J Korean Neurol Assoc.
2015 Aug;33(3):178-182. 10.17340/jkna.2015.3.7.
An Autopsy Confirmed Case of Behavioral Variant Frontotemporal Dementia with Corticobasal Degeneration Pathology
- Affiliations
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- 1Department of Neurology, Pusan National University School of Medicine, Yangsan, Korea.
- 2Department of Pathology, Pusan National University School of Medicine, Yangsan, Korea.
- 3Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea.
- 4Department of Nuclear Medicine, Pusan National University School of Medicine, Yangsan, Korea.
- 5Department of Rehabilitation Medicine, Pusan National University School of Medicine, Yangsan, Korea.
- 6Department of Anatomy, Pusan National University School of Medicine, Yangsan, Korea.
- 7Department of Forensic Medicine, Pusan National University School of Medicine, Yangsan, Korea. gyhuh@pusan.ac.kr
- 8Memory and Aging Center, University of California San Francisco, CA, USA.
- KMID: 2184595
- DOI: http://doi.org/10.17340/jkna.2015.3.7
Abstract
- A 63-year-old man presented with a 1.5-year history of progressive personality changes. Clinical evaluations revealed severe frontal dysfunction and bilateral frontal atrophy/glucose hypometabolism. He was diagnosed as probable behavioral variant frontotemporal dementia. He continued to decline, and died at the age of 66. At autopsy, numerous tau-positive gilial threads and coiled bodies were observed in the white matter. Tau-positive astrocytic plaques and neuronal cytoplasmic inclusions were also seen in cerebral cortices, which were compatible with corticobasal degeneration.
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