dementia in the outcome of allogeneic hematopoietic stem cell transplantation (HSCT). We aimed to investigate overall survival (OS) of patients with dementia after...
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Projected lifetime cancer risk from cone-beam computed tomography for orthodontic treatment

Jha N, Kim YJ, Lee Y, Lee JY, Lee WJ, Sung SJ

Objective: To estimate the projected cancer risk attributable to diagnostic cone-beam computed tomography (CBCT) performed under different exposure settings for orthodontic purposes in children and adults. Methods: We collected a...
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Impact of Bisoprolol on Ventricular Arrhythmias in Experimental Myocardial Infarction

Kim HK, Lim KS, Kim SS, Na JY

Following acute myocardial infarction (AMI), early use of beta-blockers (BBs) reduced the incidences of ventricular arrhythmia (VA) and death in the pre reperfusion era. However, some studies have reported a worsening...
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Male Sex Is a Significant Predictor of All-cause Mortality in Patients with Antineutrophil Cytoplasmic Antibodyassociated Vasculitis

Kwon HC, Pyo JY, Lee LE, Ahn SS, Song JJ, Park YB, Lee SW

Background: We investigated and compared the initial clinical features at diagnosis and the poor outcomes during follow-up in Korean patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) based on sex. Methods:...
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Effect of phosphodiesterase type 5 inhibitors on sperm motility and acrosome reaction: An in vitro study

Song SH, Shin DH, Her YS, Oh MH, Baek JW, Sung S, Eum JH, Heo Y, Kim DS

Purpose: Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the...
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